Articles tagged "Primates"

2019 American Transplant Congress
Anti- CD154 / CD40 Costimulation Blockade is Superior to Tacrolimus in Prolonging Survival in Pig-to-Nonhuman Primate Renal Xenotransplantation
B. P. Lovasik¹, A. J. Matar¹, C. Breeden¹, J. Jenkins², J. Tector³, S. C. Kim¹, A. B. Adams¹
¹Emory Transplant Center, Emory University, Atlanta, GA, ²Yerkes National Primate Center, Emory University, Atlanta, GA, ³University of Alabama at Birmingham, Birmingham, AL
*Purpose: Costimulation blockade strategies targeting the CD40/CD154 pathway are highly effective in preventing xenograft rejection in pig-to-nonhuman primate (NHP) transplantation models. The aim of this…
2019 American Transplant Congress
Treg And Bone Marrow Infusion Promotes Survival Of Donor Kidney Grafted Months After Disappearance Of Mixed Chimerism
K. Bruestle, P. Alonso-Guallart, E. Lopes, G. Pierre, N. Llore, H. Sakai, S. Kofman, D. Ekanayake-Alper, M. Sykes, A. Griesemer
Columbia Center for Translational Immunology, Columbia University, New York City, NY
*Purpose: Transient mixed chimerism induced with non-myeloablative conditioning in monkeys and humans induces tolerance to about 70% of donor kidney grafts transplanted at the time…
2019 American Transplant Congress
Complement Blockade in Kidney Recipients Prevents Delayed Graft Function and Antibody-Mediated Rejection in Non-Human Primates
M. Eerhart¹, J. Reyes¹, C. Blanton¹, J. Danobeitia¹, P. Chlebeck¹, L. Zitur¹, J. Coonen¹, S. Capuano¹, A. D’Alessandro¹, J. Torrealba², W. Zhong¹, Y. Yankol¹, L. Fernandez¹
¹University of Wisconsin, Madison, WI, ²UT Southwestern, Dallas, TX
*Purpose: Ischemia-reperfusion injury (IRI) leading to inflammation, complement activation, cytokine release and acute kidney injury has been implicated in the mechanism for delayed graft function…
2019 American Transplant Congress
Phenotypic and Functional Analysis of Non-Activated and Allo-Activated Eomesodermin+ CD8+ T Cells in Humans and Nonhuman Primates
A. Perez Gutierrez¹, A. W. Thomson², D. M. Metes², M. B. Ezzelarab²
¹Transplantation Institute, University of Chicago Medicine, Chicago, IL, ²Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: The T-box transcription factors Eomesodermin (Eomes) and T-bet play a critical role in differentiation and function of CD8+ memory T cells (Tmem). We have…
2019 American Transplant Congress
Novel Insights into Blocking the IL-6 / IL-6 Receptor Pathway after Pig Kidney Xenotransplantation in Baboons
H. Hara¹, G. Zhang¹, H. Iwase¹, T. Yamamoto¹, D. Ayares², D. E. Eckhoff¹, D. K. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Revivicor Inc., Blacksburg, VA
*Purpose: IL-6 plays an important role in inflammation. The aims of the study were (i) to measure IL-6 in serum in baboons that received IL-6…
2019 American Transplant Congress
TMA Development in Kidney and Heart Xenografts Treated with Anti-CD40 or Anti-CD154 Antibodies
D. H. Ma¹, H. Sasaki¹, J. M. O¹, K. Ahrens¹, D. Becerra¹, C. G. Rickert¹, D. M. Detelich¹, T. Oura¹, W. Somer¹, I. Rosales², R. N. Pierson¹, J. Markmann¹, J. C. Madsen¹, T. Kawai¹
¹Surgery, MGH, Boston, MA, ²Pathology, MGH, Boston, MA
*Purpose: Genetically modified Galactose-α 1,3-galactose knockout transgenic swine expressing human CD55 (GTKO.hCD55) are resistant to hyperacute rejection of xenografts. We compare anti-CD154 and anti-CD40 antibody-based…
2019 American Transplant Congress
Granulocyte – Colony Stimulating Factor (G-CSF) and Granulocyte – Macrophage Colony Stimulating Factor (GM-CSF) Administration Augments the Incidence of Peripheral Blood Suppressive Regulatory T Cells in Nonhuman Primates
K. Sasaki, Y. Wang, L. Lu, J. Hughs, A. W. Thomson, M. B. Ezzelarab
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF) are known to mobilize immune cells to the peripheral blood. We evaluated regulatory T cells (Treg)…
2019 American Transplant Congress
CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation
M. Song, K. Samy, Q. Gao, R. P. Davis, F. Leopard, Z. Fitch, C. Bennett, G. R. Devi, B. H. Collins, A. D. Kirk
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…
2018 American Transplant Congress
Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation
B. Ezekian, J. Kwun, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Cochran, K. Kroning, J. Yi, S. Knechtle.
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:Sensitized kidney transplant (KT) recipients have poor access to transplantation and inferior outcomes when transplanted. Conventional methods of desensitization remove donor specific antibody (DSA) temporarily,…
2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
M. Koulmanda,¹ V. Chipashivili,¹ L. Li,¹ M. Duggan,² T. Strom.¹
¹Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…