2022 American Transplant Congress
Local Intragraft Humoral Immune Response in Chronic Lung Allograft Dysfunction
*Purpose: Donor HLA-specific antibody (DSA) and antibody against self-antigens (self-antigen antibody) can cause injury and lead to chronic lung allograft dysfunction (CLAD) after lung transplantation…2022 American Transplant Congress
Utility of a Holistic Molecular Paradigm for Kidney Biopsy in the Clinic
1Intermountain Medical Center, Murray, UT, 2CareDX, South San Francisco, CA
*Purpose: We report on the clinical utility of a serial dd-cfDNA (donor derived cell free DNA) monitoring coupled with Tissue Transcriptomics (Tr) and Histology (Hx)…2022 American Transplant Congress
A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients
University of Wisconsin, Madison, WI
*Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…2022 American Transplant Congress
Outcomes in Renal Transplant Recipients Receiving Pre-Transplant Financial Assistance Through the American Kidney Fund
*Purpose: Pre-transplant financial assistance for insurance premiums is available for eligible patients through the American Kidney Fund (AKF), but this funding ends within the first…2022 American Transplant Congress
Direct Comparison of Clinical Outcomes with Belatacept-Based Regimens to Calcineurin Inhibitors Among DCD and/or High KDPI Kidney Transplant Recipients
*Purpose: Belatacept, an inhibitor of the T-cell costimulatory pathway, can be used in recipients of Donation after Cardiac Death (DCD) and high Kidney Donor Profile…2022 American Transplant Congress
Month 1 Donor Derived Cell Free DNA Levels Predict Future Kidney Transplant Rejection
1Northwestern University, Chicago, IL, 2Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: The purpose of this study was to determine if donor-derived cell-free DNA (dd-cfDNA) can be used one-month post-transplant to predict later allograft rejection.*Methods: Retrospective…2022 American Transplant Congress
Impact of Delayed Graft Function in Donation After Circulatory Death Kidney Transplantation
*Purpose: Donation after circulatory death (DCD) has been associated with higher rates of delayed graft function (DGF) when compared to donation after brain death (DBD).…2022 American Transplant Congress
DEPTOR: A Novel Endothelial-Specific Regulator of Cell-Intrinsic Anti-Inflammation Following Transplantation
*Purpose: Recent studies have highlighted a paradigm whereby the maintenance of normal tissue homeostasis and the prevention of chronic inflammation is dependent on the active…2022 American Transplant Congress
A Single-Center’s Outcomes of Combined Heart-Liver Transplantation
*Purpose: The purpose of this study was to evaluate rejection outcomes in our combined heart-liver transplant (CHLT) recipients at 6 months.*Methods: This is a retrospective,…2022 American Transplant Congress
Circulating Donor-Derived Cell-Free DNA: A Novel Non-Invasive Biomarker for Immune Surveillance in Vascularized Composite Allotransplantation
*Purpose: The purpose of this study is to evaluate whether circulating donor-derived cell-free DNA (dd-cfDNA) could be used as a noninvasive biomarker to detect rejection…
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