ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.

    J. Burg,1 T. Andoh,2 N. Haese,2 C. Kreklywich,2 K. Watters,3 T. Metz,3 S. Orloff,1 D. Streblow.2

    1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR; 3Biological Sciences Division, PNNL, Richland, WA.

    PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…
  • 2016 American Transplant Congress

    Effect of Early Tacrolimus Trough Variability on Graft Outcomes in Lung Transplantation.

    K. Boyle, M. Moranville, P. Shah.

    The Johns Hopkins Hospital, Baltimore, MD.

    Background: Recent data suggests that variability in tacrolimus trough levels after lung transplant may be associated with poor long term graft outcomes. The purpose of…
  • 2016 American Transplant Congress

    Early Onset Acute Antibody Mediated Rejection (ABMR) Is More Common in Female Than in Male Recipients of a Living Unrelated Donor (LURD) Renal Transplant and Is Associated with the Presence of Preformed Donor Specific Antibodies (DSA).

    D. Soonawala,1 K. Groeneweg,1 F. van der Toorn,1 S. Heidt,2 D. Roelen,2 F. Claas,2 J. de Fijter.1

    1Nephrology, LUMC, Leiden, Netherlands; 2IHB, LUMC, Leiden, Netherlands.

    Introduction: Women who receive a renal graft from their male spouse have a higher risk of early onset acute ABMR. The aim of this study…
  • 2016 American Transplant Congress

    Detection of Endothelial Cell Specific Molecule-1 According to Allograft Status After Kidney Transplantation.

    J.-W. Seo, S.-Y. Kim, Y.-G. Kim, Y.-H. Jeong, Y.-H. Lee, J.-Y. Moon, T.-W. Lee, C.-G. Ihm, S.-H. Lee.

    Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

    To investigate urine ESM-1(endothelial cell specific molecule-1) as well as plasma ESM-1 level from renal allograft recipients, we show whether there is the difference of…
  • 2016 American Transplant Congress

    Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR.

    S. Salehi, E. Reed.

    Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.

    Aim: Antibody-mediated rejection (AMR) is a major issue affecting solid organ transplants, manifesting with recruitment of monocytes to the endothelium of the allograft. The purpose…
  • 2016 American Transplant Congress

    Clinical Significance of Mycophenolic Acid Therapeutic Drug Monitoring in Kidney Transplant Recipients.

    C.-D. Kim, J.-H. Cho, K. Kim, M. Kim, W. Do, Y. Yang, T. Yim, I. Hwang, J.-H. Lee, H.-Y. Jung, J.-Y. Choi, S.-H. Park, Y.-L. Kim.

    Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.

    Background: Mycophenolic acid (MPA) is a widely used immunosuppressant to prevent acute rejection in kidney transplant recipients (KTRs). However, clinical significance of MPA therapeutic drug…
  • 2016 American Transplant Congress

    Impact of Early Acute Rejection (AR) on Pancreas Transplant (PT) Outcomes.

    V. Kirchner, T. Dunn, A. Kukla, R. Kandaswamy, E. Finger.

    University of Minnesota, Minneapolis.

    Background: The role of early AR in long-term PT outcomes remains unclear. Despite reported high rate of AR (up to 40% in PTA), graft survival…
  • 2016 American Transplant Congress

    Mechanistic Insights into How Targeting of HDAC10 Promotes Foxp3+ Treg Cell Suppressive Activity, Gene Expression and Metabolism, and Enhances Allograft Survival.

    S. Dahiya,1 L. Wang,1 U. Beier,1,2 A. Angelin,1 R. Han,1 D. Wallace,1,2 W. Hancock.1,2

    1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.

    Foxp3+ T-regulatory (Treg) cells are key regulators of immune responses that can result in unwarranted inflammation and promote allograft rejection. From a theoretical perspective, targeting…
  • 2016 American Transplant Congress

    Black Ethnicity as a Risk Factor for Poor Kidney Allograft Outcomes Post-Transplantation.

    S. Tahir,1 F. Jackson-Spence,1 H. Gillott,1 F. Everson,2 J. Nath,2 A. Sharif.2

    1University of Birmingham, Birmingham, United Kingdom; 2Queen Elizabeth Hospital, Birmingham, United Kingdom.

    Introduction: Registry studies, largely from the United States, have consistently demonstrated inferior outcomes for black patients undergoing renal transplant. A recent Canadian publication has challenged…
  • 2016 American Transplant Congress

    Clinical Significance of Isolated v1 Arteritis in Renal Transplantation.

    D. Mikhail,1,3 J. Wei,3 D. Kleinsteuber,2 M. Gabril,2,3 A. Sener,1,3 M. Moussa,2,3 P. Luke.1,3

    1Department of Surgery, Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; 2Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; 3Undergraduate Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

    INTRO: The presence of intimal arteritis (v) in renal transplant biopsies (Bx) establishes Grade II-III AVR (Acute Vascular Rejection) according to the Banff Classification. The…
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