ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Oxidant stress"

  • 2020 American Transplant Congress

    Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats

    H. Lin1, S. Dai2, W. Liu3, X. Lin2, B. Yu2, S. Chen3, S. Liu2, J. Tang2

    1Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, 2Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, 3Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China

    *Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
  • 2020 American Transplant Congress

    Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers

    I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
  • 2019 American Transplant Congress

    Effect of Renal Function on Asymmetric Dimethylarginine (ADMA) Homeostasis in Kidney Donors and Recipients

    M. Y. Said1, R. M. Douwes1, M. van Londen1, I. Minović1, A. Frenay2, M. H. de Borst1, E. van den Berg1, M. R. Heiner-Fokkema3, A. A. Kayacelebi4, A. Bollenbach4, H. van Goor5, G. J. Navis1, D. Tsikas4, S. J. Bakker1

    1Internal medicine, University Medical Center Groningen, Groningen, Netherlands, 2Gynecology and Obstetrics, Amsterdam University Medical Center, Amsterdam, Netherlands, 3Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, 4Inst. of Toxicology, Core Unit Proteomics, Hannover Medical School, Hannover, Germany, 5Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands

    *Purpose: ADMA is a methylated form of arginine and an endogenous nitric oxide synthase inhibitor. Plasma ADMA (pADMA) is known as a strong cardiovascular risk…
  • 2019 American Transplant Congress

    Targeting Syk Signaling in Myeloid Cells Protects against Liver Fibrosis and Hepatocarcinogenesis

    A. Torres-Hernandez, W. Wang, G. Miller

    Surgery, NYU School of Medicine, New York, NY

    *Purpose: The purpose of our study was to evaluate the mechanistic role of Spleen Tyrosine Kinase (SYK) signaling on the fibrosis - hepatocarcinogenesis axis and…
  • 2019 American Transplant Congress

    NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice

    D. Choi1, J. Hwang2, J. Jeong3, K. Lee1, K. Na1, Y. Ham1, J. Jeon1, H. Kim1, Y. Chang1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, 3Medical Science, Chungnam National University, Daejeon, Korea, Republic of

    *Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
  • 2019 American Transplant Congress

    Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK

    D. Choi1, J. Jeong2, K. Lee1, K. Na1, Y. Chang3, Y. Ham1, J. Jeon1, H. Kim1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Medical Science, Chungnam National University, Daejeon, Korea, Republic of, 3Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of

    *Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…
  • 2019 American Transplant Congress

    Activation of Oxidative Stress-Adoptive Responses during Extended Ex Situ Heart Perfusion

    S. Hatami, X. Qi, M. Buchko, C. W. White, S. Bozso, S. Himmat, J. Nagendran, D. H. Freed

    Department of Surgery, University of Alberta, Edmonton, AB, Canada

    *Purpose: Cardiac function declines in a time-related fashion during ex situ heart perfusion (ESHP) regardless of ventricular load status. We have previously shown that the…
  • 2018 American Transplant Congress

    Assessment of Hepatic Ischemia-Reperfusion Injuries by NRF2-Dependent Transcriptional Activities of Bile Transporters in Rats

    J. Kim,1 A. Martin,1 J. Yee,1 L. Fojut,1 A. Geurts,2 K. Oshima,3 M. Zimmerman,1 J. Hong.1

    1Surgery, Medical College of Wisconsin, Milwaukee, WI; 2Physiology, Medical College of Wisconsin, Milwaukee, WI; 3Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

    Background: The effect of hepatic ischemia and reperfusion injury (IRI) on bile transporter (BT) gene expression and the role of Nrf2 in BT regulation during…
  • 2018 American Transplant Congress

    Neuropeptide PACAP Protects Hepatocyte against Liver Ischemia/Reperfusion Injury by Promoting Yes-Associated Protein (YAP) Function

    Z. Xue, Y. Liu, C. Zhang, R. Busuttil, J. Kupiec-Weglinski, H. Ji.

    Dept of Surgery, The DumontUCLA Transplant Center, Los Angeles, CA.

    Background: Previously we have demonstrated that neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) suppressed local inflammation, and protected liver against IRI by innervating the liver and…
  • 2018 American Transplant Congress

    Dehydropeptidase-Iinhibitor Reduces Tacrolimus-Induced Kidney Injury by Anti-Oxidative and Anti-Apoptotic Effect

    K. Luo,1 S. Lim,1 J. Il,1 Y. Shin,1 E. Ko,1,2 B. Chung,1,2 H. Hwang,1,2 C. Yang.1,2

    1Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea; 2Transplant Research Center, The Catholic University of Korea, Seoul, Republic of Korea.

    Background:Cilastatin is an inhibitor of dehydropeptidase-I which enhances the antibacterial activity of imipenem.Dehydropeptidase I is associated with not only the metabolism of the enzyme but…
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