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Articles tagged "Post-transplant lymphoproliferative disorder (PTLD)"

  • 2020 American Transplant Congress

    Incidence of Skin Cancer – A Long Term Outcome of Immunosuppression in Renal Transplant Recipients Associated with the Usage of Azathioprine

    H. Bheemreddy1, S. Yusuf1, N. Krishnan2, A. Imtiaz3

    1Health and Life Sciences, Coventry University, Coventry, United Kingdom, 2Renal Unit, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom, 3Department of Dermatology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, United Kingdom

    *Purpose: The main cause of mortality in Kidney Transplant Recipient’s (KTRs) is malignancy. The cancer incidence is increased by treating with immunosuppressive agents and longer…
  • 2020 American Transplant Congress

    Impact of Immunosuppression Protocol on the Incidence of EBV Viremia and PTLD in Pediatric Kidney Transplant Recipients: A Single Center Experience

    K. Bowers1, V. M. Panzarino1, A. Campos1, J. Buggs2, V. D. Bowers2

    1Pediatrics, USF, Tampa, FL, 2Transplant Surgery, TGH, Tampa, FL

    *Purpose: The purpose of this study was to evaluate the efficacy of an immunosuppression protocol change, which included avoidance of anti-thymocyte globulin for induction and…
  • 2020 American Transplant Congress

    Causal Relationship between Anti-Thymocyte Globulin Induction Therapy and Development of Monomorphic PTLD in Renal Transplant Recipients

    K. Soliman1, H. Ali2, T. Fulop1, A. Osman3, A. Halawa4

    1Medicine, Medical University of South Carolina, Charleston, SC, 2Medicine, Royal Stoke, Royal Stoke, United Kingdom, 3Medicine, Cairo University, Cairo, Egypt, 4Medicine, University of Liverpool, Liverpool, United Kingdom

    *Purpose: The aim of our study is to explore the causality between ATG and different types of post-transplant lymphoproliferative disorder (PTLD) in renal transplant recipients…
  • 2020 American Transplant Congress

    Sequence Variations of the LMP1 Protein are Detected in Pediatric Transplant Recipients and May Increase the Risk of EBV Disease

    B. Mbiribindi1, M. Arvedson1, J. Pena1, O. Hatton2, C. Esquivel1, O. Martinez1, S. Krams1

    1Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, 2Molecular Biology, Colorado College, Colorado Springs, CO

    *Purpose: Epstein-Barr virus (EBV) infects more than 90% of adults worldwide and is associated with several malignancies, including post-transplant lymphoproliferative disorder (PTLD). PTLD is a…
  • 2020 American Transplant Congress

    Epstein-Barr Virus (EBV)+ Post-Transplant Lymphoproliferative Disorder (PTLD) is Associated with Tumor CCL3/CCL4 Expression and an Increase in Tumor-Infiltrating Monocytes

    J. Toh1, F. Vallania1, W. A. Haynes1, G. Bhagat2, F. E. Craig3, S. H. Swerdlow4, T. Tousseyn5, S. M. Krams1, P. Khatri1, O. M. Martinez1

    1Stanford University School of Medicine, Stanford, CA, 2Columbia University Medical Center, New York City, NY, 3Mayo Clinic College of Medicine, Phoenix, AZ, 4University of Pittsburgh School of Medicine, Pittsburgh, PA, 5Katholieke Universiteit Leuven, Leuven, Belgium

    *Purpose: PTLD is a serious post-transplant complication that encompasses a spectrum of abnormal lymphoproliferations, including B cell lymphoma-type PTLDs. Although many are EBV-driven, a significant…
  • 2020 American Transplant Congress

    Long-Term Safety in Epstein-Barr Virus (EBV)-Seropositive Kidney-Only Transplant Recipients Treated with Belatacept (BELA) in Clinical Practice: Final Study Results from the ENLiST Registry

    C. Larsen1, F. Vincenti2, T. Kou3, C. Shadur4, B. Bresnahan5, S. Jordan6, E. S. Woodle7, N. Goes8, J. Vella9, D. Wojciechowski10, M. Polinsky3, A. Gomez-Caminero3

    1Emory University Transplant Center, Atlanta, GA, 2UCSF Transplant Center, San Francisco, CA, 3Bristol-Myers Squibb, Princeton, NJ, 4Iowa Kidney Physicians, Des Moines, IA, 5Medical College of Wisconsin, Milwaukee, WI, 6Cedars-Sinai Medical Center, Los Angeles, CA, 7University of Cincinnati, Cincinnati, OH, 8Kaiser Permanente, San Francisco, CA, 9Maine Nephrology Associates, PA, Portland, ME, 10University Hospital Kidney and Liver Transplant Clinic, Dallas, TX

    *Purpose: BELA, a selective T-cell costimulation blocker, is approved for the prophylaxis of organ rejection in EBV-seropositive adult kidney transplant recipients. In phase 3 BENEFIT…
  • 2020 American Transplant Congress

    Lifetime Survival Estimates Following Solid Organ Transplantation in the United States

    C. Graham1, M. Skeans2, Y. Ahn2, C. Watson3, A. Barlev4

    1RTI Health Solutions, Research Triangle Park, NC, 2Chronic Disease Research Group, Minneapolis, MN, 3Atara Biotherapeutics, South San Francisco, CA, 4Atara Biotherapeutics, Thousand Oaks, CA

    *Purpose: The Scientific Registry of Transplant Recipients (SRTR) contains detailed patient and graft survival data for all solid organ transplants (SOT) in the United States…
  • 2020 American Transplant Congress

    Evaluation of Infectious and Malignant Complications in Elderly Renal Transplant Recipients Receiving Alemtuzumab Compared to Basiliximab

    K. Lang1, J. Shulte1, K. Cunningham1, C. D'Agostino1, M. Kapugi1, C. Kane1, A. Novak1, J. Leventhal2

    1Department of Pharmacy, Northwestern Memorial Hospital, Chicago, IL, 2Division of Transplant Surgery, Northwestern Memorial Hospital, Chicago, IL

    *Purpose: The choice of induction immunosuppression can affect several outcomes after kidney transplant (KTx), especially for elderly recipients. For this population, there is limited data…
  • 2020 American Transplant Congress

    Epstein-Barr Virus-Specific Cytotoxic T Lymphocyte Precursors (EBV-CTLp) after Tab-cel Correlates with Response & Survival in Rituximab Relapsing or Refractory Ebv+ Posttransplant Lymphoproliferative Disease (PTLD)

    R. Shen1, N. Guzman-Becerra1, Y. Sun1, F. Forozan1, S. Prockop2, E. Doubrovina2, R. O'Reilly2, X. Li1, M. Hiremath3, L. Gamelin1, W. Navarro1, B. Aftab1

    1Atara Biotherapeutics, Thousand Oaks, CA, 2Memorial Sloan Kettering Cancer Center, New York, NY, 3Atara Biotherapeutics, South San Francisco, CA

    *Purpose: EBV+ PTLD is often a fatal disease. Tab-cel is an investigational off-the-shelf, allogeneic T-cell immunotherapy specific for EBV antigens. Functional in vivo expansion approximated…
  • 2020 American Transplant Congress

    Transplant Monitoring and PTLD Detection with B Cell Receptor Repertoire Analysis in a Large Prospective Pediatric Cohort

    K. Jackson1, O. Martinez2, S. Krams2, M. Robien3, M. Lapasaran2, B. Armstrong4, C. Twist5, K. Weinberg6, D. Gratzinger1, B. Tam1, M. Sever4, M. Brown3, D. Bernstein6, C. Esquivel2, S. D. Boyd1

    1Department of Pathology, Stanford Univ School of Med, Stanford, CA, 2Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, 3NIAID, NIH, Bethesda, MD, 4Rho, Chapel Hill, NC, 5Roswell Park, Buffalo, NY, 6Department of Pediatrics, Stanford Univ School of Med, Stanford, CA

    *Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is a…
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