2018 American Transplant Congress
Two Similar Risk Models Identify Different Patients for Graft Loss: Implications for Clinical Trials in DSA+ Kidney Transplant Recipients
William J von Liebig Transplant Center, Mayo Clinic, Rochester.
Introduction. Kidney Transplant Recipients (KTx) with donor-specific alloantibody (DSA) at transplantation have increased death-censored graft failure (DCGF) due to chronic antibody mediated rejection (cABMR), but…2018 American Transplant Congress
A “Multi-Omic” Analysis of Proteome and Metabolome for Acute Rejection and PVAN in Kidney Transplantation
Background: Most effort in identifying biomarkers have used gene expression analyses. Proteomics and metabolomics are useful to identify surrogate biomarkers in monitoring transplanted kidney and…2018 American Transplant Congress
Impact of Direct Antiviral Therapy for Hepatitis C on Acute Rejection and DSA Formation in Kidney Transplant Recipients
Cleveland Clinic, Cleveland, OH.
Background: Hepatitis C virus infection (HCV) has historically portended a poor outcome after kidney transplantation. With recent advent of direct antiviral agents (DAA), there has…2018 American Transplant Congress
Bone Marrow Derived Myeloid Suppressor Cell (BM-MDSCs) Prolongs the Graft Survival in Murine Heart Transplantation
Atopy(Allergy) Research Center, Juntento University, Tokyo, Japan.
Purpose: To investigate the impact of BM-MDSCs on murine heart transplantationMaterial and Methods:Bone marrow cells were harvested and cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and…2018 American Transplant Congress
Five-Year Outcomes after Randomized Treatment by Rituximab in Early Acute Antibody-Mediated Rejection in Renal Transplantation: Long Term Outcomes of the RITUX ERAH Study
Background The place of rituximab in the treatment of acute antibody-mediated rejection (ABMR) is still controversial. The French multicenter double-blind, placebo-controlled RITUX ERAH study included…2018 American Transplant Congress
Impact of Infections on Patients with Left Ventricle Assist Devices(LVAD): Allo-Sensitization and Heart Transplantation
Virginia Commonwealth University, Richmond.
Background: The impact of post-LVAD infections on allosensitization and heart transplantation (HT) is unknown. High levels of panel reactive antibodies (PRA) preclude HT but the…2018 American Transplant Congress
Inhibition of IL-1R1 Signaling Delays Costimulation Blockade–Resistant Allograft Rejection by Preventing CD8 TEM Expansion
Department of Surgery, Emory University, Atlanta, GA.
The clinical utilization of Costimulaiton Blockade (CoB) led to improved long-term patient outcomes, but wider adoption of is hampered by increased rates of acute cellular…2018 American Transplant Congress
Early Microcirculation Inflammation Associated with TCMR Leads to Poor Graft Outcomes in Kidney Transplant Recipients (KTRs)
Renal allograft microcirculation inflammation (MI) lesions including glomerulitis (g) and peritubular capillaritis (ptc) are associated with AMR and poor outcomes. The significance of MI lesions…2018 American Transplant Congress
Interim Results of the kSORT in the SAILOR Randomized Multicenter Trial
1Sahlgrenska University Hospital, Göteborg, Sweden; 2UCSF, San Francisco.
Background: In a randomized multicenter trial of 222 renal tx recipients treated with steroid minimization and a tacrolimus, MMF based regimen, a novel gene expression…2018 American Transplant Congress
Protocolar Biopsies in Patients with Subclinical De Novo DSA in Kidney Transplantation
De novo donor-specific antibody (DSA) is associated with antibody-mediated rejection (ABMR) and allograft loss. The aim of our study was to examine the histology associated…
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