Articles tagged "Rejection"

2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…
2022 American Transplant Congress
Early Outcomes of Single Dose Eculizumab for Abo-Incompatible Living Donor Renal Transplantation
K. Heagler, M. Campara, P. Di Cocco, S. Gaitonde, I. Tang, J. Almario Alvarez, M. Spaggiari, J. Benken, C. S. Muran, B. Valdepenas, D. Pierce, I. Tzvetanov, E. Benedetti
UI Health, Chicago, IL
*Purpose: Use of ABO-incompatible (ABOi) donors increases access to living donor renal transplantation (LDRT). Conventional desensitization with plasmapheresis (PLEX) allows safe ABOi transplantation when pre-transplant…
2022 American Transplant Congress
Association of Pre-Transplant Anti A1 IgM Antibody Titers with Survival Outcomes in A2/A2B to B Kidney Transplantation
M. Fallahzadeh, D. Shaffer, A. El Chediak, I. Feurer, S. Rega, J. L. Triozzi, S. Shawar
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The new kidney allocation system implemented in 2014 has allowed blood type B recipients to receive kidneys from A2/A2B donors. Although many centers use…
2022 American Transplant Congress
Evaluating Long Term Outcomes in Kidney Transplant Patients with TruGraf Gene Expression and TRAC Dd-cfdna in the TRULO Study
P. West-Thielke, W. Ally, J. Hickey, L. Stach, J. Fleming, T. Cober, A. Kawano, I. Agboli, C. Miller, J. Holman
Eurofins Transplant Genomics, Framingham, MA
*Purpose: The aim of this study is to evaluate long term clinical outcomes in kidney transplant patients undergoing non-invasive rejection monitoring with the OmniGraf® biomarker…
2022 American Transplant Congress
Early Detection of Acute Rejection by Urine QSant is Not Confounded by Post-Transplant Time
C. Baan¹, S. Ghosh², J. Verhoeven¹, D. Hesselink¹, K. Boer¹, M. Sarwal²
¹Erasmus MC, Rotterdam, Netherlands, ²NephroSant, Brisbane, CA
*Purpose: We explore the viability of urinary biomarker-based monitoring for rejection in early days following renal transplantation.*Methods: Patients are from the Erasmus MC and received…
2022 American Transplant Congress
BiomarkeR Initiative to Advance Transplantation OutcomEs in Children (BRITE-c) Analysis
M. E. Seifert¹, L. Sheward², A. Kho², N. Rodig², V. Dharnidharka³, M. Diehl², R. B. Mannon⁴, O. Bestard⁵, T. Blydt-Hansen⁶, D. M. Briscoe²
¹University of Alabama, Birmingham, AL, ²Boston Children's Hospital, Boston, MA, ³St Louis Children's Hospital, St Louis, MO, ⁴University of Nebraska, Omaha, NE, ⁵Bellvitge University Hospital, Barcelona, Spain, ⁶BC Childrens, Vancouver, BC, Canada
*Purpose: Recent studies indicate that 25-36% of clinically stable pediatric renal transplant recipients will have subclinical rejection detected on surveillance biopsy. These findings highlight a…
2022 American Transplant Congress
Is a Single Dose of Steroids in Adult Living Donor Liver Transplant Safe? – A Cohort Analysis
M. Nunez, C. Praglin, A. M. Torres, E. Agudelo, H. Braun, C. Huang, S. Syed, J. Roberts, G. Roll
University of California San Francisco, San Francisco, CA
*Purpose: Steroids increase morbidity, and steroid avoidance (SA) has been studied in deceased donor liver transplant but, little is known about SA in living donor…
2022 American Transplant Congress
Antibody-Mediated Kidney Allograft Rejection (ABMR) Monitoring and Intervention Based on ABMR Subtypes – A Step Towards Precision Diagnosis and Management
A. Rizvi¹, S. Hussain², M. Kueht³, J. Fair³, A. Gamilla-Crudo⁴, M. Mujtaba⁴
¹Internal Medicine, Nephrology, University of Texas Medical Branch, Galveston, TX, ²University of Texas Medical Branch, Houston, TX, ³Surgery, University of Texas Medical Branch, Galveston, TX, ⁴University of Texas Medical Branch, Galveston, TX
*Purpose: The monitoring of kidney allograft for early detection of antibody mediated rejection (ABMR) and subsequent intervention using traditional clinical parameters has been insufficient due…
2022 American Transplant Congress
Study Of Matrix Metalloproteinases(MMP) And Tissue Inhibitors Of Metalloproteinases(TIMP) In Renal Transplant Recipients(RTR)- Rejectors Versus Stable Graft
J. P. Tom¹, R. Dhital², A. Sharma³, R. Aggarwal¹, R. Nada⁴, R. Ramachandran⁵, S. Anand¹, M. Minz⁶, R. Minz¹
¹Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ²Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, ³Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ⁴Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ⁵Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, ⁶Department of Renal Transplant Surgery, Fortis Hospital, Mohali, Mohali, India
*Purpose: Our study aimed to shed light on the role of serum levels of MMP and their inhibitors- TIMP in renal allograft rejection.*Methods: This was…
2022 American Transplant Congress
Regulatory Gene Pathways Are Upregulated in Heart Transplant Biopsies with Quilty Lesions
Q. Cai, L. De Las Casas, J. Torrealba
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Quilty lesions (QL) are commonly sub-endocardial lymphoid aggregates found in biopsies from heart transplants. Their appearance and presence in the cardiac tissue is still…