Articles tagged "Polyma virus"

2021 American Transplant Congress
Significance of Detectable but Unquantifiable Viremias Post Renal Transplantation
M. Chaung, S. Puri, S. Bunin, Z. Mondal, O. Eletta, R. Pelletier, A. Bongu
Robert Wood Johnson University Hospital, New Brunswick, NJ
*Purpose: It is unknown whether the degree of the initial viremia following kidney (KT) or combined kidney-pancreas transplantation (SPKT) correlates with future allograft rejection or…
2021 American Transplant Congress
Dissecting the Intrarenal Immune Response to Viral Infected Cells in Pediatric BK Virus-associated Nephropathy (BKVAN)
D. M. Okamura¹, S. W. Jackson¹, V. R. Dharnidharka², J. M. Smith¹
¹Pediatric Nephrology, Seattle Children's Hospital & Research Institute, Seattle, WA, ²Pediatric Nephrology, 2St. Louis Children’s Hospital, Washington University School of Medicine, St. Louis, MO
*Purpose: BKVAN is not only a cause of acute renal allograft injury but is a recognized cause of chronic allograft disease and in some patients,…
2021 American Transplant Congress
BKV-Associated Urothelial Carcinoma in Patients After Renal and Extrarenal Carcinoma
A. Schwarz¹, J. Schmitz², J. Gottlieb³, C. Bara⁴, H. Haller¹, J. Braesen²
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Pneumology, Hannover Medical School, Hannover, Germany, ⁴Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Polyomavirus BK (BKV) reactivation or transmission is a wellknown problem in renal transplant (TX) patients with BKV nephropathy and interstitial cystitis. The role of…
2021 American Transplant Congress
Polyomavirus BK-Associated Nephropathy in Patients After Renal and Extrarenal Transplantation
A. Schwarz¹, J. Schmitz², J. Braesen², C. Bara³, M. Sauer⁴, H. Haller¹, J. Gottlieb⁵
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany, ⁴Department of Pediatric Hematology, Hannover Medical School, Hannover, Germany, ⁵Deparment of Pneumology, Hannover Medical School, Hannover, Germany
*Purpose: Patients with non-renal organ transplantation (TX) may suffer BK-viral nephropathy (BKVN) of their own orthotopic kidneys. We aimed to know if these patients with…
2021 American Transplant Congress
Conversion from Tacrolimus to Envarsus in Rapid Metabolizers for Prevention of BK Infection
G. Towns, G. Agarwal, C. Kew
Transplant Nephrology, UAB, Birmingham, AL
*Purpose: The incidence of BK virus infection is high among rapid metabolizers (RM) in kidney transplant (KT) patients. RM can be identified using validated and…
2021 American Transplant Congress
Transplantation of Hepatitis C Positive Kidney and Pancreas Allografts Into Hepatitis C Naïve Recipients – A Single Center Experience as a Standard of Care
K. Yadav¹, A. Padiyar², K. Zhao³, J. Rabets³, A. Jittirat², S. Sclair⁴
¹Transplant Surgery, University of Toledo Medical Center, Toledo, OH, ²Nephrology, University Hospitals Cleveland, Cleveland, OH, ³Transplant Surgery, University Hospitals Cleveland, Cleveland, OH, ⁴Gastroenterology and Hepatology, University Hospitals Cleveland, Cleveland, OH
*Purpose: Transplantation of Hepatitis C positive organs into Hepatitis C naïve recipients is rapidly gaining widespread acceptance. We report our experience with transplanting HCV D+/R-…
2021 American Transplant Congress
Urine Donor-derived Cell-free is Valuable for Predicting BK Polyomavirus-associated Nephropathy in Kidney Transplant Recipients
G. Huang¹, X. Chen¹, Y. Huang¹, J. Li¹, R. Deng¹, W. Chen², J. Qiu¹, S. Deng¹, G. Chen¹, Q. Fu¹, C. Wu¹, J. Fei¹, L. Liu¹, L. Chen¹, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Our previous study has proved that urine donor-derived cell-free DNA (dd-cfDNA) can assist in the diagnosis of BK polyomavirus-associated nephropathy (BKPyVAN), but its specificity…
2021 American Transplant Congress
Treatment of Bk Virus With Intravenous Immunoglobulin in Pediatric Kidney Transplant
D. Mohammad, D. Kim, R. Baracco, G. Kapur, A. Jain
Pediatric Nephrology and Transplant Services, Children's Hospital of Michigan, Detroit, MI
*Purpose: To study the prevalence of BK viremia (BKV) and BK Virus Nephropathy (BKVN) utilizing plasma BK quantitative Polymerase Chain Reaction (qPCR) and report outcomes…
2021 American Transplant Congress
VP2 MRNA Distinguishes the Direct Injury and Inflammation Effects of Polyoma Virus (BK) Infection from the Cognate TCMR Response That Follows Immunosuppressive Minimization
P. F. Halloran¹, K. Famulski¹, K. S. Madill-Thomsen¹, G. Böhmig², G. Gupta³, M. Myślak⁴, O. Viklicky⁵, &. the INTERCOMEX Study Group⁶
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Medical University of Vienna, Vienna, Austria, ³Virginia Commonwealth University, Richmond, VA, ⁴Pomeranian Medical University, Szczecin, Poland, ⁵Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁶., Edmonton, AB, Canada
*Purpose: BK virus nephropathy (BKN) and T cell-mediated rejection (TCMR) are difficult to distinguish by histology but often coexist due to the necessity for immunosuppression…
2021 American Transplant Congress
Coexistence of BKPyV Lytic Infection and Viral Integration in the Development of BKPyV Diseases After Renal Transplantation
S. Yan¹, Y. Wang¹, Y. Liu¹, W. Deng¹, Z. Yan¹, J. Xu¹, C. Wu², Y. Miao¹
¹Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Departments of Urology & Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To understand the role of BK Polyomavirus (BKPyV) infection and integration in the pathogenesis of BKPyV-associated diseases.*Methods: Sixteen patients with BKPyV-associated diseases were included,…