ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Oxidant stress"

  • 2022 American Transplant Congress

    Allo-Sensitization is Increased in Liver Transplant Recipients Following Ischemia-Reperfusion Injury

    R. A. Sosa, A. Q. Terry, Y. Yin, B. V. Naini, F. M. Kaldas, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed

    UCLA, Los Angeles, CA

    *Purpose: Recipient sensitization to donor HLA antigens remains an important clinical problem in transplantation, leading to increased wait times to find a compatible donor and…
  • 2022 American Transplant Congress

    Final Report of the Use of α-Lipoic Acid in Liver Transplantation to Prevent Ischemia Reperfusion Injury

    P. C. Casciato1, N. Ambrosi2, F. Caro2, L. Oliveira1, F. Zalazar1, A. Garmendia1, M. Bonifacio1, M. Padilla1, J. Paladini1, J. Di Menno1, J. Pekjol1, E. de Santibañes1, M. de Santibañes1, G. Adrian1, C. Incardona1, E. Chuluyan2

    1Hospital Italiano, Buenos Aires, Argentina, 2CEFYBO, Buenos Aires, Argentina

    *Purpose: The ischemia and reperfusion injury contributs to grafts deterioration and adverse post-transplant outcomes. The aim of the present study was to evaluate the safety…
  • 2022 American Transplant Congress

    Mitochondrial Transplant as Novel Therapeutic Modality to Reduce Nonalcoholic Fatty Liver Disease

    M. Namwanje1, A. Stayton1, C. White1, C. Kuscu1, C. Kuscu1, J. Eason2, A. Bajwa1

    1Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, 2University of Tennessee/Methodist Transplant Institute, Memphis, TN

    *Purpose: Mitochondrial dysfunction in adipose tissue is one of the mechanisms contributing to obesity and its co-morbidities. Transfer of healthy mitochondria has proven successful in…
  • 2022 American Transplant Congress

    Effect of Dual Inhibition of DPP4 and SGLT2 on Tacrolimus-Induced Diabetes Mellitus and Nephrotoxicity in Rat Model

    E. Ko, Y. Shin, C. Seung, S. Lim, B. Chung, C. Yang

    Seoul St.Mary's Hospital, Seoul, Korea, Republic of

    *Purpose: Sodium/glucose co-transporter-2 inhibitor (SGLT2i) or dipeptidyl peptidase IV inhibitor (DPP4i) are popular anti-diabetic drugs in type II diabetes mellitus (DM), but their use in…
  • 2020 American Transplant Congress

    Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats

    H. Lin1, S. Dai2, W. Liu3, X. Lin2, B. Yu2, S. Chen3, S. Liu2, J. Tang2

    1Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, 2Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, 3Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China

    *Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
  • 2020 American Transplant Congress

    Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers

    I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
  • 2020 American Transplant Congress

    Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury

    K. J. Dery, H. Hirao, K. Kadono, S. Kageyama, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski

    Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…
  • 2020 American Transplant Congress

    Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury

    M. Kawamura1, R. Imamura1, Y. Kobayashi2, A. Taniguchi1, S. Nakazawa1, T. Kato1, T. Abe1, H. Kobayashi2, N. Nonomura1

    1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, 2The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan

    *Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
  • 2020 American Transplant Congress

    Cyclo(His-Pro) Prevents Against Renal Injury Through Activating Nrf2-Mediated Pathway

    J. Moon1, Y. Kim1, H. Jung2, J. Kim1, W. Ju3, H. Lee1, J. Lee4, C. Lee5, D. Kim1, Y. Kim1, S. Yang6

    1Seoul National University Hospital, Seoul, Korea, Republic of, 2R&D Center, NovMetaPharma Co., Ltd, Pohang, Gyeongbuk, Korea, Republic of, 3Seoul National University Biomedical Research Institute, Seoul, Korea, Republic of, 4Nephrology Clinic, National Cancer Center, Goyang, Korea, Republic of, 5Cheju Halla General Hospital, Jeju-do, Korea, Republic of, 6Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Cyclic(His-Pro) (CHP) is an endogenous cyclic dipeptide that has antioxidative, anti-inflammatory effect via Nuclear factor erythroid 2-related factor (Nrf2) pathway. Endogenous CHP is distributed…
  • 2020 American Transplant Congress

    The Negative Impact of Inherent Oxidative Stress in Marginal Lungs on Ex Vivo Lung Perfusion

    K. Noda1, B. J. Philips1, M. Velayutham2, T. Harano1, P. Reck dos Santos1, S. Shiva2, P. G. Sanchez1

    1Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, 2Department of Medicine, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Identifying good quality grafts within the donor pool, ex vivo lung perfusion (EVLP) opens another window to evaluate grafts initially declined with marginal quality…
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