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Articles tagged "Polyma virus"

  • 2016 American Transplant Congress

    Incidence of Polyoma Virus Associated Nephropathy in a Single Transplant Center Employing a Reduction of Immunosuppression at a Lower Threshold of BK Viremia.

    M. Azar, A. Valika, D. Banach, I. Hall, M. Malinis.

    Internal Medicine, Infectious Diseases, Yale University, New Haven, CT.

    BackgroundPolyoma virus associated nephropathy (PyVAN) caused by BK virus (BKV) is a major complication occurring in 1-10% of renal transplant recipients. Screening and reduction of…
  • 2015 American Transplant Congress

    The Role of Quantitative Assay of Urinary Decoy Cells as a Screening and Follow-Up Tool in Renal Transplant Recipients With Polyomavirus BK Infection

    G. Huang, J. Qiu, C.-X. Wang, J.-G. Fei, S.-X. Deng, J. Li, G.-D. Chen, Q. Fu, R.-H. Deng, L.-Z. Chen.

    Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    Polyomavirus BK nephropathy (BKVN) is an important infectious complication in kidney transplant patients. Urinary cytology is effective for early diagnosis of BKVN. However, quantitative assay…
  • 2015 American Transplant Congress

    Reduced Intensity Immunosuppression Protocol Lowers Drug Costs and May Decrease Incidences of BK Viremia and Readmissions After Kidney and Kidney/Pancreas Transplant

    M. Mariski,1 A. DeGolovine,2 W. Dar,2 J. Bynon,2 H. Adrogué,2 M. Hobeika.2

    1Dept of Pharmacy, Memorial Hermann Texas Medical Center, Houston, TX; 2Division of Immunology and Organ Transplantation, University of Texas, Houston, TX.

    Purpose: To evaluate the effects of a reduced intensity immunosuppression protocol on drug costs and rates of BK viremia and readmissions.Methods: In response to high…
  • 2015 American Transplant Congress

    Incidence and Outcomes of Polyomavirus Infection in 639 Kidney Transplant Recipients: Are High Immunological Risk Characteristics More Relevant Than Specific Induction Or Maintenance Immunosuppressive Regimens?

    E. Favi,1 L. Harris,2 J. Worsfold,2 R. Cacciola,1 C. Puliatti,1 C. Sammartino,1 R. Sivaprakasam.1

    1Transplantation, Royal London Hospital, London, United Kingdom; 2Barts and The London School of Medicine and Dentistry, London, United Kingdom.

    Introduction. Polyomavirus-associated nephropathy (PVAN) is now recognized as an important cause of graft dysfunction and early kidney transplant loss. Over-immunosuppression is the main risk factor…
  • 2015 American Transplant Congress

    Histological Analysis in ABO-Compatible and Incompatible Kidney Transplantation By Performing 3-Month and 1-Year Protocol Biopsies

    K. Masutani,1 A. Tsuchimoto,1 Y. Matsukuma,1 K. Kurihara,2 Y. Okabe,2 H. Kitada,2 M. Tanaka,2 T. Kitazono,1 K. Tsuruya.1

    1Department of Medicine and Clinical Science, Kyushu University, Fukuoka, Japan; 2Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan.

    Background. ABO incompatible kidney transplantation (ABO-I KTx) is nowadays a well-established procedure to expand living donor source. Graft and patient survivals of ABO-I KTx were…
  • 2015 American Transplant Congress

    Correlates of Clinical Course of Polyomavirus BK Infection With Long-Term Outcome of BK Virus-Associated Nephropathy in Renal Transplant Patients

    G. Huang, C.-X. Wang, J.-G. Fei, J. Qiu, S.-X. Deng, J. Li, G.-D. Chen, Q. Fu, R.-H. Deng, L.-Z. Chen.

    Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    Background: Identification of risk factors for the long-term outcome of BK virus (BKV) -associated nephropathy(BKVAN) may improve renal transplant outcome. Methods: Between 2006 and 2014,…
  • 2015 American Transplant Congress

    Clinicopathological Scenarios (CPS) Defined by Viremia, Creatinine and Histology in Polyomavirus Nephropathy Differ in 1st and 2nd (Follow-Up) Biopsy

    C. Drachenberg, M. Chaudhry, F. Yang, R. Ugarte, A. Haririan, M. Mavanur, C. Cangro, B. Thomas, N. Costa, E. Ramos, M. Weir, J. Papadimitriou.

    Pathology and Medicine, University of Maryland School of Medicine, Baltimore, MD.

    Studies of sequential kidney biopsies (KB) after the diagnosis of polyomavirus allograft nephropathy (PVN) are scarce and clinicopathological evolution of PVN poorly understood. In practice…
  • 2015 American Transplant Congress

    Plasmapheresis – A Previously Unrecognised Risk Factor for BK Viraemia

    E. Olayos,1 K. Barraclough,2 R. Walker,3 R. Masterson,2 H. Peter,2 C. Solomon.4

    1St Vincents Hospital, Fitroy, Victoria, Australia; 2Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia; 3Nephrology, The Alfred Hospital, Prahran, Victoria, Australia; 4Nephrology, Western Hospital, Footscray, Victoria, Australia.

    BK nephropathy is an important preventable cause of graft loss, with the only universally accepted risk factor being overall burden of immunosuppression. In the absence…
  • 2015 American Transplant Congress

    Concerted T-Cell Activity Against Early and Late BKV-Antigens Is Necessary for Viral Clearance

    B. Weist,1,2 M. Schmueck,2 M. Dziubianau,2 P. Reinke,1,2 N. Babel.1,2

    1Department of Nephrology, Charite Universitaetsmedizin, Berlin, Germany; 2BCRT, Charite Universitaetsmedizin, Berlin, Germany.

    Polyomavirus-BK (BKV) associated nephropathy is a known cause of graft failure. No specific therapy is established so far and viral load monitoring accompanied by adjustment…
  • 2015 American Transplant Congress

    Impact of Sirolimus on the Risk of BK Viremia in Simultaneous Pancreas-Kidney Transplant Recipients

    D. Wojciechowski, T. Yokoyama, S. Chandran, P. Stock.

    UCSF, San Francisco.

    BackgroundBK virus (BKV) is a common infection in simultaneous pancreas-kidney (SPK) transplant recipients. Data in kidney transplant recipients suggest that immunosuppression regimens containing an mTORi…
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