Articles tagged "Oxidant stress"

2020 American Transplant Congress
Prophylactic Treatment with Antioxidant Nanoparticles Attenuate Ischemia/Reperfusion Injury in BALB/c Mice
S. Yoon¹, K. Lee¹, W. Hwang¹, S. Yun¹, K. Yoon²
¹Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, ²Chemistry, Hannam University, Daejeon, Korea, Republic of
*Purpose: Kidney is more susceptible to hypoxic damage than other organ because kidney tissue consumes most of oxygen to move various solute across membrane. Ischemia/reperfusion…
2020 American Transplant Congress
Human Antigen R (HuR): A New Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplantation
K. J. Dery¹, K. Nakamura², K. Kadono¹, H. Hirao¹, S. Kageyama¹, T. Ito¹, H. Kojima¹, F. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Department of Surgery, Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA, ²Surgery, Nishi-Kobe Medical Center, Hyogo, Japan
*Purpose: Ischemia-reperfusion injury (IRI) represents a risk factor in liver transplantation (LT). We have shown that overexpression of heme oxygenase 1 (HO-1) mitigates hepatic IRI…
2019 American Transplant Congress
NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice
D. Choi¹, J. Hwang², J. Jeong³, K. Lee¹, K. Na¹, Y. Ham¹, J. Jeon¹, H. Kim¹, Y. Chang¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, ³Medical Science, Chungnam National University, Daejeon, Korea, Republic of
*Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
2019 American Transplant Congress
Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK
D. Choi¹, J. Jeong², K. Lee¹, K. Na¹, Y. Chang³, Y. Ham¹, J. Jeon¹, H. Kim¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
2019 American Transplant Congress
Activation of Oxidative Stress-Adoptive Responses during Extended Ex Situ Heart Perfusion
S. Hatami, X. Qi, M. Buchko, C. W. White, S. Bozso, S. Himmat, J. Nagendran, D. H. Freed
Department of Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Cardiac function declines in a time-related fashion during ex situ heart perfusion (ESHP) regardless of ventricular load status. We have previously shown that the…
2019 American Transplant Congress
Effect of Renal Function on Asymmetric Dimethylarginine (ADMA) Homeostasis in Kidney Donors and Recipients
M. Y. Said¹, R. M. Douwes¹, M. van Londen¹, I. Minović¹, A. Frenay², M. H. de Borst¹, E. van den Berg¹, M. R. Heiner-Fokkema³, A. A. Kayacelebi⁴, A. Bollenbach⁴, H. van Goor⁵, G. J. Navis¹, D. Tsikas⁴, S. J. Bakker¹
¹Internal medicine, University Medical Center Groningen, Groningen, Netherlands, ²Gynecology and Obstetrics, Amsterdam University Medical Center, Amsterdam, Netherlands, ³Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, ⁴Inst. of Toxicology, Core Unit Proteomics, Hannover Medical School, Hannover, Germany, ⁵Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
*Purpose: ADMA is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Plasma ADMA (pADMA) is known as a strong cardiovascular risk…
2019 American Transplant Congress
Targeting Syk Signaling in Myeloid Cells Protects against Liver Fibrosis and Hepatocarcinogenesis
A. Torres-Hernandez, W. Wang, G. Miller
Surgery, NYU School of Medicine, New York, NY
*Purpose: The purpose of our study was to evaluate the mechanistic role of Spleen Tyrosine Kinase (SYK) signaling on the fibrosis - hepatocarcinogenesis axis and…
2018 American Transplant Congress
Assessment of Hepatic Ischemia-Reperfusion Injuries by NRF2-Dependent Transcriptional Activities of Bile Transporters in Rats
J. Kim,¹ A. Martin,¹ J. Yee,¹ L. Fojut,¹ A. Geurts,² K. Oshima,³ M. Zimmerman,¹ J. Hong.¹
¹Surgery, Medical College of Wisconsin, Milwaukee, WI; ²Physiology, Medical College of Wisconsin, Milwaukee, WI; ³Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: The effect of hepatic ischemia and reperfusion injury (IRI) on bile transporter (BT) gene expression and the role of Nrf2 in BT regulation during…
2018 American Transplant Congress
Neuropeptide PACAP Protects Hepatocyte against Liver Ischemia/Reperfusion Injury by Promoting Yes-Associated Protein (YAP) Function
Z. Xue, Y. Liu, C. Zhang, R. Busuttil, J. Kupiec-Weglinski, H. Ji.
Dept of Surgery, The DumontUCLA Transplant Center, Los Angeles, CA.
Background: Previously we have demonstrated that neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) suppressed local inflammation, and protected liver against IRI by innervating the liver and…
2018 American Transplant Congress
Dehydropeptidase-Iinhibitor Reduces Tacrolimus-Induced Kidney Injury by Anti-Oxidative and Anti-Apoptotic Effect
K. Luo,¹ S. Lim,¹ J. Il,¹ Y. Shin,¹ E. Ko,^1,2 B. Chung,^1,2 H. Hwang,^1,2 C. Yang.^1,2
¹Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; ²Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea.
Background:Cilastatin is an inhibitor of dehydropeptidase-I which enhances the antibacterial activity of imipenem.Dehydropeptidase I is associated with not only the metabolism of the enzyme but…