Articles tagged "Polyma virus"

2016 American Transplant Congress
25-Hydroxyvitamin D Insufficiency Is Associated with Higher Risk of BK Virus Re-Activation After Kidney Transplantation.
N. Elfadawy,¹ S. Flechner,² E. Poggio,² B. Stephany,² R. Fatica,² J. Schold,² S. Mossad.²
¹Internal Medicine, Case Western Reserve University, Cleveland, OH; ²Cleveland Clinic, Cleveland, OH.
BACKGROUND: The past decade has seen increased interest in vitamin D, as new data suggest that it plays a role in the immune system. The…
2016 American Transplant Congress
Evaluating Posttransplant BKV-Specific T Cell Responses in Patients with Alemtuzumab Induction and Belatacept-Based Regimen.
M. McRae, T. How, A. Kirk, H. Xu.
Department of Surgery, Duke University, Durham, NC.
Belatacept-based maintenance regimens prevent acute allograft rejection following alemtuzumab induction, and patients so treated maintain intact anti-CMV and -EBV T cell immune responses without viral…
2016 American Transplant Congress
BK Polyomavirus Seroreactivity of Kidney Donors Predicts Viremia and Nephropathy in Recipients.
H. Wunderink,¹ E. van der Meijden,¹ C. van der Blij-de Brouwer,¹ M. Mallat,² G. Haasnoot,³ E. van Zwet,⁴ E. Claas,¹ J. de Fijter,³ A. Kroes,¹ F. Arnold,⁵ A. Touzé,⁵ F. Claas,³ J. Rotmans,³ M. Feltkamp.¹
¹Medical Microbiology, LUMC, Leiden, Netherlands; ²Nephrology, LUMC, Leiden, Netherlands; ³Immunohematology and Blood Transfusion, LUMC, Leiden, Netherlands; ⁴Medical Statistics and Bioinformatics, LUMC, Leiden, Netherlands; ⁵UMR INRA 1282 ISP, Université François Rabelais, Tours, France.
Background Kidney transplant (KTx) donors are not implicated in predicting BK polyomavirus (BKV) infection in the recipient. For BKV-associated nephropathy (BKVAN) however, donor origin of…
2016 American Transplant Congress
Incidence and Factors Associated with De Novo DSA After BK Viremia in Renal Transplant Recipients.
S. Patel, S. Kuten, R. Knight, D. Nguyen, E. Graviss, A. Gaber.
Houston Methodist Hospital, Houston, TX.
Recent literature indicates an elevated rate of de novo DSA (dnDSA) following BK viremia (BKV) in renal transplant recipients (RTR). We sought to review our…
2016 American Transplant Congress
Immune Response to BK Virus in Renal Transplant Recipients.
D. DeWolfe,¹ J. Gandhi,¹ M. Mackenzie,¹ T. Broge,¹ E. Bord,¹ D. Mandelbrot,¹ R. Viscidi,² F. Cardarelli,¹ M. Pavlakis,¹ C. Tan.¹
¹Medicine, Beth Israel Deaconess Medical Center, Boston, MA; ²Pediatrics, Johns Hopkins Medical Center, Baltimore, MD.
Background: The adaptive immune characteristics associated with BK Virus (BKV) infection and control remain incompletely described. In this study we further elucidate the immune response…
2016 American Transplant Congress
Identification of Donor HLA-Specific Antibodies as a Risk Factor for Graft Dysfunction and Failure Following BK Virus Associated Nephropathy.
E. Abuhelaiqa, S. Salvatore, J. Lee, J. Lee, V. Sharma, T. Muthukumar, S. Seshan, M. Suthanthiran, D. Dadhania.
Transplantation Medicine, Weill Cornell Medicine, New York, NY.
Background: BK virus associated nephropathy (BKVN) has emerged as a significant cause of graft dysfunction and graft failure. Identification of risk factors for graft dysfunction…
2016 American Transplant Congress
Influence of the Tacrolimus Metabolism Rate on BKV Infection After Kidney Transplantation.
G. Thölking,¹ C. Schmidt,¹ K. Schuette-Nuetgen,¹ D. Pabst,¹ R. Koch,² H. Wolters,³ S. Reuter,¹ B. Suwelack.¹
¹Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Münster, Münster, Germany; ²Institute of Biometrics and Clinical Research, University of Münster, Münster, Germany; ³Department of General Surgery, University Hospital of Münster, Münster, Germany.
Introduction: BK virus (BKV) infection is a serious complication following renal transplantation (RTx). The minimization of risk factors that predict BKV infection might help to…
2016 American Transplant Congress
Slipping Through the Cracks: Late Onset BK Viremia.
J. Gandhi,¹ M. Mackenzie,¹ D. DeWolfe,² F. Cardarelli,³ M. Pavlakis,³ C. Tan.^1,4
¹Center for Virology & Vaccine Research, Beth Israel Deaconess Medical Center (BIDMC), Boston, MA; ²Division of Nephrology, BIDMC, Boston, MA; ³The Transplant Institute, BIDMC, Boston, MA; ⁴Division of Infectious Disease, BIDMC, Boston, MA.
Introduction: Most studies indicate that viremia caused by BK virus (BKV), the step preceding BKV associated nephropathy (BKVN) in kidney transplant recipients (KTRs), occurs within…
2016 American Transplant Congress
BK Nephropathy, but Not Isolated BK Viremia Associated with De Novo DSA Despite Similar Immunosuppression Reduction.
W. Cheungpasitporn,¹ D. Mitema,¹ H. Amer,¹ F. Cosio,¹ M. Stegall,² C. Schinstock.¹
¹Nephrology and Hypertension, Mayo Clinic, Rochester, MN; ²Transplantation Surgery, Mayo Clinic, Rochester, MN.
Introduction: Reduced immunosuppression is associated with de novo DSA (dn DSA). Although immunosuppression is often reduced in patients with polyomavirus (BK), the incidence of dn…
2016 American Transplant Congress
Neutrophil-to-Lymphocyte Ratio as a Predictor of Polyomavirus BK Nephropathy in Kidney Transplant Patients.
K. Masutani,¹ A. Tsuchimoto,¹ Y. Matsukuma,¹ K. Kaku,² K. Kurihara,² Y. Okabe,² K. Tsuruya,¹ M. Nakamura,² T. Kitazono.¹
¹Department of Medicine and Clinical Science, Kyushu University, Fukuoka, Japan; ²Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan.
Background: Neutrophil-to-lymphocyte ratio (NLR) is an index for systemic inflammatory response, and has been reported to be a prognostic marker in the patients with malignancies…