ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rat"

  • 2016 American Transplant Congress

    A Novel Murine Orthotopic Forelimb Transplantation Model That Allows for Reliable Assessment of Post-Transplant Upper Extremity Function.

    J. Budihardjo,1 B. Kern,1,2 S. Mermulla,1 A. Quan,1 C. Cadmi,1 J. Lopez,1 J. Park,1 A. Hoke,1 W. Lee,1 S. Tuffaha,1 G. Brandacher.1

    1Plastic Surgery, Johns Hopkins Medical Institutions, Baltimore, MD; 2Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria.

    Background: Studies related to functional return for upper extremity transplantation have been limited by the lack of a functional VCA animal model. The rat hindlimb…
  • 2016 American Transplant Congress

    Effect of Adipose Tissue-Derived Mesenchymal Stem Cells in a Rat Model of Chronic Renal Allograft Rejection.

    R. Pepineli, F. Silva, P. Gouveia, G. Tavora, S. Gomes, I. Noronha.

    Renal Division, University of Sao Paulo, Sao Paulo, Brazil.

    Adipose tissue-derived mesenchymal stem cells (ASC) may represent a new strategy to prevent allograft rejection after kidney transplantation due to its immunomodulatory properties. In the…
  • 2015 American Transplant Congress

    Identification of miRNAs Associated With Induced Tolerance to Allografts

    M. Vitalone, L. Wei, C. Esquivel, S. Busque, O. Martinez, S. Krams.

    Surgery-Transplantation, Stanford University School of Medicine, Stanford, CA.

    Introduction: Although the liver is less immunogenic than other solid organs, most liver transplant recipients receive lifelong immunosuppression. Total lymphoid irradiation (TLI) is part of…
  • 2015 American Transplant Congress

    Type III Phosphodiesterase (PDE3) Inhibitor Improves Survival Rate After Ischemia Reperfusion Injury of the Liver in Rats

    T. Fujii,1 H. Obara,2 N. Fujimura,2 K. Matsubara,2 Y. Kitagawa.2

    1Surgery, Inagi Municipal Hospital, Tokyo, Japan; 2Surgery, Keio University School of Medicine, Tokyo, Japan.

    BackgroundPDE3 inhibitor (Cilostazol) has long been used as a potent inhibitor of platelet aggregation and thrombosis. Recently, there have been a report on the protective…
  • 2015 American Transplant Congress

    Stem Cell and Novel Biologic Therapies to Enhance Functional Recovery in Limb Transplantation

    K. Kniery, M. DeHart, T. Brown, S. Salgar.

    Surgery/Clinical Investigation, Madigan Army Medical Center, Tacoma, WA.

    Introduction: Unlike visceral organ transplants, vascular composite allotransplantation such as limb and face require successful nerve regeneration and reinnervation of graft motor and sensory targets…
  • 2015 American Transplant Congress

    MicroRNA let-7i Targeting IL-10 Via JAK1-STAT3 Signal Pathway Regulates Dendritic Cells Maturation Subsequently Induces Cardiac Allograft Tolerance

    J. Wu,2,3 X. Jin,1 Y. Sun,2,3 X. Liu,2,3 D. Chi,2,3 B. Yu.2,3

    1Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China; 2Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; 3Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

    Background: Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we…
  • 2015 American Transplant Congress

    Rat Forelimb Allotransplantation: A Novel Microsurgical Model for Optimized Functional Assessment After Reconstructive Transplantation

    B. Kern,1 S. Tuffaha,1 M. Khusheim,1 S. Xiang,1 G. Furtmueller,1 K. Sarhane,1 J. Park,2 A. Hoke,2 W. Lee,1 G. Brandacher.1

    1Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; 2Neurology and NeuroSurgery, Johns Hopkins University, Baltimore, MD.

    Background:Functional outcomes following vascularized composite allotransplantation (VCA) have been promising, but there is still room for improvement. Studies to investigate strategies to overcome this obstacle…
  • 2015 American Transplant Congress

    Rat dnIKK2-Treg Derived Exosomes Suppress T Cell Proliferation, Generate T Regulatory Cells and Prolong Kidney Allograft Survival

    S. Aiello, F. Rocchetta, N. Azzollini, S. Tomasoni, G. Remuzzi, M. Noris, A. Benigni.

    Istituto di Ricerche Farmacologiche Mario Negri, Ranica, Italy.

    Rat DCs, made immature by adenoviral gene transfer of dnIKK2, generated in MLR a unique population of CD4+ T regulatory cells (dnIKK2-Treg) which potently inhibited…
  • 2015 American Transplant Congress

    Proteasome Activation During Renal Cold Storage and Transplantation: A Novel Pathway for Mitochondrial Destruction?

    N. Parajuli, L. MacMillan-Crow.

    Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR.

    Purpose: Renal cold storage (CS) is considered to be an alloantigen-independent risk factor for long-term transplant outcome. The precise molecular mechanisms responsible for CS-related renal…
  • 2015 American Transplant Congress

    Complement Inhibition Via the Lectin Pathway Improves Experimental Cardiac Graft Survival

    J. Kindermann,1,2 M. Waechter,1,2 R. Bruno,1 M. Langenmayer,3 T. Dudler,4 W. Schwaeble,5 E. Kleinert,1 T. Mayr,1,2 H. Christian,2 R. Wanke,3 J.-M. Abicht,6 S. Guethoff.1

    1Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany; 2Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; 3Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany; 4Omeros Corporation, Seattle, WA; 5Department of Infection, Immunity, and Inflammation, Leicester University, Leicester, United Kingdom; 6Department of Anaesthesiology, Ludwig-Maximilians University, Munich, Germany.

    Purpose: While complement activation via both the classical as well as the lectin pathway is believed to contribute to allograft loss, their relative contribution is…
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