Articles tagged "Oxidant stress"

2018 American Transplant Congress
Dehydropeptidase-Iinhibitor Reduces Tacrolimus-Induced Kidney Injury by Anti-Oxidative and Anti-Apoptotic Effect
K. Luo,¹ S. Lim,¹ J. Il,¹ Y. Shin,¹ E. Ko,^1,2 B. Chung,^1,2 H. Hwang,^1,2 C. Yang.^1,2
¹Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea.
Background:Cilastatin is an inhibitor of dehydropeptidase-I which enhances the antibacterial activity of imipenem.Dehydropeptidase I is associated with not only the metabolism of the enzyme but…
2018 American Transplant Congress
Effect of Conversion to CTLA4Ig Treatment on Tacrolimus-Induced Diabetic Rats
J. Il,¹ L. Jin,¹ K. Luo,¹ S. Lim,¹ Y. Shin,¹ E. Ko,^1,2 B. Chung,^1,2 C. Yang.^1,2
¹Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea.
Background: The effect of conversion to cytotoxic T-lymphocyte-associated protein 4 immunoglobulin (CTLA4Ig) treatment on tacrolimus (TAC)-induced renal dysfunction is well known, but its effect on…
2017 American Transplant Congress
Gene Editing of Keap1/Nrf2 in Human T Cells Using CRISPR-Cas9 to Improve Outcome from Ischemia Reperfusion Injury and Other T Cell Mediated Diseases.
S. Noel,¹ S. Lee,¹ M. Sadasivam,² A. Hamad,² H. Rabb.¹
¹Department of Medicine, Johns Hopkins University, Baltimore, MD; ²Department of Pathology, Johns Hopkins University, Baltimore, MD
Background: T lymphocytes are important mediators of ischemia reperfusion injury (IRI) during organ transplantation. Using genetically engineered mice, we demonstrated that augmentation of Nrf2 dependent…
2017 American Transplant Congress
Omega 3 Attenuates Ischemia Reperfusion Renal Injury via Enhancement of Autophagy Flux.
J.-J. Kim,¹ J. Jeong,² D. Choi,³ K. Na,³ K. Lee.³
¹Chungnam National University, Anatomy, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea; ³Chungnam National University, Nephrology, Daejeon, Korea
Purpose: Omega 3 fatty acid showed the protective effect against various renal injuries. Recently, it is reported that Omega 3 regulates the autophagy. Using fat-1…
2017 American Transplant Congress
Neuropeptide PACAP Prevents Hepatocyte Damage by Promoting Yes-Associated Protein (YAP) in Mouse Liver Ischemia/Reperfusion Injury.
Y. Liu,^1,2 C. Zhang,^1,3 R. Busuttil,¹ J. Kupiec-Weglinski,¹ Q. Xia,^1,2 H. Ji.¹
¹Department of Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA; ²Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University, Shanghai, China; ³Liver Surgery, 1st Affiliated Hospital, Zhejiang University, Hangzhou, China
Background: Yes-associated protein (YAP), a regulator of cellular anti-oxidation and regeneration, drives cell proliferation and promotes survival. We have previously demonstrated that neuropeptide pituitary adenylate…
2017 American Transplant Congress
ERK and HIF1 Play a Major Role in Hypothermic Protection Against Renal Ischemia-Reperfusion Injury.
K. Lee,¹ J. Jeong,² D. Choi,¹ K. Na,¹ H. Bae,¹ Y. Ham.¹
¹Chungnam National University, Nephrology, Daejeon, Korea; ²Chungnam National University, Department of Medical Science, Daejeon, Korea
Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
2016 American Transplant Congress
Calcineurin Inhibitor (CNI) Nephrotoxicity Is Mediated by Defective Amp-Activated Protein Kinase (AMPK) Activation.
A. Zmijewska, J. Chen, J. Zmijewski, R. Mannon.
Medicine, UAB, Birmingham, AL.
Background: CNIs are potent immunosuppressant therapies, but associated with nephrotoxicity manifested by interstitial fibrosis and progressive graft dysfunction. AMPK is a major sensor and regulator…
2015 American Transplant Congress
Engagement of the Vasopressin Receptor On Hepatocytes Protects Liver from Ischemia-Reperfusion Injury Via the WNT-β-Catenin-SGK1-FOXO Pathway
X. Liu,¹ T. Billiar,² R. Tao.¹
¹Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; ²Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
The synthetic vasopressin analogue, terlipressin, has been extensively used in the management of certain complications associated with end-stage liver diseases (ESLDs), however concerns have been…
2015 American Transplant Congress
Can MitoQ Improve Renal and Mitochondrial Function Following Cold Storage and Transplantation?
L. MacMillan-Crow,¹ N. Parajuli,¹ D. Borja-Cacho.
¹Pharmacology/Toxicology, Univ. of Arkansas for Medical Sciences, Little Rock, AR; ²Surgery, Univ. of Arkansas for Medical Sciences, Little Rock, AR.
The overall goal of this study is to further evaluate the effectiveness of a potential new therapy designed to minimize damage during cold preservation, increase…
2015 American Transplant Congress
Speed of Onset of Donor Brain Death Leads to Differences in Renal Function and Expression of Inflammatory and Oxidative Stress Markers in Rat Kidneys
D. Hoeksma,¹ R. Rebolledo,² M. Hottenrott,³ Y. Bodar,¹ H. Leuvenink.¹
¹Abdominal Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Faculty of Medicine, University of Chile, Santiago, Chile; ³Cardiothoracic Surgery, University Medical Center Groningen, Groningen, Netherlands.
IntroductionDonor brain death (BD) is an independent risk factor for primary and delayed renal graft function. Furthermore, the speed of onset of brain death, traumatic…