Articles tagged "Polyma virus"

2021 American Transplant Congress
Transcriptomics and Proteomics Profiling of Complement Pathway (cp) Proteins in Biopsies With Polyomavirus Bk Nephropathy (bkvn)
P. Randhawa¹, F. Fei², Y. Huang¹, G. Tseng³, K. Xiao⁴
¹Departments of Pathology, Pittsburgh, PA, ²Pharmacology and Chemical Biology, Pittsburgh, PA, ³Biostatistics, Pittsburgh, PA, ⁴Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Late stage BKVN can show C4d as well as classic immune complex deposits in the tubular basement membranes (Bracamonte et al. Am J Transplant…
2021 American Transplant Congress
Immunosuppression Reduction Strategies for Polyoma BK Viremia in Kidney Transplant Patients on Belatacept-Based Immunosuppression
O. Roe¹, E. Meredith¹, A. Reid², A. Basu³
¹Emory University Hospital, Atlanta, GA, ²University of California San Francisco Medical Center, San Francisco, CA, ³Emory Transplant Center, Atlanta, GA
*Purpose: The mainstay of treatment for BK infection is immunosuppression (IS) reduction, however limited literature provides guidance for treatment of patients with a belatacept-based IS…
2021 American Transplant Congress
Development of De Novo Antibody in Renal Transplant Recipients with BK Viremia Managed with Immunosuppression Reduction
R. Hod Dvorai¹, R. Lee², P. Muluhngwi², M. Raijmakers³, A. Shetty², A. Tambur², M. Ison²
¹SUNY Upstate Medical University, Syracuse, NY, ²Northwestern University, Chicago, IL, ³University of Santiago, Santiago, Chile
*Purpose: To evaluate development of de novo donor specific antibodies (dnDSA) in Renal Transplant Recipients (RTR) with immunosuppression (IS) modulation due to BK viremia (BKV)…
2021 American Transplant Congress
Association of Donor Hepatitis C Virus Infection Status and Risk of Bk Polyomavirus Viremia After Kidney Transplantation
V. S. Potluri¹, D. E. Schaubel¹, M. E. Sise², B. P. Concepcion³, R. C. Forbes¹, E. A. Blumberg¹, D. Goldberg⁴, P. P. Reese¹, R. Bloom¹, D. Shaffer³, R. Chung², D. Sawinski¹, I. Strohben², N. Elias², A. Azhar⁵, M. Shah¹, J. Eason⁵, L. A. Binari³, M. Talwar⁵, V. Balaraman⁵, A. Bhalla⁵, B. Besharatian¹, M. Z. Molnar⁵
¹University of Pennsylvania, Philadelphia, PA, ²Massachusetts General Hospital, Boston, MA, ³Vanderbilt University Medical Center, Nashville, TN, ⁴University of Miami Miller School of Medicine, Miami, FL, ⁵Methodist University Hospital, Memphis, TN
*Purpose: Transplantation of kidneys from deceased donors with hepatitis C virus (HCV) infection into HCV-negative recipients has become more common, but some studies have suggested…
2021 American Transplant Congress
Significance of Detectable but Unquantifiable Viremias Post Renal Transplantation
M. Chaung, S. Puri, S. Bunin, Z. Mondal, O. Eletta, R. Pelletier, A. Bongu
Robert Wood Johnson University Hospital, New Brunswick, NJ
*Purpose: It is unknown whether the degree of the initial viremia following kidney (KT) or combined kidney-pancreas transplantation (SPKT) correlates with future allograft rejection or…
2021 American Transplant Congress
Dissecting the Intrarenal Immune Response to Viral Infected Cells in Pediatric BK Virus-associated Nephropathy (BKVAN)
D. M. Okamura¹, S. W. Jackson¹, V. R. Dharnidharka², J. M. Smith¹
¹Pediatric Nephrology, Seattle Children's Hospital & Research Institute, Seattle, WA, ²Pediatric Nephrology, 2St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO
*Purpose: BKVAN is not only a cause of acute renal allograft injury but is a recognized cause of chronic allograft disease and in some patients,…
2021 American Transplant Congress
BKV-Associated Urothelial Carcinoma in Patients After Renal and Extrarenal Carcinoma
A. Schwarz¹, J. Schmitz², J. Gottlieb³, C. Bara⁴, H. Haller¹, J. Braesen²
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Pneumology, Hannover Medical School, Hannover, Germany, ⁴Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Polyomavirus BK (BKV) reactivation or transmission is a wellknown problem in renal transplant (TX) patients with BKV nephropathy and interstitial cystitis. The role of…
2021 American Transplant Congress
Polyomavirus BK-Associated Nephropathy in Patients After Renal and Extrarenal Transplantation
A. Schwarz¹, J. Schmitz², J. Braesen², C. Bara³, M. Sauer⁴, H. Haller¹, J. Gottlieb⁵
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany, ⁴Department of Pediatric Hematology, Hannover Medical School, Hannover, Germany, ⁵Deparment of Pneumology, Hannover Medical School, Hannover, Germany
*Purpose: Patients with non-renal organ transplantation (TX) may suffer BK-viral nephropathy (BKVN) of their own orthotopic kidneys. We aimed to know if these patients with…
2021 American Transplant Congress
Conversion from Tacrolimus to Envarsus in Rapid Metabolizers for Prevention of BK Infection
G. Towns, G. Agarwal, C. Kew
Transplant Nephrology, UAB, Birmingham, AL
*Purpose: The incidence of BK virus infection is high among rapid metabolizers (RM) in kidney transplant (KT) patients. RM can be identified using validated and…
2021 American Transplant Congress
Transplantation of Hepatitis C Positive Kidney and Pancreas Allografts Into Hepatitis C Naïve Recipients – A Single Center Experience as a Standard of Care
K. Yadav¹, A. Padiyar², K. Zhao³, J. Rabets³, A. Jittirat², S. Sclair⁴
¹Transplant Surgery, University of Toledo Medical Center, Toledo, OH, ²Nephrology, University Hospitals Cleveland, Cleveland, OH, ³Transplant Surgery, University Hospitals Cleveland, Cleveland, OH, ⁴Gastroenterology and Hepatology, University Hospitals Cleveland, Cleveland, OH
*Purpose: Transplantation of Hepatitis C positive organs into Hepatitis C naïve recipients is rapidly gaining widespread acceptance. We report our experience with transplanting HCV D+/R-…