ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2018 American Transplant Congress

    Kidney Transplant Outcomes in Patients with CPRA Values > 98% after Implementation of the New OPTN/UNOS Kidney Allocation System (KAS): A Single Center Study Update

    N. Kaur,1 M. Kamoun,2 J. Kearns,2 J. Trofe-Clark,1 P. Abt,3 M. Levine,3 S. Goral.1

    1Department of Medicine, Renal-Electrolyte and Hypertension Division, Hospital of the University of Pennsylvania, Philadelphia; 2Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia; 3Surgery, Hospital of the University of Pennsylvania, Philadelphia.

    Background: Sensitized patients in the past have had prolonged waiting times and greater incidence of death while on the waiting list. On December 4, 2014,…
  • 2018 American Transplant Congress

    Absence of Rejection in a Facial Allograft Recipient with a Postive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20+ Monoclonal Antibody

    B. Gelb,1 J. Diaz-Siso,2 N. Plana,2 A. Jacoby,2 W. Rifkin,2 K. Khouri,2 D. Ceradini,2 E. Rodriguez.2

    1Transplant Institute, NYU Langone Health, New York, NY; 2Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY.

    OBJECTIVE: Vascularized composite allograft (VCA) transplantation has become a feasible reconstructive option for patients with severe facial disfigurement. Short term patient and graft survival have…
  • 2018 American Transplant Congress

    Renal Allograft Cortical Perfusion Quantification by 3D-Arterial Spin Labeling Could Be Used to Identify Subclinical Antibody-Mediated Rejection

    W. Wang,1 J. Wen,2 F. Xu,2 Y. Yu,3 L. Zhang,3 Z. Liu.2

    1Nanjing Medical University, Jinling School of Medicine, Nanjing, China; 2Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, China; 3Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

    Background: Antibody-mediated rejection (AMR) is now the most principal post-surgical complication complicating allograft long-term survival. Therefore, its early detection before serum creatinine rises/estimated glomerular filtration…
  • 2018 American Transplant Congress

    Modification of Macrophage Phenotype by the Magnetic Field

    M. Kloc,1 W. Chen,1 J. Kubiak,2,3 X. Li,1 R. Ghobrial,1 J. Wosik.4

    1Houston Methodist Research Institute, Houston, TX; 2WIHE, Warsaw, Poland; 3University of Rennes, Rennes, France; 4University of Houston, Houston.

    Objective. Macrophages play a crucial role in health, disease and chronic rejection of transplanted organs. Chronic rejection of transplanted organs remains unresolved issue in organ…
  • 2018 American Transplant Congress

    Delayed Achievement of Therapeutic Tacrolimus Levels after Renal Transplantation is Not Associated with Increased Incidence of Early Acute Rejection: Single-Center Results

    R. Marshall, J. Brandenberger, A. Cantafio, J. Halldorson, R. Bakthavatsalam, A. Dick, S. Rayhill, J. Reyes, J. Perkins.

    Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA.

    Induction therapy followed by maintenance with a calcineurin inhibitor aims to minimize the incidence of early rejection and optimize the potential for allograft function. However…
  • 2018 American Transplant Congress

    The Protective Effect of Multivisceral Transplantation on Intestinal Allograft Rejection – Its Correlation with T-Cell Macrochimerism from a Long-Term Prospective Study

    P. Liou,1 M. Martinez,1 J. Fu,2 M. Velasco,1 A. Griesemer,1 S. Lobritto,1 J. Vittorio,1 S. Ravella,1 B. Levin,3 J. Emond,1 M. Sykes,2 T. Kato.1

    1Center for Liver Disease and Transplantation, Columbia University, New York, NY; 2Columbia Center for Translational Immunology, Columbia University, New York, NY; 3Department of Biostatistics, Columbia University, New York, NY.

    Objective Graft rejection remains the crux of intestinal transplantation. Although liver-inclusive grafts appear to be protective, the mechanism remains unknown. We hypothesize that T-cell macrochimerism…
  • 2018 American Transplant Congress

    Inflammation in Scarred Areas (I-IFTA) is a Reflection of Parenchymal Injury (Response to Wounding) Not T Cell-Mediated Rejection

    P. Halloran, J. Chang, K. Famulski.

    Medicine, University of Alberta, Edmonton, AB, Canada.

    Inflammation in fibrotic renal parenchyma (i-IFTA) is associated with decreased graft survival but by Banff rules is not diagnostic for rejection. Some researchers believe that…
  • 2018 American Transplant Congress

    Donor Reactive Eomesderminhi CD8+ T Cells Are Significantly Upregulated Early after Transplant in Kidney Transplant Patients without Rejection

    A. Perez-Gutierrez,1,2 D. Metes,1 S. Hariharan,1 A. Thomson,1 M. Ezzelarab.1

    1Surgery, Thomas Starzl Transplantation Institute, Pittsburgh, PA; 2Surgery, Transplantation Institute, University of Chicago, Chicago, IL.

    IntroductionMemory T cell responses play a critical role in the outcome of allo-transplantation. While the role of the T-box transcription factor Eomesodermin (Eomes) in the…
  • 2018 American Transplant Congress

    Prospective Multicenter Validation of Human Transitional B Cell Cytokines as a Predictive Biomarker in Renal Transplantation

    A. Cherukuri,1 D. Chittka,1 A. Sharma,1 A. Salama,2 C. Magee,2 D. Rothstein.1

    1UPMC, Pittsburgh; 2UCL, London, United Kingdom.

    In renal transplantation, non-invasive biomarkers are needed to identify patients at risk for poor outcomes and guide pre-emptive therapy. Here, we assessed B cell cytokines…
  • 2018 American Transplant Congress

    Intragraft MicroRNA Transcriptome of Acute Antibody Mediated Rejection of Human Kidney Allografts

    H. Yang,1 K. Akat,2 C. Li,1 C. Snopkowski,1 Z. Khan,1 D. Dadhania,1 T. Tuschl,2 M. Suthanthiran,1 T. Muthukumar.1

    1Weill Cornell Medicine, New York; 2Rockefeller University, New York.

    BackgroundMicroRNAs (miRNA) are master regulators of gene expression and are potential therapeutic targets. Intragraft miRNA transcriptome of acute antibody rejection (AMR) of human kidney allograft…
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