Articles tagged "Rejection"

2022 American Transplant Congress
Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts
X. Lai¹, J. Wang¹, S. Han¹, C. Chunlei¹, L. VanOsdol¹, L. Gallon², J. Leventhal², M. Kandpal¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
2022 American Transplant Congress
Role of Innate Immunity in Regulating Host Responses to Ischemia and Reperfusion and Allograft Rejection Injury in Vascularized Composite Allotransplantation
S. Han¹, X. Lai², J. Wang¹, L. VanOsdol³, C. Chen¹, J. Mathew¹, J. R. Leventhal⁴, Z. Zhang⁵
¹Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Microsurgery Core, Northwestern University, Chicago, IL, ³Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Northwestern University Transplant Surgery, Chicago, IL
*Purpose: Vascularized composite tissue allotransplantation (VCA) 's wide application has been impeded by deleterious side-effect of current immunosuppressive regimens. This study is aimed to determine…
2022 American Transplant Congress
Rejection After Liver Transplantation: What Can We Learn from Transcriptomic Analysis?
H. J. Braun¹, D. Amara², A. Zarinsefat¹, G. Szabo¹, Z. Laszik¹, P. Stock¹, N. Ascher¹
¹University of California, San Francisco, San Francisco, CA, ²UCLA, Los Angeles, CA
*Purpose: Acute cellular rejection (ACR) can occur at any time following liver transplantation (LT); initial ACR within 6 months is most common and occurs in…
2022 American Transplant Congress
Diagnostic Performance of Donor-Derived Cell-Free DNA Assay (AlloSure®) in Kidney Transplant Recipients with Graft Dysfunction: A Single Center Study
M. S. Naseer¹, H. Shokouh-Amiri², T. Creamer¹, R. McMillan², S. Tandukar¹, D. Aultman¹, G. B. Zibari¹, N. Singh¹
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Circulating donor-derived cell-free DNA (dd-cf-DNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out active rejection…
2022 American Transplant Congress
Utility of Donor Derived Cell-Free DNA in Liver Transplantation
A. Zarrinpar, D. Lewis, C. Warren, S. Duarte
Surgery, University of Florida, Gainesville, FL
*Purpose: As a non-invasive measure of allograft injury, quantifying the fraction of donor-derived cell-free DNA (dd-cfDNA) has proven to be useful technique in kidney transplantation.…
2022 American Transplant Congress
Trends in Donor Derived Cell Free DNA Before and After Cellular and Antibody Mediated Rejection
K. Guo¹, J. Friedewald¹, C. Rebello¹, B. Kinsella¹, S. Park², L. Zhao¹
¹Northwestern University, Chicago, IL, ²Transplant nephrology, Northwestern University, Chicago, IL
*Purpose: The TRAC dd-cfDNA test was developed to detect acute kidney transplant rejection but can also detect subclinical rejection with improved performance in antibody-mediated rejection…
2022 American Transplant Congress
Donor-Derived Cell-Free DNA Testing in Kidney Transplantation: Do One-Month Values Have Any Prognostic Significance?
B. K. Sharda¹, M. Garner¹, A. Farney¹, G. Orlando², J. Rogers², C. Jay³, A. Daniel¹, A. Guiterrez¹, N. Sakhovskaya¹, R. Stratta¹
¹ATRIUM HEALTH Wake Forest Baptist Medical Center, Winston Salem, NC, ²Wake Forest Baptist Medical Center, Winston Salem, NC, ³Wake Forest Baptist Health, Winston-Salem, NC
*Purpose: Plasma-based donor-derived cell-free DNA (dd-cfDNA) assays have been proposed as an alternative to percutaneous renal allograft biopsy which is the current gold standard for…
2022 American Transplant Congress
Utility of Four-Point Mycophenolate Mofetil Testing in a Pediatric Kidney Transplant Population
S. Sadiq, P. Brakeman, J. Brennan, E. Black
Pediatric Nephrology, UCSF, San Francisco, CA
*Purpose: While there is randomized, multicenter data in adults that area under the time concentration curve (AUC) measurements for Mycophenolate Mofetil (MMF) can direct dosing…
2022 American Transplant Congress
Induction Immunosuppression in ABO-Incompatible Liver Transplant Recipients
S. Shaikh¹, I. Hasan¹, N. Kaur²
¹Keck Medicine of USC, Los Angeles, CA, ²Keck School of Medicine, Los Angeles, CA
*Purpose: ABO-incompatible (ABO-i) liver transplantation (LT) has been associated with an increased risk of AMR, as well as poor patient and graft survival. With advances…
2022 American Transplant Congress
Significance of C4d Expression in Peritubular Capillary Concurrent with Microvascular Inflammation in For-Cause Biopsies of ABO-Incompatible Renal Allografts
H. Cho¹, C. Baek², H. Kim³
¹Department of Pathology, Asan Medical Center, Seoul, Korea, Republic of, ²Department of Internal Medicine, Asan Medical Center, Seoul, Korea, Republic of, ³Asan Medical Center, Seoul, Korea, Republic of
*Purpose: ABO incompatible (ABOi) kidney transplantation (KT) has been increasing due to severe organ shortages. Pathologic diagnosis of antibody-mediated rejection (ABMR) in ABOi patients is…

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