2022 American Transplant Congress
Use of De Novo mTOR Inhibitors in Highly Sensitized Kidney Transplant Recipients
*Purpose: mTOR inhibitors (mTORi) allow calcineurin-inhibitor reduction without loss of efficacy and may improve allograft-transplant outcomes. However, the safety of this protocol in high-immunological risk…2022 American Transplant Congress
Re-Examining the Optimal Threshold for Donor Derived Cell Free DNA in Renal Allograft Rejection
*Purpose: Due to the invasive nature and potential complications of allograft biopsies, there is an important role for surrogate biomarkers to help identify rejection early,…2022 American Transplant Congress
Time-Dependent Blood Eosinophilia Count Increases the Risk of Kidney Allograft Rejection
*Purpose: There is growing evidence that type 2 immune effectors (immunoglobulin E, eosinophils, mast cells/basophils) play a role in autoimmune disorders and solid organ transplantation.…2022 American Transplant Congress
Single Kidney Transplantation Using Pediatric Donor Kidneys: Satisfactory Outcomes but Specific Attentions Needed
The First Affiliated Hospital Of Sun Yat-sen University, Guangzhou, China
*Purpose: Utilization of pediatric donor in single kidney transplantation (SKT) are popular and can greatly expand the scarce donor pool, whereas potential risk factors remain…2022 American Transplant Congress
RNA-Sequencing Analysis of Kidney Allografts Reveal Heightened NK Cell Activity in Chronic Active Antibody-Mediated Rejection
Weill Cornell Medicine, New York, NY
*Purpose: The role of NK cells is increasingly recognized in chronic active antibody mediated rejection (caABMR) of the kidney allograft. Treatment of caABMR is challenging…2022 American Transplant Congress
Unravelling the Stage-Shift of Acute Rejection by Urine QSant
1Nephrosant, Brisbane, CA, 2NephroSant, Brisbane, CA
*Purpose: Suboptimal performance in current methods for allograft monitoring underscores the unmet need for enhanced immunosurveillance accuracy, to uncover the alloimmunity flux. QSant[Yang et al,…2022 American Transplant Congress
Real-Time Biometric Monitoring Using Wearable Devices for Pediatric Heart Transplant Rejection and Infection Surveillance
*Purpose: Monitoring for acute rejection (AR) after orthotopic heart transplantation (OHTx) is primarily achieved by evaluating histological endomyocardial biopsies (EMBx). However, this procedure is limited…2022 American Transplant Congress
Impact of the High Baseline Anti-a/b Antibody Titer on the Clinical Outcomes in ABO-incompatible Living Donor Liver Transplantation
Surgery, Seoul National Bundang Hospital, Seongnam, Korea, Republic of
*Purpose: Recently, advances in desensitization protocol have made ABO-incompatible (ABOi) living donor liver transplantation (LDLT) feasible option in the era of organ shortage. Although, multiple…2022 American Transplant Congress
M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod
*Purpose: After kidney transplantation, Antibody Mediated Rejection (ABMR) is the main factor affecting the long-term survival of kidney transplantation. Previous studies have confirmed that macrophage…2022 American Transplant Congress
Monitoring Efficacy of Tocilizumab Treatment for Chronic Antibody Mediated Rejection (cAMR) in Kidney Transplants Using Donor-Derived Cell-Free DNA (dd-cf-DNA)
*Purpose: IL-6/IL-6R have emerged as important targets for treating cAMR. Recent data show that long-term treatment can stabilize eGFR, reduce DSAs and result in a…
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