2022 American Transplant Congress
Microvascular Inflammation in Kidney Transplant Biopsies in the Absence of HLA-DSA Displays Intense Cytotoxic T-cell and NK Cell but Not Plasma Cell Infiltration
*Purpose: Microvascular inflammation (MVI) without evidence of HLA-donor-specific antibodies (HLA-DSA) or C4d+ deposition remains an enigmatic phenotype, which cannot be classified as antibody-mediated rejection (ABMR)…2022 American Transplant Congress
Donor-Derived Cell-Free DNA (dd-cfDNA) for Assessment of Response After Treatment of Allograft Rejection
*Purpose: Surveillance of dd-cfDNA after therapy for rejection represents a promising strategy for monitoring post-treatment response. We assessed post-rejection kinetics of dd-cfDNA among kidney transplant…2022 American Transplant Congress
The Successful Use of De Novo Belatacept with Reduced Dose Tacrolimus to Mitigate the Risks of Delayed Graft Function in Kidney Transplantation
*Purpose: The new kidney allocation system has caused increased organ travel times and therefore increased cold ischemia time. Furthermore, the change in the priority to…2022 American Transplant Congress
Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles
*Purpose: Following cell injury, donor-derived cell-free DNA (ddcfDNA) is increased in the urine of kidney transplant recipients. DNA containing urinary extracellular vesicles (uEVs) are relevant…2022 American Transplant Congress
Recipient Neutrophil Production of Myeloperoxidase is Required for NK Cell Activation During Acute Antibody Mediated Allograft Rejection
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…2022 American Transplant Congress
The Impact of Food Insecurity on Pediatric Kidney Transplant Outcomes
Pediatric Nephrology, Lurie Children's Hospital, Chicago, IL
*Purpose: We previously demonstrated a prevalence of food insecurity (FI) of 26.7% at our institution, in a pilot study of 45 pediatric kidney transplant (pedsKTx)…2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…2022 American Transplant Congress
The Correlation of Dd-cfdna and Donor Specific Antibodies in Kidney Transplant Recipients
Johns Hopkins Hospital, Baltimore, MD
*Purpose: Donor derived cell free DNA (dd-cfDNA) is increasingly being utilized to discern the presence of rejection in kidney transplant recipients (KTRs). There continues to…2022 American Transplant Congress
Safety of Stimulant Use in Heart Transplant Recipients
*Purpose: FDA-approved prescribed stimulants are purported to increase risk of cardiovascular (CV) adverse events, particularly arrhythmias and sudden cardiac death. Debate exists regarding the safety…2022 American Transplant Congress
The Relative Association of Clinical Variables and Histologic Lesions with Molecular Rejection in Kidney Transplant Biopsies
*Purpose: Availability of molecular assessment (MMDx) independent of conventional variables (time, clinical, histologic, and HLA antibody) presents an opportunity to re-assess the relative strength of…
American Transplant Congress abstracts