2016 American Transplant Congress
TNT009 and Its Parental Mouse Monoclonal Antibody TNT003 Target Complement Component C1s and Effectively Block Alloantibody-Induced Classical Complement Pathway Activation – The Preclinical Experience.
Introduction. Considering the key role of the classical complement pathway as a trigger of inflammation and injury in antibody-mediated rejection (ABMR), targeted classical pathway inhibition…2016 American Transplant Congress
Effect of Inflammation on Concentration of Intracellular Tacrolimus.
Background: The use of calcineurin inhibitors improved the outcome for transplant recipients. However, acute rejection (AR) and infection remained still an unsolved problem. We evaluated…2016 American Transplant Congress
Early Post-Transplant Patient, Graft Survival and Rejection Rates Under KAS.
Background: KAS, implemented on 12/4/14, resulted in changes in recipient, donor/recipient and tx characteristics that have the potential to affect post-tx outcomes.Data and Methods: We…2016 American Transplant Congress
Better Long-Term Renal Function with Lower Incidence of Acute Rejection and Lower CMV Infection in Renal Transplant Patients Treated with a Combination of Tacrolimus and Everolimus.
Surgery - Renal Transplant Unit, Università Cattolica del Sacro Cuore, Rome, Italy.
Introduction. Recent clinical trials have shown that the combination of CNIs with Everolimus (EVE) allows CNIs minimization, which may positively impact on chronic nephrotoxicity. Aim…2016 American Transplant Congress
Treatment of Hepatitis C Viral Infection with Novel Direct Acting Antivirals in Kidney Transplant Recipients – Single Center Experience.
Kidney transplant recipients (KTRs) with Hepatitis C virus infection (HCV+ve) have higher proteinuria and inferior patient and graft survival compared to HCV negative KTRs. Due…2016 American Transplant Congress
Post-Transplant T-Cell Alloreactive Perturbation Precedes the Advent of Humoral Immunity in Kidney Transplant Patients.
Subclinical inflammation in kidney allografts is associated with worse outcome and the activation of humoral alloimmunity. Surveillance allograft biopsies are an accurate tool to diagnose…2016 American Transplant Congress
Molecular Diagnosis of Antibody-Mediated Rejection in Routine Formalin-Fixed Paraffin-Embedded Nonhuman Primate Renal Allograft Biopsies.
Background: In 2013, the Banff classification proposed molecular testing as an adjunct for the diagnosis of antibody-mediated rejection (ABMR) in renal allografts. We analyzed whether…2016 American Transplant Congress
Recipient Age and KDPI Are Potent Predictors of Early Acute Rejection in the Modern Era of Deceased Donor Kidney Transplantation.
Medicine, University of Virginia, Charlottesville, VA.
The rate of acute rejection in the first six months after deceased donor (DD) kidney transplant is about 10% in the modern era of immunosuppression.…2016 American Transplant Congress
A Quantitative CD45 Assay May Improve Diagnostic Accuracy of the Diagnosis of Acute Cellular Rejection in Transplant Kidney Biopsies.
Purpose: We have previously shown that the total inflammatory load in transplant kidney biopsies (TxBx) can be determined with a high degree of accuracy using…2016 American Transplant Congress
How Tacrolimus Variability Affects Donor Specific Antibodies, Rejection and Outcome After Kidney Transplantation.
Purpose:To investigate the effect of tacrolimus(tac) variability on the development of Donor Specific Antibodies(DSA),rejection and outcome in relation to Age, Gender, Ethnicity and Body Mass…
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