Articles tagged "Rejection"

2022 American Transplant Congress
Autologous Mesenchymal Stem Cells for Treatment of Chronic Antibody-Mediated Kidney Graft Rejection: Report of the First Phase I/II Clinical Case Series
Ž. Večerić-Haler¹, M. Sever², N. Kojc³, G. Mlinšek¹, M. Oblak¹, P. Halloran⁴, A. Aleš Rigler¹, J. Buturović Ponikvar¹, M. Arnol⁵
¹Nephrology, UMC Ljubljans, Ljubljana, Slovenia, ²Haematology, UMC Ljubljans, Ljubljana, Slovenia, ³Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana,, Ljubljana, Slovenia, ⁴Division of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ⁵University Medical Centre Ljubljana, Ljubljana, Slovenia
*Purpose: The aim of this study is to evaluate the safety and efficacy of autologous mesenchymal stem cellc (MSCs) in combination with standard of care…
2022 American Transplant Congress
HLA-DRB1 and DQB1 Amino Acid Mismatches as Determinants of Kidney Allograft Failure
L. Gragert¹, K. P. McCullough², G. L. Wager³, R. Urbanowicz⁴, R. M. Merion², M. Kamoun⁴
¹Tulane Cancer Center, Tulane University, New Orleans, LA, ²Arbor Research Collaborative for Health, Ann Arbor, MI, ³Tulane University, New Orleans, LA, ⁴University of Pennsylvania, Philadelphia, PA
*Purpose: It was previously reported that HLA-DRB1 amino acid (AA) mismatches (MMs) at peptide-binding pockets of this molecule account for significant incremental risk of kidney…
2022 American Transplant Congress
A Real-World Analysis with the Molecular Microscope Diagnostic System in Dual-Organ Transplant Recipients
J. M. Blair¹, J. Van Zyl², G. P. Milligan³, S. M. McKean², R. Patel², S. A. Hall⁴, A. Alam³
¹Cardiology, Baylor University Medical Center at Dallas, Dallas, TX, ²Baylor University Medical Center at Dallas, Dallas, TX, ³Advanced Heart Failure & Transplant Cardiology, Baylor University Medical Center at Dallas, Dallas, TX, ⁴Transplant Cardiology and Mechanical Support/Heart Failure, Baylor University Medical Center at Dallas, Dallas, TX
*Purpose: The Molecular Microscope Diagnostic System (MMDx) analyzes ribonucleic acid transcripts to provide sophisticated differentiation amongst T-cell mediated rejection (TCMR), antibody mediated rejection (AMR), injury…
2022 American Transplant Congress
Of the Individual Components of a Modified Freid Frailty Score, Pre-Transplant Walk Time and Grip Strength Are the Strongest Predictors of Post Kidney Transplant Outcomes
S. Parajuli, F. Aziz, H. L. Lorden, K. A. O'Toole, R. E. Wallschlaeger, I. C. Breyer, B. Dodin, J. Goronzik Wang, D. A. Mandelbrot
University of Wisconsin, Madison, WI
*Purpose: Frailty assessment has become common during evaluation for kidney transplantation; however, a variety of different tools are used for frailty assessment. The Freid frailty…
2022 American Transplant Congress
Gm2a: A Novel Regulatory Pathway Controlling CD8⁺ T Cell Alloimmunity
K. M. Baecher¹, J. Bazzano¹, K. Tong¹, M. Fribourg², P. Cravedi², P. S. Heeger², M. L. Ford¹
¹Department of Surgery, Emory University, Atlanta, GA, ²Mount Sinai School of Medicine, New York, NY
*Purpose: Transplant recipients experience lifelong immunosuppression, yet studies have shown that a subset of patients may be able to retain stable graft function even with…
2022 American Transplant Congress
Standard Induction with Basiliximab versus no Induction in Low Immunological Risk Kidney Transplant Recipients: Study Protocol for a Randomized Controlled Trial
A. Ajlan¹, H. Aleid¹, T. Ali¹, H. Joharji¹, Z. Alabdulkarim¹, T. Aburiash¹, K. Almeshari¹, A. Nazmi¹, Y. Shah¹, E. Devol¹, D. Alkortas¹, D. Broering¹, I. Alahmadi¹, A. Ullah¹, A. Alotaibi¹, A. Aljedai²
¹KFSHRC, RIYADH, Saudi Arabia, ²MOH, RIYADH, Saudi Arabia
*Purpose: To compare different induction therapeutic strategies with 2 doses of basiliximab vs. no induction in low immunologic risk kidney transplant recipients as per KFSHRC…
2022 American Transplant Congress
Urinary Exosomal MicroRNA Biomarkers for Antibody-Mediated Rejection After Kidney Transplantation
S. Shin, M. Kim, S. Lim, H. Kwon, J. Jung, Y. Ko, H. Kwon, Y. Kim
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
*Purpose: We aimed to identify urine-derived exosomal miRNAs as diagnostic biomarkers for antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: Exosomal miRNAs using differential ultracentrifugation were isolated…
2022 American Transplant Congress
Use of Three-Dimensional Volumetric Analysis to Monitor Acute Rejection in a Face Transplant Recipient
D. Boczar¹, H. Brydges¹, O. C. Onuh¹, B. F. Chaya¹, J. Trilles¹, R. Rodriguez Colon¹, D. J. Ceradini¹, B. E. Gelb², E. D. Rodriguez¹
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: The purpose of this study is to determine the feasibility of using 3D facial stereography to monitor volume changes in a facial allograft, and…
2022 American Transplant Congress
B and Plasma Cell Populations Drive Chronic Rejection After Lung Transplantation
M. Bueno¹, N. F. Smirnova², K. Riemondy³, P. Suresh¹, M. Brown¹, X. Wang¹, S. Collins⁴, J. Sembrat¹, M. Koenigshoff¹, M. Snyder¹, J. McDyer¹, O. Eickelberg¹
¹Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, ²I2MC, INSERM UMR1297, Toulouse, France, ³Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, ⁴Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO
*Purpose: Chronic lung allograft dysfunction (CLAD) remains the major determinant of morbidity and mortality post-lung transplantation (LTx). Bronchiolitis obliterans syndrome (BOS) is the most prevalent…
2022 American Transplant Congress
Delta Changes in Donor-Derived Cell-Free DNA (dd-cfDNA) Complement the Donor Fraction in Kidney Transplant Surveillance
A. Wiseman¹, M. Jagadeesan², G. Gupta³, V. Rao⁴, M. Narayanan⁵, N. Agrawal⁶, G. Shekhtman⁶, Y. Fu⁶, K. Pinney⁶, S. Anand⁷
¹Centura Health, Denver, CO, ²George Washington University, Washington, DC, ³Virginia Commonwealth University, Richmond, VA, ⁴Medical University of South Carolina, Charleston, SC, ⁵Baylor Scott and White, Austin, TX, ⁶CareDx, Brisbane, CA, ⁷Intermountain Healthcare, Murray, UT
*Purpose: Delta changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the…