Articles tagged "Rejection"

2016 American Transplant Congress
Mass Cytometry Reveals NK Cell and T Cell Subsets in Pediatric Liver Transplant Patients with Acute Rejection.
A. Lau,^1,2 K. Haas,¹ T. Shawler,² C. Esquivel,² O. Martinez,² R. Castillo,¹ S. Krams.²
¹Pediatrics, Stanford/LPCH, Palo Alto, CA; ²Surgery, Stanford, Palo Alto, CA.
Proper evaluation of the immune status of liver transplant recipients is crucial for appropriate post-transplant management. Current monitoring of graft function relies mainly on non-specific…
2016 American Transplant Congress
The Impact of One Year Individual or Dual Organ Rejection in Simultaneous Pancreas-Kidney Transplant on Kidney Graft Survival – A UNOS Registry Analysis 2000-2013.
I. Moinuddin,¹ T. Taber,¹ M. Yaqub,¹ O. Adebiyi,¹ M. Mujtaba,¹ J. Chen,² M. Goble,² D. Mishler,¹ J. Fridell,² A. Sharfuddin.¹
¹Medicine/Nephrology, Indiana University, Indianapolis; ²Surgery/Transplant, Indiana University, Indianapolis.
Background: Early Rejection of either organ in Simultaneous Pancreas-Kidney transplants (SPK) is common within the first 1 year. We studied the impact of within 1…
2016 American Transplant Congress
Rapamycin Nanotherapy Delays Heart Transplant Rejection.
M. Braza,¹ M. Lameijer,¹ C. Perez-Medina,¹ T. Reiner,³ M. Nahrendorf,⁴ Z. Fayad,¹ R. Duivenvoorden,¹ J. Ochando,² W. Mulder.¹
¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York; ²Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York; ³Radiology, Memorial Sloan-Kettering Cancer Center, New York; ⁴Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston.
Background:In patients, allograft survival requires a cocktail of immunosuppressive drugs, while experimentally antibodies targeting the innate immune system have been shown to induce long-term tolerance,…
2016 American Transplant Congress
Novel Function of CD4⁺ T Cell DEPTOR in Treg Homeostasis and Alloimmunity.
J. Wedel,^1,2 S. Bruneau,^1,2 K. Liu,^1,2 N. Kochupurakkal,^1,2 M. Laplante,³ D. Briscoe.^1,2
¹Division of Nephrology, Boston Children's Hospital, Boston, MA; ²Transplant Research Program, Harvard Medical School, Boston, MA; ³CRIUCPQ, Université Laval, Quebec, Canada.
DEPTOR, a recently described modulator of PI-3K/mTOR signaling, is expressed by CD4+ T cells, and functions to modulate CD4+ Teff cell differentiation. Upon CD4+ T…
2016 American Transplant Congress
Black Ethnicity as a Risk Factor for Poor Kidney Allograft Outcomes Post-Transplantation.
S. Tahir,¹ F. Jackson-Spence,¹ H. Gillott,¹ F. Everson,² J. Nath,² A. Sharif.²
¹University of Birmingham, Birmingham, United Kingdom; ²Queen Elizabeth Hospital, Birmingham, United Kingdom.
Introduction: Registry studies, largely from the United States, have consistently demonstrated inferior outcomes for black patients undergoing renal transplant. A recent Canadian publication has challenged…
2016 American Transplant Congress
Clinical Significance of Isolated v1 Arteritis in Renal Transplantation.
D. Mikhail,^1,3 J. Wei,³ D. Kleinsteuber,² M. Gabril,^2,3 A. Sener,^1,3 M. Moussa,^2,3 P. Luke.^1,3
¹Department of Surgery, Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Undergraduate Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
INTRO: The presence of intimal arteritis (v) in renal transplant biopsies (Bx) establishes Grade II-III AVR (Acute Vascular Rejection) according to the Banff Classification. The…
2016 American Transplant Congress
The Role of HLA Class II Antibody in Endothelial Cell Activation and Allograft Rejection.
G. Cantanhede,¹ V. Carter,² K. Giles,² J. Kirby,¹ S. Ali.¹
¹Institute of Cellular Medicine, University of Newcastle, Newcastle, Tyne and Wear, United Kingdom; ²Histocompatibility and Immunogenetics, National Health Service Blood and Transplant, Newcastle, Tyne and Wear, United Kingdom.
Background: Antibody-mediated rejection is one of the major causes of chronic rejection. This is mediated by endothelial cell activation, a process of endothelium microvascular inflammation…
2016 American Transplant Congress
Urinary Exosomal Annexin A1 Is a Predictive Biomarker of Post Kidney Transplant Complications.
H. Harada,¹ T. Murakami,² C. Yamamoto,² K. Hotta,¹ N. Fukuzawa,¹ M. Mitsuhashi.²
¹Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan; ²Hitachi Chemical Co. America, Ltd., Irvine, CA; ³Nanosomix, Inc., Aliso Viejo, CA.
IntroductionMonitoring of kidney allograft condition is important. We had exhibited non-invasive diagnostic modality of post-kidney transplant complications using urine exosomal and microvesicule (EMV) mRNA of…
2016 American Transplant Congress
Immunological Ageing-Related Expansion of Highly Differentiated CD4⁺CD28null T Cells Is Associated with a Lower Risk for Early Acute Rejection After Renal Transplantation.
B. Dedeoglu, R. Meijers, M. Klepper, D. Hesselink, C. Baan, N. Litjens, M. Betjes.
Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Centre, Rotterdam, Netherlands.
Background: End-stage renal disease patients have a dysfunctional, prematurely aged peripheral T-cell system. Here we hypothesized that the degree of premature T-cell ageing before kidney…
2016 American Transplant Congress
The Impact of a Novel Dual Adenosine Triphosphate-Competitive mTOR Inhibitor (TORKinib) on Alloimmunity and Transplant Survival.
D. Fantus,¹ Y. Ono,¹ S. Yokota,¹ C. Komatsu,¹ H. Turnquist,^1,2 A. Thomson.^1,2
¹Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Background: Rapamycin (RAPA), an immunosuppressive agent, inhibits the mechanistic target of Rapamycin (mTOR), the kinase subunit of two mTOR- containing complexes (mTORC1 and mTORC2). While…