2022 American Transplant Congress
Discrepancy Rates Between Histology (HIST) and Molecular Diagnosis (MDX) of T-cell Mediated Rejection (TCMR) Depend on Choice of Bioinformatics Pipeline
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: HIST based treatment of TCMR has played a key role in the reduction of its incidence to historic lows of ~10%. MDX methods developed…2022 American Transplant Congress
De Novo Donor-Specific Antibody Development with Mycophenolate versus Azathioprine in Lung Transplant Recipients
*Purpose: The effect of mycophenolate mofetil (MMF) or azathioprine (AZA) immunosuppression (ISN) regimens on de novo donor specific antibody (DSA) formation in lung transplant recipients…2022 American Transplant Congress
Gene Expression Profiles of Peritubular Capillarits in Chronic Antibody-Mediated Rejection
*Purpose: Antibody-mediated rejection (ABMR) is one of the most significant contributors to late graft loss. Hallmark characteristics include peritubular capillaritis (ptc) and glomerulitis (g). Diffuse…2022 American Transplant Congress
Biopsy and Blood Gene Expression Profiles Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients
1Scripps Health, La Jolla, CA, 2Northwestern University, Chicago, IL
*Purpose: We analyzed serial gene expression profiles in paired blood and biopsies from kidney transplant recipients phenotyped with a comprehensive clinical algorithm. We compared disease…2022 American Transplant Congress
Influence of Converting Kidney Transplant Recipients with High Tacrolimus Variability to the Once Daily LCP Tac Formulation
Med Univ of South Carolina, Charleston, SC
*Purpose: Tacrolimus (Tac) is the cornerstone of immunosuppression used in kidney transplant recipients (KTRs). Tac high variability, low time in therapeutic range and non-adherence are…2022 American Transplant Congress
Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)
*Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…2022 American Transplant Congress
Conversion from Immediate to Extended-Release Tacrolimus (LCP-Tac) Six Months After Renal Transplantation Optimizes Safety and Efficacy
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for prevention of rejection in kidney transplant recipients (KTRs) that may have less variability and…2022 American Transplant Congress
Galectin-3 is Predictive of 30-Day Acute Rejection Following Liver Transplantation
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: Galectin-3 (Gal3) is a beta-galactoside binding lectin that plays a key role in inflammation and immune response. Studies on Gal3 in liver transplantation are…2022 American Transplant Congress
Rhinovirus Infection in Solid Organ Transplant Recipients
*Purpose: Respiratory viral infections are one of the most common infections in solid organ transplant recipients (SOTR), causing significant morbidity and mortality. Limited data is…2022 American Transplant Congress
The Role Of Combined Gene Expression Profiling And Donor-derived Cell-free Dna In Differentiating Acute Rejection In Liver Transplant Recipients
*Purpose: In our previous studies, blood-based gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) have been independently validated in liver transplant recipients (LTR) to…
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