Articles tagged "Pediatric"

2018 American Transplant Congress
Single-Dose Pharmacokinetics and Pharmacodynamics of Belatacept in Adolescent Kidney Transplant Recipients
A. Moudgil,¹ V. Dharnidharka,² D. Feig,³ B. Warshaw,⁴ V. Perera,⁵ B. Murthy,⁵ M. Roberts,⁵ M. Polinsky,⁵ R. Ettenger.⁶
¹Children's National Medical Center, Washington, DC; ²Washington University, St. Louis, MO; ³University of Alabama, Birmingham, AL; ⁴Emory University & Children's Healthcare of Atlanta, Atlanta, GA; ⁵Bristol-Myers Squibb, Lawrenceville, NJ; ⁶University of California, Los Angeles, CA.
Purpose: To assess the pharmacokinetics (PK) and pharmacodynamic (PD) effect of a single dose of belatacept (bela) administered to adolescent kidney transplant recipients (KTR).Methods: In…
2018 American Transplant Congress
Assessment of Anti-CMV Immunity by Monitoring Anti-CMV Antibody (CMV-Ab) and CMV-Specific Cytotoxic T Cells (CMV-Tc) in Pediatric Kidney Transplant Recipients (Ped KTx Pts)
B. Shin,¹ H. Pizzo,² S. Jordan,² D. Lovato,¹ A. Petrosyan,¹ D. Puliyanda,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: CMV infection results in significant morbidity in KTx pts, especially CMV sero- ped pts with CMV sero+ donors (D+/R-). CMV infection is controlled primarily…
2018 American Transplant Congress
Oral Health Related Quality of Life for Children with Kidney Disease
P. Verghese,¹ J. Sotillo,² J. Diaz,¹ E. Sarwas.²
¹Department of Pediatrics, University of Minnesota, Minneapolis; ²University of Minnesota Dental School, Minneapolis.
Children with kidney disease experience general health deficiencies that may affect their oral health and consequently their quality of life (QOL). Recent studies show a…
2018 American Transplant Congress
De Novo Donor Specific Antibodies in Pediatric Kidney Transplant Recipients Are Highly Responsive to Therapy
V. Sigurjonsdottir, P. Grimm.
Pediatric Nephrology, Lucile Packard Children´s Hospital, Palo Alto, CA.
Background: Pediatric Kidney transplant recipients who develop dnDSAs are at increased risk of allograft loss and rapid decline in GFR. C1q+ DSA, in particular, is…
2018 American Transplant Congress
Low Kidney Supply to Demand Ratio and Multi-Organ Transplant Centers Are Negatively Associated with Pediatric Renal Transplant Rates Post Kidney Allocation System Implementation: An Analysis of OPTN Data
P. Almond,¹ S. Al-Akash,¹ D. Stewart,² A. Robinson.²
¹CPSST Departments of Surgery and Renal Transplantation, Driscoll Children's Hospital, Corpus Christi, TX; ²UNOS, Richmond, VA.
Under the new kidney allocation system (KAS), pediatric (PED) renal (REN) transplant (Tx) candidates have priority to kidneys from donors with KDPI < 35%. We…
2018 American Transplant Congress
Long Term Histologic Allograft Health is Preserved Despite Rejection during Protocolized Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant Recipients
V. Venkat,¹ J. Bucuvalas,² M. Martinez,³ K. Spain,⁴ G. Mazariegos,¹ A. Demetris,⁵ S. Feng.⁶
¹Children's Hospital, Pittsburgh; ²CCHMC, Cincinnati; ³Columbia, NY; ⁴Rho, Chapel Hill; ⁵UPMC, Pittsburgh; ⁶UCSF, San Francisco.
Background: Long term allograft health after rejection during ISW has not been previously assessed. We compare baseline and 4yr graft histology of 20 rejectors in…
2018 American Transplant Congress
The Impact of the Influenza Vaccine on Pediatric Kidney Transplant Outcomes
M. Camerino,¹ S. Jackson,² S. Chinnakotla,³ P. Verghese.¹
¹Department of Pediatrics, University of Minnesota, Minneapolis, MN; ²Fairview Health Services, Minneapolis, MN; ³Department of Surgery, University of Minnesota, Minneapolis, MN.
The influenza vaccine has been associated with de novo DSA and rejection in adult kidney recipients. This risk has not been adequately assessed in pediatric…
2018 American Transplant Congress
Large Volume Intraoperative Fluid Use in Small (<20kg) Renal Recipients is Safe
N. Liow,¹ N. Mudalige,² N. Melhem,¹ S. Boyle,¹ N. Kessaris,¹ H. Hume-Smith,¹ S. Marks,¹ N. Mamode,¹ J. Stojanovic.¹
¹Paediatric Nephrology Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; ²University College London, London, United Kingdom.
INTRODUCTION: With advances in surgical and medical transplantation, progressively younger children are being transplanted. There is no consensus and little evidence on the optimal intraoperative…
2018 American Transplant Congress
Distribution of Biopsy Proven Acute Rejection in a Large Pediatric Kidney Transplant Program: A Four Year Experience
C. Varnell, Jr.,¹ A. Carle,^2,3 D. Hooper.^1,2,3
¹Division of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ³Department of Pediatrics, University of Cincinnati, Cincinnati, OH.
Introduction: Kidney biopsy is the gold standard for diagnosing rejection, transplant glomerulopathy, and other pathology after transplantation. We aimed to understand the distribution of Banff…
2018 American Transplant Congress
Psychosocial Assessment of Candidates for Transplantation (PACT) Identifies Non-Adherence in Pediatric Kidney Transplantation
K. Freischlag,¹ V. Chen,² S. Nagaraj,² A. Chua,² E. Chambers.²
¹School of Medicine, Duke University, Durham, NC; ²Pediatrics, Duke University, Durham, NC.
Background: We have demonstrated that overall pre-transplant Psychosocial Assessment of Candidates for Transplantation (PACT) scores can identify high risk pediatric kidney recipients. In this pilot…