ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Oxidant stress"

  • 2020 American Transplant Congress

    Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury

    K. J. Dery, H. Hirao, K. Kadono, S. Kageyama, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski

    Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…
  • 2020 American Transplant Congress

    Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury

    M. Kawamura1, R. Imamura1, Y. Kobayashi2, A. Taniguchi1, S. Nakazawa1, T. Kato1, T. Abe1, H. Kobayashi2, N. Nonomura1

    1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan

    *Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
  • 2020 American Transplant Congress

    Cyclo(His-Pro) Prevents Against Renal Injury Through Activating Nrf2-Mediated Pathway

    J. Moon1, Y. Kim1, H. Jung2, J. Kim1, W. Ju3, H. Lee1, J. Lee4, C. Lee5, D. Kim1, Y. Kim1, S. Yang6

    1Seoul National University Hospital, Seoul, Korea, Republic of, 2R&D Center, NovMetaPharma Co., Ltd, Pohang, Gyeongbuk, Korea, Republic of, 3Seoul National University Biomedical Research Institute, Seoul, Korea, Republic of, 4Nephrology Clinic, National Cancer Center, Goyang, Korea, Republic of, 5Cheju Halla General Hospital, Jeju-do, Korea, Republic of, 6Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Cyclic(His-Pro) (CHP) is an endogenous cyclic dipeptide that has antioxidative, anti-inflammatory effect via Nuclear factor erythroid 2-related factor (Nrf2) pathway. Endogenous CHP is distributed…
  • 2020 American Transplant Congress

    The Negative Impact of Inherent Oxidative Stress in Marginal Lungs on Ex Vivo Lung Perfusion

    K. Noda1, B. J. Philips1, M. Velayutham2, T. Harano1, P. Reck dos Santos1, S. Shiva2, P. G. Sanchez1

    1Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, 2Department of Medicine, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Identifying good quality grafts within the donor pool, ex vivo lung perfusion (EVLP) opens another window to evaluate grafts initially declined with marginal quality…
  • 2020 American Transplant Congress

    Prophylactic Treatment with Antioxidant Nanoparticles Attenuate Ischemia/Reperfusion Injury in BALB/c Mice

    S. Yoon1, K. Lee1, W. Hwang1, S. Yun1, K. Yoon2

    1Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, 2Chemistry, Hannam University, Daejeon, Korea, Republic of

    *Purpose: Kidney is more susceptible to hypoxic damage than other organ because kidney tissue consumes most of oxygen to move various solute across membrane. Ischemia/reperfusion…
  • 2020 American Transplant Congress

    Human Antigen R (HuR): A New Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplantation

    K. J. Dery1, K. Nakamura2, K. Kadono1, H. Hirao1, S. Kageyama1, T. Ito1, H. Kojima1, F. Kaldas1, R. W. Busuttil1, J. W. Kupiec-Weglinski1

    1Department of Surgery, Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA, 2Surgery, Nishi-Kobe Medical Center, Hyogo, Japan

    *Purpose: Ischemia-reperfusion injury (IRI) represents a risk factor in liver transplantation (LT). We have shown that overexpression of heme oxygenase 1 (HO-1) mitigates hepatic IRI…
  • 2020 American Transplant Congress

    Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats

    H. Lin1, S. Dai2, W. Liu3, X. Lin2, B. Yu2, S. Chen3, S. Liu2, J. Tang2

    1Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, 2Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, 3Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China

    *Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
  • 2020 American Transplant Congress

    Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers

    I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
  • 2019 American Transplant Congress

    NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice

    D. Choi1, J. Hwang2, J. Jeong3, K. Lee1, K. Na1, Y. Ham1, J. Jeon1, H. Kim1, Y. Chang1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, 3Medical Science, Chungnam National University, Daejeon, Korea, Republic of

    *Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
  • 2019 American Transplant Congress

    Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK

    D. Choi1, J. Jeong2, K. Lee1, K. Na1, Y. Chang3, Y. Ham1, J. Jeon1, H. Kim1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Medical Science, Chungnam National University, Daejeon, Korea, Republic of, 3Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of

    *Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
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