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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    Preoperative Cytokine Storm in High MELD Patients Accentuates Incidence of Rejection Following Liver Transplantation.

    A. Mathur, E. Presbyskowski, E. Zorn, K. Rogers, J. Guarrera, B. Samstein, A. Griesemer, K. Halazun, T. Kato, J. Emond.

    Abdominal Transplant Surgery, Columbia University, NY, NY.

    IntroductionAcute Cellular Rejection (ACR) affects 30 percent of all liver transplants. Histologically it is characterized by cellular inflammation in the veins, bile ducts and portal…
  • 2016 American Transplant Congress

    IL-17-Producing CCR6+CD4+ Th17 Cells Drive Intestinal Allograft Rejection in Humans.

    J. Kaiser, C. Cosentino, A. Shukla, C. Desai, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    MedStar Georgetown Transplant Institute, Washington DC.

    A. Allograft rejection remains a significant source of mortality and morbidity in intestinal transplant (ITx) recipients. However, the underlying mechanisms remain unclear. The purpose of…
  • 2016 American Transplant Congress

    Allo-Specific Memory B Cell Recall Responses Are Dependent on B Cell Autophagy.

    J. Leventhal,1 M. Fribourg,2 J. Ni,1 P. Heeger.1

    1Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; 2Neurology, Icahn School of Medicine at Mount Sinai, NY, NY.

    B cells, and in particular, memory B cells (Bmem) are sources of donor specific antibodies (DSA) that cause allograft injury. Understanding requirements for Bmem function/survival…
  • 2016 American Transplant Congress

    Tailored Rabbit Anti-Thymocyte Globulin Induction (rATG) Dosing for Kidney Transplantation.

    N. Singh,1,2 A. Rossi,1 M. Savic,1 R. Rubocki,1 M. Parker,1 J. Vella.1

    1MMC, Portland, ME; 2MGMC, Augusta, ME.

    Purpose: Although rATG is the most commonly used induction immunotherapy for kidney transplantation (KT), optimal dosing remains unknown. In order to minimize adverse effects and…
  • 2016 American Transplant Congress

    A Molecular Biopsy Test for Probability of Non-Adherence.

    P. Halloran,1,3 G. Einecke,2 J. Reeve.1

    1ATAGC, Edmonton, AB, Canada; 2Hannover Medical School, Hannover, Germany; 3Department of Medicine, University of Alberta, Edmonton, AB, Canada.

    Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
  • 2016 American Transplant Congress

    Immunogenic HLA-DR Eplet Mismatches as Predictors of Transplant Glomerulopathy.

    D. Blum,1 K. Tinckam,2 M. Marrari,3 J. Kim,2 R. Sapir-Pichhadze.1

    1McGill University, Montreal, Canada; 2University Health Network, Toronto, Canada; 3University of Pittsburgh Medical Center, Pittsburgh.

    BackgroundThe number of HLA-DR eplet mismatches (eplet load) is a risk factor for the development of anti-HLA antibodies and transplant glomerulopathy (TG). In the case…
  • 2016 American Transplant Congress

    Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.

    A. Cherukuri, R. Mehta, S. Ogunde, S. Hariharan, D. Rothstein.

    UPMC, Pittsburgh.

    In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…
  • 2016 American Transplant Congress

    Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?

    L. Cendales,1 M. Levine,2 S. Bartlett,3 J. Cheeseman,1 C. Drachenberg,3 W. Hancock,4 M. Joshi,1 A. Kirk,1 F. Leoopardi,1 S. Levin,2 M. Uluer,3 A. Selim,5 M. Song,1 W. Twaddell,3 L. Wang,4 Z. Wang,2 R. Barth.3

    1Surgery, Duke University, Durham, NC; 2University of Pennsylvania, Philadelphia, PA; 3University of Maryland School of Medicine, Baltimore, MD; 4Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; 5Pathology, Duke University, Durham, NC.

    Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…
  • 2016 American Transplant Congress

    The Impact of Treating Borderline Cellular Rejections.

    R. Mustafa,1 Y. Al Azzi,1 J. Crew,1 G. Dube,1 H. Morris,1 M. Chiles,1 J. Chang,1 H. Fernandez,1 D. Cohen,1 I. Batal,2 E. Campenot,2 S. Mohan.1

    1Nephrology, Columbia University Medical Center, New York, NY; 2Pathology, Columbia University Medical Center, New York, NY.

    Introduction: Histological findings that meet the criteria for Borderline rejection (BR) as defined by the Banff Classification are frequently seen. The clinical significance of a…
  • 2016 American Transplant Congress

    Profiling of T Cell Subsets in a Primate Cardiac Transplant Model.

    N. O'Neill, T. Zhang, G. Braileanu, W. Sun, X. Cheng, C. Evans, R. Pierson, A. Azimzadeh.

    Surgery, University of Maryland, Baltimore, MD.

    Purpose: Costimulation blockade prolongs graft survival but does not induce tolerance in primates, and mechanisms of rejection are incompletely understood. Here we evaluate changes in…
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