Articles tagged "Rejection"

2022 American Transplant Congress
Single Dose Alemtuzemab Provides Comparable Rejection Free and Infection Free Survival Compared to Double Dose Alemtuzumab. In Comparison to Alemtuzemab, Basiliximab Has Superior Infection Free Graft Survival. Results from a Steroid Sparing Transplant Group
H. Sharma, A. Odugoudar, B. Devkaran, A. Rao, A. El-Bakry, T. Gunawardhane, D. Ridgway, M. Howse, S. Mehra
Department of Transplant Surgery, Royal Liverpool University Hospital, Liverpool, United Kingdom
*Purpose: The present study investigated the short-term biopsy-proven acute rejection rates and viral infection rates amongst our protocol of single-dose Alemtuzemab (Cohort 1) versus double…
2022 American Transplant Congress
Ixazomib for Desensitization (IXADES): Results of a Phase II Clinical Trial
N. Wilson¹, S. R. Reese², L. Ptak³, F. Aziz², S. Parajuli², V. Jucaud⁴, S. Denham⁴, A. Mishra⁵, P. Hematti⁵, A. Djamali²
¹University of Wisconsin, Madison, WI, ²Medicine, University of Wisconsin, Madison, WI, ³Administration, University of Wisconsin, Madison, WI, ⁴Terasaki Institute, Los Angeles, CA, ⁵UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI
*Purpose: Ixazomib is a second-generation oral proteasome inhibitor, FDA approved for the treatment of refractory multiple myeloma. The purpose of the study was (1) to…
2022 American Transplant Congress
Spatially Resolved Molecular Profiling of Endothelial Cells in Antibody-Mediated Kidney Transplant Rejection
M. Melendez-Ferro, D. R. Kelly, M. E. Seifert
UAB School of Medicine, Birmingham, AL
*Purpose: Endothelial cells are key targets of alloimmune injury in antibody-mediated rejection (ABMR), but are challenging to study in situ using high-throughput methods. We aimed…
2022 American Transplant Congress
Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions
M. J. Ellis¹, T. Maw², E. Huang³, E. Stites⁴, F. Shihab⁵, D. C. Brennan⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, S. Kung⁸
¹Duke University, Durham, NC, ²University of Southern California, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Colorado, Aurora, CO, ⁵University of Utah, Salt Lake City, UT, ⁶Johns Hopkins School of Medicine, Baltimore, MD, ⁷CareDx, Brisbane, CA, ⁸University of California, San Francisco, San Francisco, CA
*Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
2022 American Transplant Congress
Comparative Case Study of Mycobacterium Infections in Pediatric Post Intestinal Transplant
S. Yerina¹, R. Kanthula¹, Y. Rekhtman², S. Kaufman¹, U. Ekong¹, N. Yazigi¹, T. Fishbein¹, A. Kroemer¹, C. Matsumoto¹, K. Khan¹
¹Transplant, Georgetown University Hospital, Washington, DC, ²GI and Nutrition, Prisma Health Midlands Children's Hospital, Columbia, SC
*Purpose: We describe two rare and challenging post pediatric intestinal transplant cases with both Mycobacterium (M) Abscessus and Mycobacterium (M) Immunogenum in post surgical site…
2022 American Transplant Congress
A Novel, High Throughput Droplet Digital PCR-Based Indel Quantification Method for the Detection of Circulating Donor-Derived Cell-Free DNA After Kidney Transplantation
J. G. Verhoeven¹, K. Boer¹, A. M. Peeters¹, M. C. Clahsen-van Groningen², J. I. Roodnat¹, J. van de Wetering¹, D. Nieboer³, D. A. Bost⁴, C. C. Baan¹, D. A. Hesselink¹
¹Department of Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands, ²Department of Pathology, University Medical Center Rotterdam, Rotterdam, Netherlands, ³Department of Public Health, University Medical Center Rotterdam, Rotterdam, Netherlands, ⁴JETA Molecular, Utrecht, Netherlands
*Purpose: Donor-derived cell-free DNA (ddcfDNA) is a promising minimally invasive biomarker for acute rejection (AR) in kidney transplant recipients. To assess the diagnostic value of…
2022 American Transplant Congress
Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection
A. N. Carrier, A. Crane, M. Pinedo, A. Bartosic, A. Haririan, J. R. Scalea, M. R. Weir, J. S. Bromberg
University of Maryland, Baltimore, MD
*Purpose: Donor derived cell free DNA (dd-cfDNA) and gene expression profiling offer non-invasive methods of early detection of graft injury and rejection in solid organ…
2022 American Transplant Congress
Infections Following Rejection Therapies in Solid Organ Transplant Recipients
S. Gupta¹, J. Gea-Banacloche², H. Me³, D. M. Chascsa⁴, H. R. Vikram², R. Yaman¹, L. Kodali³
¹Internal Medicine, Mayo Clinic, Scottsdale, AZ, ²Infectious Diseases, Mayo Clinic, Phoenix, AZ, ³Transplant Nephrology, Mayo Clinic, Phoenix, AZ, ⁴Hepatology, Mayo Clinic, Phoenix, AZ
*Purpose: Infections are known complications of solid-organ transplant. They are most prevalent in the first 12 months after transplant when immunosuppression is at its peak.…
2022 American Transplant Congress
HLA-DR/DQ Single Molecule Eplet Mismatch and Formation of De Novo Donor-Specific Anti-HLA Antibodies After Kidney Transplantation in Children
V. K. Sigurjonsdottir¹, K. Piburn¹, P. C. Grimm¹, B. M. Zhang²
¹Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA, ²Histocompatibility and Immunogenetics Laboratory, Stanford Blood Center, Palo Alto, CA
*Purpose: The advances in HLA typing methods and elucidation of three-dimensional molecular structures of HLA antigens in recent years have allowed analysis of donor/recipient HLA…
2022 American Transplant Congress
Impact of Low Dose Donor-Specific HLA Antibodies in Living and Deceased Donor Kidney Transplantation
H. Lee¹, I. Sun², C. Yang¹, B. Chung¹
¹Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's hospital, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine., Presbyterian Medical Center, Jeonju, Korea, Republic of
*Purpose: The prognostic value of low level preformed donor-specific antibodies (DSA) remains controversial for kidney transplantation. The aim of the present study was to investigate…