Articles tagged "Rejection"

2018 American Transplant Congress
Class II Anti-HLA IgG2 and IgG3 DSAs Predict Poorer Outcomes in Chronic Antibody Mediated Rejection of Renal Allografts
A. Gueret-Wardle,¹ G. Lucisano,¹ S. Hassan,¹ P. Brookes,² E. Santos-Nunez,² D. Goodall,¹ C. Clarke,¹ J. Galliford,¹ M. Willicombe,¹ D. Taube.¹
¹Renal and Transplant Centre, Imperial College London NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics, Imperial College London, London, United Kingdom.
Introduction: whilst the development of IgG3 and C1q binding de novo [dn] HLA DSAs are associated with a poor outcome in acute antibody mediated rejection,…
2018 American Transplant Congress
A Follow-Up Report on the Use of IVIG+Rituximab to Reduce Donor Specific Antibodies and Improve Transplant Rates in Highly-Sensitized Patients Awaiting Deceased Donor Kidney Transplantation
R. Najjar, E. Huang, A. Vo, J. Choi, K. Lim, S. Louie, A. Peng, S. Sethi, M. Toyoda, X. Zhang, S. Jordan.
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction: Desensitization (DES) with IVIG/rituximab is associated with a reduction in donor specific antibodies (DSA), improved transplant rates and outcomes in highly-sensitized (HS) patients. We…
2018 American Transplant Congress
Recipient IFNAR1 Signaling Supports Costimulation Independent Rejection by Promoting T Cell Activation
D. Mathews, A. Ghosh, Y. Dong, K. Polireddy, A. Stephenson, C. Breeden, Y. Liu, A. Adams.
Department of Surgery, Emory University, Atlanta, GA.
Costimulation blockade (CoB) is a promising strategy for more targeted/less toxic transplant immunosuppression which has led to the first improvement in long-term outcomes for transplant…
2018 American Transplant Congress
Association of Leptin with Cystatin C in Kidney Allograft Dysfunction
A. Bera,¹ M. Watson,² N. Gana,¹ J. Karaian,¹ S. Radhakrishnan,¹ M. Subramanian,¹ D. Little,² R. Nee,² A. Chatterjee,¹ S. Rothwell,¹ H. Pollard,¹ R. Jindal,³ M. Srivastava.¹
¹Anatomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD; ²Nephrology, USU-Walter Reed, Bethesda, MD; ³Surgery, USU-Walter Reed, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring recipients of kidney allografts to predict acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft…
2018 American Transplant Congress
Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant
A. Brubaker,¹ D. Stoltz,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹
¹Department of Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; ²CareDx, Brisbane, CA.
Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…
2018 American Transplant Congress
Clinical Heterogeneity of Early Anamnestic Donor Specific Antibody Responses in Kidney Transplantation
A. Loethen,¹ A. Lichvar,¹ S. Tremblay,¹ A. Shields,^1,2 A. Dao,¹ M. Cardi,² P. Brailey,¹ A. Girnita,¹ B. Abu Jawdeh,¹ R. Alloway,¹ E. Woodle.¹
¹U of Cincinnati, Cincinnati, OH; ²Christ Hospital, Cincinnati, OH.
Anamnestic donor specific antibody(DSA) responses in the early post-transplant period may threaten the renal transplant(RTx). We hypothesize earlier DSA detection will allow minimization of RTx…
2018 American Transplant Congress
High Fibre Diet Induces Donor Specific Kidney Allograft Tolerance in Mice
H. Wu,^1,2 T. Kwan,² Y. Loh,² C. Wang,² L. Macia,² S. Alexander,^2,3 S. Chadban.^1,2
¹Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³The Children Hospital at Westmead, Sydney, Australia.
Aim: To investigate the impact of high fibre (HF) diet or dietary supplementation with the short chain fatty acid sodium acetate (SA) on kidney allograft…
2018 American Transplant Congress
Air Pollution Can Support the Development of Cardiac Allograft Vasculopathy
C. Bara,¹ M. Barten,² D. Boethig,¹ Y. Scheibner,¹ J. Tauber,² H. Reichenspurner,² A. Haverich.¹
¹Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Cardiovascular Surgery, University Heart Center, Hamburg, Germany.
Purpose:Cardiac allograft vasculopathy (CAV) remains one of most important factors leading to graft dysfunction and mortality after heart transplantation (HTx). Thus, the identification of risk…
2018 American Transplant Congress
Analysis of Cost Effectiveness of Treatment for Acute Antibody-Mediated Rejection
C. McDermott, K. Carsky, P. Ferrin, A. Gaines, D. Chernobylsky, M. Killackey, A. Paramesh, R. Zhang, J. Buell.
Tulane University School of Medicine, New Orleans, LA.
Purpose: Because AMR can be a risk factor for graft loss, the expense created by AMR treatment may be subject to scrutiny in patients who…
2018 American Transplant Congress
Failure to Remove De Novo Donor-Specific HLA Antibodies is Influenced by Antibody Properties and Identifies Kidney Recipients with Late Antibody-Mediated Rejection Destined to Graft Loss
A. Nocera,¹ M. Cioni,¹ A. Tagliamacco,² S. Basso,³ A. Innocente,⁴ I. Fontana,⁵ A. Magnasco,¹ A. Trivelli,¹ A. Gurrado,³ M. Ramondetta,⁴ S. Boghen,³ L. Catenacci,³ E. Verrina,¹ G. Garibotto,² G. Ghiggeri,¹ M. Cardillo,⁴ F. Ginevri,¹ P. Comoli.³
¹Pediatric Nephrology Unit, IRCCS G. Gaslini, Genova, Italy; ²Clinical Nephrology Unit, University of Genova, Genova, Italy; ³Transplant Immunology and Pediatric Hematology/Oncology, IRCCS Policlinico S. Matteo, Pavia, Italy; ⁴Transplantation Immunology, Ospedale Maggiore Policlinico, Milano, Italy; ⁵Kidney Transplant Surgery Unit, Ospedale Policlinico San Martino, Genova, Italy.
Late antibody-mediated rejection (AMR) is the major cause of renal allograft loss. Current research is focusing on identifying a performant risk stratification in order to…