Articles tagged "Polyma virus"

2021 American Transplant Congress
VP2 MRNA Distinguishes the Direct Injury and Inflammation Effects of Polyoma Virus (BK) Infection from the Cognate TCMR Response That Follows Immunosuppressive Minimization
P. F. Halloran¹, K. Famulski¹, K. S. Madill-Thomsen¹, G. Böhmig², G. Gupta³, M. Myślak⁴, O. Viklicky⁵, &. the INTERCOMEX Study Group⁶
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Medical University of Vienna, Vienna, Austria, ³Virginia Commonwealth University, Richmond, VA, ⁴Pomeranian Medical University, Szczecin, Poland, ⁵Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁶., Edmonton, AB, Canada
*Purpose: BK virus nephropathy (BKN) and T cell-mediated rejection (TCMR) are difficult to distinguish by histology but often coexist due to the necessity for immunosuppression…
2021 American Transplant Congress
Coexistence of BKPyV Lytic Infection and Viral Integration in the Development of BKPyV Diseases After Renal Transplantation
S. Yan¹, Y. Wang¹, Y. Liu¹, W. Deng¹, Z. Yan¹, J. Xu¹, C. Wu², Y. Miao¹
¹Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Departments of Urology & Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To understand the role of BK Polyomavirus (BKPyV) infection and integration in the pathogenesis of BKPyV-associated diseases.*Methods: Sixteen patients with BKPyV-associated diseases were included,…
2021 American Transplant Congress
Duration and Magnitude of BK Viremia Do Not Predict Outcome in Patients After Kidney Transplantation
E. A. Farkash¹, J. T. Rajagopal², M. Vincent², M. D. Doshi³
¹Dept of Pathology, Michigan Medicine, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Dept of Nephrology, Michigan Medicine, Ann Arbor, MI
*Purpose: BK viremia was a major cause of kidney transplant failure in the early 2000’s and remains a risk factor for subsequent rejection. The standard…
2021 American Transplant Congress
Donor-Derived Cell-Free DNA Levels Risk-Stratify Polyoma BK Viremia and Associated Clinical Events After Kidney Transplantation – Preliminary Results from ADMIRAL Study
A. Pai¹, L. Bu², J. S. Bromberg³, G. Gupta⁴, I. Moinuddin⁴, T. Alhamad⁵, V. Bowers⁶, S. Ghosh⁷, W. Tian⁷, E. Stites⁸, S. Anand⁹
¹University of Texas McGovern Medical School, Houston, TX, ²University of Minnesota, Minneapolis, MN, ³University of Maryland School of Medicine, Baltimore, MD, ⁴Virginia Commonwealth University, Richmond, VA, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷CareDx, Brisbane, CA, ⁸University of Colorado, Aurora, CO, ⁹Intermountain Medical Center, Murray, UT
*Purpose: The threshold of 10,000 copies for blood Quant BK PCR has been used as a surrogate for BK nephropathy (BKN) in kidney transplant recipients…
2021 American Transplant Congress
Transcriptomics and Proteomics Profiling of Complement Pathway (cp) Proteins in Biopsies With Polyomavirus Bk Nephropathy (bkvn)
P. Randhawa¹, F. Fei², Y. Huang¹, G. Tseng³, K. Xiao⁴
¹Departments of Pathology, Pittsburgh, PA, ²Pharmacology and Chemical Biology, Pittsburgh, PA, ³Biostatistics, Pittsburgh, PA, ⁴Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Late stage BKVN can show C4d as well as classic immune complex deposits in the tubular basement membranes (Bracamonte et al. Am J Transplant…
2021 American Transplant Congress
Immunosuppression Reduction Strategies for Polyoma BK Viremia in Kidney Transplant Patients on Belatacept-Based Immunosuppression
O. Roe¹, E. Meredith¹, A. Reid², A. Basu³
¹Emory University Hospital, Atlanta, GA, ²University of California San Francisco Medical Center, San Francisco, CA, ³Emory Transplant Center, Atlanta, GA
*Purpose: The mainstay of treatment for BK infection is immunosuppression (IS) reduction, however limited literature provides guidance for treatment of patients with a belatacept-based IS…
2021 American Transplant Congress
Development of De Novo Antibody in Renal Transplant Recipients with BK Viremia Managed with Immunosuppression Reduction
R. Hod Dvorai¹, R. Lee², P. Muluhngwi², M. Raijmakers³, A. Shetty², A. Tambur², M. Ison²
¹SUNY Upstate Medical University, Syracuse, NY, ²Northwestern University, Chicago, IL, ³University of Santiago, Santiago, Chile
*Purpose: To evaluate development of de novo donor specific antibodies (dnDSA) in Renal Transplant Recipients (RTR) with immunosuppression (IS) modulation due to BK viremia (BKV)…
2021 American Transplant Congress
Association of Donor Hepatitis C Virus Infection Status and Risk of Bk Polyomavirus Viremia After Kidney Transplantation
V. S. Potluri¹, D. E. Schaubel¹, M. E. Sise², B. P. Concepcion³, R. C. Forbes¹, E. A. Blumberg¹, D. Goldberg⁴, P. P. Reese¹, R. Bloom¹, D. Shaffer³, R. Chung², D. Sawinski¹, I. Strohben², N. Elias², A. Azhar⁵, M. Shah¹, J. Eason⁵, L. A. Binari³, M. Talwar⁵, V. Balaraman⁵, A. Bhalla⁵, B. Besharatian¹, M. Z. Molnar⁵
¹University of Pennsylvania, Philadelphia, PA, ²Massachusetts General Hospital, Boston, MA, ³Vanderbilt University Medical Center, Nashville, TN, ⁴University of Miami Miller School of Medicine, Miami, FL, ⁵Methodist University Hospital, Memphis, TN
*Purpose: Transplantation of kidneys from deceased donors with hepatitis C virus (HCV) infection into HCV-negative recipients has become more common, but some studies have suggested…
2021 American Transplant Congress
Significance of Detectable but Unquantifiable Viremias Post Renal Transplantation
M. Chaung, S. Puri, S. Bunin, Z. Mondal, O. Eletta, R. Pelletier, A. Bongu
Robert Wood Johnson University Hospital, New Brunswick, NJ
*Purpose: It is unknown whether the degree of the initial viremia following kidney (KT) or combined kidney-pancreas transplantation (SPKT) correlates with future allograft rejection or…
2021 American Transplant Congress
Dissecting the Intrarenal Immune Response to Viral Infected Cells in Pediatric BK Virus-associated Nephropathy (BKVAN)
D. M. Okamura¹, S. W. Jackson¹, V. R. Dharnidharka², J. M. Smith¹
¹Pediatric Nephrology, Seattle Children's Hospital & Research Institute, Seattle, WA, ²Pediatric Nephrology, 2St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO
*Purpose: BKVAN is not only a cause of acute renal allograft injury but is a recognized cause of chronic allograft disease and in some patients,…