Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Purpose: Few programs use kidneys from donors with body weight (BW) less than 10 kg or less than 8 months of age, for fear of complication and inadequate renal functional capacity.
Objective: We hypothesized that pediatric en bloc transplants from donors with body weight (BW) less than 10 kg, or less than 8 months of age would provide similar transplant outcomes to larger grafts.
Methods: All pediatric en bloc renal transplants performed at our center between 2001 and 2017 were reviewed (N=28). In 2010, we started to use donors smaller than 10 kg or younger than 8 months. All donors < 8 months were less than 10 kg. Data were stratified by donor BW less than (N=11) or greater than 10 kg (N=17). Demographic data of the donors and recipients were compared by donor BW. Outcomes included graft failure and delayed graft function. Renal volume was assessed during annual follow-up by ultrasound.
Results: Demographic characteristics were similar between the two groups of recipients. The 4 youngest donors utilized were 2 weeks old or younger and the oldest was 4 years old. After mean follow-up of 44 months for smaller donors and 124 for larger donors, graft and patient outcomes were similar between both groups. Mean serum creatinine at 1, 3, and 5 years was 100, 90, and 82 umol/L in the smaller group which was no different from the larger group at 102, 89, and 79, respectively. At 1-day post-transplant mean total renal volume in the smaller group was 50 ± 23 cm3 while in the larger group it was 99 ± 39 cm3 (P < 0.01). By 3 weeks, it was 73 ± 18 cm3 and 143 ± 47 cm3 in the smaller and larger groups respectively (P < 0.01). At 1 year post-transplant, mean renal volume was 125 ± 75 cm3 and 216 ± 58 cm3 (P = NS). Complication rates were similar between both groups with one case of venous thrombosis in the smaller group.
Conclusion: Pediatric en bloc renal transplantation from very small donors is a potential source of additional renal allografts. With experience, outcomes are equivalent to pediatric en bloc allografts from larger pediatric donors.
CITATION INFORMATION: Aquil S., Mitrou N., McAlister V., Sener A., Luke P. Transplantation of Very Small Pediatric En Bloc Renal Allografts from Donors Less Than 8 Months of Age Have Similar Outcomes to Donors More Than 8 Months Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Aquil S, Mitrou N, McAlister V, Sener A, Luke P. Transplantation of Very Small Pediatric En Bloc Renal Allografts from Donors Less Than 8 Months of Age Have Similar Outcomes to Donors More Than 8 Months [abstract]. https://atcmeetingabstracts.com/abstract/transplantation-of-very-small-pediatric-en-bloc-renal-allografts-from-donors-less-than-8-months-of-age-have-similar-outcomes-to-donors-more-than-8-months/. Accessed March 1, 2021.
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