Articles tagged "Prophylaxis"

2021 American Transplant Congress
PDSA Model to Improve Pneumococcal Vaccine Adherence Among Kidney Transplant Candidates
J. M. Ramakrishna, L. Brumble, C. R. Libertin
Division of Infectious Diseases, Mayo Clinic, Florida, Jacksonville, FL
*Purpose: Streptococcus pneumoniae infections occur in solid organ transplant patients at a rate of 146 per 100,000 persons per year versus 11.5 per 100,000 persons…
2021 American Transplant Congress
Perioperative Anidulafungin Combined with Triazole Prophylaxis for the Prevention of Early Invasive Candidiasis in Lung Transplant Recipients
E. Sartain¹, K. Schoeppler¹, B. Crowther¹, J. B. Smith², M. Abidi³, T. J. Grazia⁴, M. Steele², T. Gleason², K. Porter², A. Gray²
¹University of Colorado Skaggs School of Pharmacy, Aurora, CO, ²Division of Pulmonary Sciences and Critical Care, University of Colorado, Denver, CO, ³Division of Infectious Disease, University of Colorado, Denver, CO, ⁴Baylor University Medical Center, Dallas, TX
*Purpose: Invasive candidiasis (IC) is a substantial cause of morbidity and mortality in lung transplant recipients (LTRs). Post-operative factors, such as prolonged hospital stay, central…
2021 American Transplant Congress
Methenamine for the Prevention of Recurrent UTIs Post-Renal Transplant
A. Bigness¹, S. Mohamed², S. Mandala¹, N. Khodieva², K. Robichaux³, H. Mohammed¹, J. Buggs⁴, A. Kumar¹, A. Brueckner⁵, L. Bowman⁵
¹Morsani College of Medicine, University of South Florida, Tampa, FL, ²College of Public Health, University of South Florida, Tampa, FL, ³Honors College, University of South Florida, Tampa, FL, ⁴Transplant Surgery, Tampa General Hospital, Tampa, FL, ⁵Department of Pharmacology, Tampa General Hospital, Tampa, FL
*Purpose: Urinary tract infections (UTIs) are a highly prevalent postoperative complication in kidney transplant recipients (KTRs), occurring in approximately 34% of patients. The common method…
2021 American Transplant Congress
Outcomes Among CMV Mismatched and Highly Sensitized Kidney Transplant Recipients Who Develop Leukopenia or Neutropenia
S. Brar¹, R. Berry², A. Raval³, Y. Tang³, F. Vincenti², N. Skartsis²
¹University of British Columbia, Vancouver, BC, Canada, ²University of California, San Francisco, San Francisco, CA, ³Merck and Co., Inc., Kenilworth, NJ
*Purpose: Kidney transplant recipients (KTRs) who receive antiproliferative agents for immunosuppression and valganciclovir for CMV prophylaxis are at high risk of developing leukopenia and neutropenia.…
2021 American Transplant Congress
Management of Drug Interactions During Protocolized Implementation of Posaconazole Immediately Post Heart Transplant
G. Waldman, C. Rogers Marks, J. Clark, A. Woo, L. Irwin, A. Gerlach, G. D. Lewis, J. A. Fishman
Massachusetts General Hospital, Boston, MA
*Purpose: Posaconazole (POSA) is a strong CYP3A4 inhibitor known to increase tacrolimus exposure by up to 4-fold. Initiation requires empiric tacrolimus dose adjustment and close…
2021 American Transplant Congress
Unquantified Blips Lead to CMV Slips – Post Transplant CMV Monitoring in High Risk Kidney Transplant Recipients
A. T. Payne¹, J. G. Timpone², A. Gilbert², B. Thomas², B. K. Lindner²
¹Georgetown University School of Medicine, Washington, DC, ²Medstar Georgetown University Hospital, Washington, DC
*Purpose: Cytomegalovirus (CMV) is a significant cause of morbidity, mortality, and graft failure after solid organ transplantation, with high risk (D+/R-) patients being the highest…
2021 American Transplant Congress
Impact of a Cmv Cell Mediated Immunity Based Protocol on Guiding Cmv Prophylaxis Following Pediatric Liver Transplantation – A Single Center Experience
G. Kalkan¹, S. Ball², L. McConnell², D. M. Desai³, A. Aqul³, P. K. Sue¹
¹Infectious Disease, University of Texas Southwestern Medical Center, Dallas, TX, ²Solid Organ Transplant Program, Children's Health, Dallas, TX, ³Solid Organ Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Cytomegalovirus (CMV) is an important cause of morbidity following pediatric orthotopic liver transplantation (OLT), especially among high risk (HR) CMV D+/R- recipients. In 2019,…
2021 American Transplant Congress
Discontinuation of Trimethoprim/sulfamethoxazole Prophylaxis Due to Hyperkalemia in Kidney Transplant Recipients
D. Pett¹, G. Malat², C. Domenico¹, R. Samudralwar¹, A. Forte¹, D. Sawinski², J. Hu¹, B. Steiner¹, J. Rashid¹, J. Trofe-Clark²
¹Pharmacy, Hospital of Univ of Pennsylvania, Philadelphia, PA, ²Penn Transplant Institute, Hospital of Univ of Pennsylvania, Philadelphia, PA
*Purpose: Trimethoprim-sulfamethoxazole (TMP-SMX) is the drug of choice for Pneumocystis jirovecii pneumonia (PJP) prophylaxis in kidney transplant recipients (KTRs), however, it can be complicated by…
2021 American Transplant Congress
Evaluating Pneumocystis Jiroveci Pneumonia Prophylaxis in Lung Transplant Recipients
J. Sharkey, K. McMurry, J. Park, C. Carlson, K. Gregg, D. Kaul, D. Lyu, L. Fitzgerald
Michigan Medicine, Ann Arbor, MI
*Purpose: The incidence of Pneumocystis jiroveci pneumonia (PJP) in lung transplant recipients (LTRs) on PJP prophylaxis is not well documented yet reported as high as…
2021 American Transplant Congress
An Unusual Viral Tropism in a Solid Organ Transplant Recipient
P. Singh, A. Bentall, C. Langstraat, A. Swanson, P. Deziel, Y. Huang, R. Razonable
Mayo Clinic, Rochester, MN
*Purpose: Cytomegalovirus (CMV) tissue-invasive disease occurs in higher proportion in CMV-mismatched kidney transplant recipients (KTxR) with no pre-existing immunity and those who are markedly immunologically-impaired.…