2021 American Transplant Congress
A Case-Match Cohort Comparison of the Safety and Efficacy of Basiliximab for Immunosuppression Holiday in Lung Transplant Patients
1Pharmacy, Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
*Purpose: Post-transplant complications related to calcineurin inhibitors (CNI) maintenance immunosuppression (MI) may require interim alternative therapies. The goal of this study is to evaluate the…2021 American Transplant Congress
Detection of Rejection in Kidney Transplant Patients Using an Algorithm That Combines Donor Fraction and Absolute Donor-derived Cell-free DNA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the plasma of renal allograft patients is a clinically validated biomarker for allograft injury and rejection. Several dd-cfDNA assays…2021 American Transplant Congress
Bortezomib for Antibody-Mediated Rejection of Renal Transplant in Youth
The Children’s Hospital of Philadelphia, Philadelphia, PA
*Purpose: The purpose of the study was to examine preliminary efficacy and tolerability of bortezomib, a protease inhibitor, in treatment-refractory antibody mediated rejection (AMR) in…2021 American Transplant Congress
Effect of HLA-DR Mismatches on Graft Outcomes of Kidney Transplant from Elderly Donors
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Human leukocyte antigen (HLA)-DR has been shown to be more immunogenic than HLA-A or -B. The impact of HLA-DR mismatches remains unclear among kidney…2021 American Transplant Congress
Comparison of Donor-derived Cell Free Dna Between Recipients with First Solitary Allograft and Regrafts
*Purpose: Donor derived-cell free DNA (dd-cfDNA) is a biomarker of immunological injury. Multiple studies have validated its utility in recipients of first solitary kidney transplants…2021 American Transplant Congress
Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation
*Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…2021 American Transplant Congress
Novel Mixed Lymphocyte Reaction Monitoring System That Predicts Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients
*Purpose: Chronic active antibody-mediated rejection (CAAMR) induced by de novo donor-specific antibodies (DSA) is the main cause of graft loss in the long-term. Currently, there…2021 American Transplant Congress
Sequential Analysis of Renal Allograft Rejection at Single Cell Resolution
*Purpose: Renal allograft anti-rejection therapies (corticosteroids (CCS) and anti-lymphocyte globulin) have been the primary treatment modalities for over six decades, yet little is known about…2021 American Transplant Congress
Donor-derived Cell-free DNA Distinguishes Acute Rejection from Other Causes of Graft Injury in Liver Transplant Recipients
*Purpose: The donor derived cell-free DNA (ddcfDNA) has emerged as strong biomarker for allograft injury, where the fraction of ddcfDNA is reported to increase in…2021 American Transplant Congress
Significance of Repeated 1r Rejections in Heart Transplantation
1Yale New Haven Hospital, New Haven, CT, 2Yale University School of Medicine, New Haven, CT
*Purpose: 1R rejection is commonly seen in routine post-transplant biopsies. While presence of occasional 1R rejection is not considered to be detrimental, the significance of…
American Transplant Congress abstracts