Articles tagged "Rejection"

2018 American Transplant Congress
Molecular Monitoring for Kidney Allograft Injury Following HLA Incompatible Transplantation
A. Jackson,¹ B. Iglehart,¹ S. Bagnasco,³ N. Desai.²
¹Medicine, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD; ³Pathology, Johns Hopkins University, Baltimore, MD.
Elevated donor derived cell free DNA (ddcfDNA) has been shown to correlate with allograft rejection following heart, lung, and kidney transplantation. We investigated whether sequential…
2018 American Transplant Congress
Temporal Variability of IgG Subclasses
D. Pinelli, M. Gopalakrishnan, A. Joong, P. Thrush, A. Tambur.
Northwestern University, Chicago; Lurie Children's Hospital, Chicago.
The temporal model of IgG subclass switching supports sequential IgG conversion; however, the diversity of previously stimulated B cells is known to shape responses in…
2018 American Transplant Congress
Genome-Wide Association Study Assessing Risk of Rejection in Pediatric Transplant Recipients
T. Papaz,¹ S. Min,¹ O. Lee,¹ T. Blydt-Hansen,³ U. Allen,¹ Y. Avitzur,¹ P. Birk,² B. Foster,⁴ H. Grasemann,¹ L. Hamiwka,⁵ R. Parekh,¹ V. Phan,⁶ S. Urschel,⁷ S. Mital.¹
¹SickKids Hospital, Toronto, ON, Canada; ²Winnipeg Children's Hospital, Winnipeg, MB, Canada; ³BC Children's Hospital, Vancouver, BC, Canada; ⁴Montreal Children's Hospital, Montreal, QC, Canada; ⁵Alberta Children's Hospital, Calgary, AB, Canada; ⁶CHU Sainte Justines, Montreal, QC, Canada; ⁷Stollery Children's Hospital, Edmonton, AB, Canada.
Background: Rejection risk varies after solid organ transplantation (SOT). We explored genomic variants associated with susceptibility to graft rejection.Methods: SOTs enrolled in a multicenter prospective…
2018 American Transplant Congress
The Efficacy and Safety of Rituximab as Induction Therapy in Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials
X. Wang,¹ J. Chen,² X. Tu,² Y. Qiu,¹ T. Song,¹ T. Lin.¹
¹Department of Urology/Institute of Urology/Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; ²West China School of Clinical Medicine, Sichuan University, Chengdu, Sichuan Province, China.
Objectives. This meta-analysis was undertaken to assess the efficacy and safety of rituximab as induction therapy in kidney transplantation.Methods. OVID, Embase, SCI, PubMed and EBSCO…
2018 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine Model
B. Swearingen,^1,2 S. Graves,^2,3 R. Storb,^2,3 D. Mathes.^1,2
¹Surgery; Division of Plastic and Reconstructive Surgery, University of Colorado School of Medicine, Aurora, CO; ²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ³Medicine, University of Washington Medical Center, Seattle, WA.
PURPOSE:Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by chronic immunosuppression and rejection. Current clinical tolerance protocols rely on recipient conditioning and…
2018 American Transplant Congress
Patients with C-aABMR and V-Lesions in Their Renal Transplant Biopsy Have a Superior Response to Treatment
K. Sablik, M. Clahsen-van Groningen, C. Looman, M. Betjes.
Erasmus Medical Center, Rotterdam, Netherlands.
Introduction Chronic active antibody mediated rejection (c-aABMR) in the renal allograft may occur with isolated arteritis. Isolated v-lesions have been associated with an inferior graft…
2018 American Transplant Congress
Preventing of Rejection of Vascularized Composite Allografts by Targeting T Cell Metabolism
B. Oh,¹ C. Cheng,² G. Furtmüller,¹ K. Donovan,¹ W. Lee,¹ J. Powell,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins SOM, Baltimore; ²Oncology, Johns Hopkins SOM, Baltimore.
[Background] Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells…
2018 American Transplant Congress
Long-Term Outcomes of Graft Function in Elderly Kidney Transplant Recipients
I. Bajjoka, A. Yaldo, C. Crombez, M. Abouljoud.
Henry Ford Transplant Institute, Detroit, MI.
Purpose: To compare and evaluate 5-year outcomes of graft function for younger (Y) versus elderly (E) kidney transplant recipients (KTR).Introduction: As the number of elderly…
2018 American Transplant Congress
Development of a Novel Assay System for Ex Vivo T-Cell Mediated Rejection Responses in Intestinal Grafts
S. Okano,^1,2 K. Abu-Elmagd,² D. Kish,¹ K. Keslar,¹ M. Fujiki,² G. Costa,² C. Miller,² W. Baldwin,¹ R. Fairchild,¹ K. Hashimoto.²
¹Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; ²General Surgery, Digestive Disease & Surgery Institute, Cleveland Clinic, Cleveland, OH.
In intestinal transplantation, the intestinal allograft (IA) presents a formidable challenge for control of alloimmune responses due to constitutive MHC class II expression by intestinal…
2018 American Transplant Congress
Thymoglobulin Induction Decreases Risk of Death in HLA-Sensitized Kidney Recipients
C. Loheac, O. Aubert, M. Assayag, D. Viglietti, C. Lefaucheur, A. Loupy.
Paris Translational Research Center for Organ Transplantation, Paris, France.
Anti-thymocyte globulin (ATG) is currently the preferential induction treatment in kidney recipients at high risk for allograft rejection. However, no study has evaluated the benefits…