Articles tagged "Post-transplant lymphoproliferative disorder (PTLD)"

2018 American Transplant Congress
Use of Cyclin-Dependent Kinase Inhibitors to Reduce Gammaherpesvirus Reactivation
J. Hazleton,¹ L. van Dyk.²
¹Pediatrics, Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO; ²Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO.
Infection with the gammaherpesvirus EBV occurs in over 90% of humans and leads to lifelong viral latency with intermittent reactivation that is typically controlled through…
2018 American Transplant Congress
Presentation and Outcomes of Post-Transplant Proliferative Disorder at a Single Institution Pediatric Transplant Center
G. Ramos-Gonzalez,¹ A. Allain,¹ T. Agur,¹ L. O'Melia,¹ S. Staffa,² S. Burchett,¹ B. Siegele,³ O. Weinberg,³ N. Rodig,¹ R. Fawaz,¹ T. Singh,¹ D. Freiberger,¹ K. Heung Bae.¹
¹Pediatric Transplant Center, Boston Children's Hospital, Boston, MA; ²Department of Surgery, Boston Children's Hospital, Boston, MA; ³Department of Pathology, Boston Children's Hospital, Boston, MA.
Purpose: The aim of this study was to characterize features present at the time of post-transplant lymphoproliferative disorder (PTLD) diagnosis, as well as outcomes, following…
2018 American Transplant Congress
Post-Transplant Lymphoproliferative Disorder after Kidney Transplantation: A Single Institute Experience with Focus on Epstein-Barr Virus Status
P. Zhang,¹ R. King,¹ K. Ristow,² L. Cornell,¹ F. Cosio,³ T. Habermann,² M. Alexander.¹
¹Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; ²Divsion of Hematology and Oncology, Mayo Clinic, Rochester, MN; ³Divsion of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Background: Comparing to other types of solid organ transplant, the Post-Transplant Lymphopro- liferative Disorder (PTLD) in kidney transplant recipients (KTRs) is relatively rare. Due to…
2018 American Transplant Congress
Sirolimus Use Improves Cancer-Free Survival Following Transplantation: A Single Center 10-Year Analysis
P. Chen,² L. Nair,² A. Ata,² D. Conti,¹ R. Lopez-Soler.¹
¹Surgery, Section of Transplantation, Albany Medical College, Albany, NY; ²Surgery, Albany Medical College, Albany, NY.
Introduction:In previous published results, we showed that the use of Sirolimus-based immunosuppression regimens had equivalent patient and graft 10-year survival compared to historical controls maintained…
2018 American Transplant Congress
Multi-Visceral Transplant in an HIV Positive Recipient – One Year Survival
S. Nagaraju, R. Mangus, J. Fridell.
Surgery, Indiana University School of Medicine, Indianapolis, IN.
Human immunodeficiency virus (HIV) is associated with hypercoagulability and thrombotic events. Highly active anti-retroviral therapy (HAART) has improved long term survival. More patients with HIV…
2018 American Transplant Congress
Genomic Modifications Associated with Epstein Barr Virus+ Post-Transplant Lymphoproliferative Disorder
M. McPherson,¹ Y. Balachandran,¹ S. Boyd,² H. Zimmermann,³ R. Trappe,³ C. Esquivel,¹ S. Krams,¹ O. Martinez.¹
¹Department of Surgery, Stanford University School of Medicine, Stanford, CA; ²Department of Pathology, Stanford University School of Medicine, Stanford, CA; ³Department of Haematology and Oncology, DIAKO Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany.
Epstein Barr Virus (EBV) is nearly ubiquitous in the human population, yet EBV infection is typically asymptomatic. Nevertheless, immunosuppressed transplant recipients are susceptible to EBV+…
2018 American Transplant Congress
Genomic Diversity of Epstein Barr Virus in Post-Transplant Lymphoproliferative Disorder
E. Maloney,¹ V. Busque,² S. Hui,² S. Krams,^1,2 C. Esquivel,^1,2 O. Martinez.^1,2
¹Stanford Immunology, Stanford University School of Medicine, Stanford, CA; ²Department of Surgery/Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA.
Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We utilized next-generation sequencing…
2018 American Transplant Congress
The MicroRNA Landscape of EBV+ and EBV- PTLD
Y. Balachandran,¹ H. Zimmermann,² C. Esquivel,¹ S. Krams,¹ R. Trappe,² O. Martinez.¹
¹Transplant Immunology Laboratory/Division of Abdominal Transplant, Stanford University, Stanford; ²Department of Haematology and Oncology, DIAKO Ev. Diakonie-Krankenhaus Bremen, Bremen, Germany.
Post-transplant lymphoproliferative disorder (PTLD) is a potentially fatal complication of organ transplantation characterized by abnormal proliferation of lymphoid cells in the setting of immunosuppression after…
2018 American Transplant Congress
Incidence of Epstein Barr Virus (EBV) DNAemia in EBV-Seronegative Solid Organ Transplant (SOT) Recipients with EBV-Seropositive Donors
C. Burton,¹ C. Mabilangan,² J. Preiksaitis.²
¹Pediatrics, University of Alberta, Edmonton, Canada; ²Medicine, University of Alberta, Edmonton, Canada.
Purpose: Since 2002, a pre-emptive approach to post-transplant lymhoproliferative disease prevention has been used at our center that includes EBV viral load (VL) monitoring in…
2018 American Transplant Congress
Prospective Analysis of EBV+ PTLD Incidence in Pediatric Transplant Recipients in the Modern Era
O. Martinez,¹ S. Krams,¹ M. Lapasaran,¹ S. Boyd,² D. Bernstein,² C. Twist,³ K. Weinberg,² D. Gratzinger,² B. Tan,² B. Armstrong,⁴ D. Ikle,⁴ M. Brown,⁵ M. Robien,⁵ C. Esquivel,¹ The CTOTC-06 Investigators.
¹Surgery/Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford; ²Stanford University School of Medicine, Stanford; ³Roswell Park, Buffalo; ⁴Rho, Chapel Hill; ⁵NIAID/NIH, Bethesda.
Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOTC)-06 is an NIAID-sponsored…

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