Articles tagged "Oxidant stress"

2022 American Transplant Congress
Allo-Sensitization is Increased in Liver Transplant Recipients Following Ischemia-Reperfusion Injury
R. A. Sosa, A. Q. Terry, Y. Yin, B. V. Naini, F. M. Kaldas, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed
UCLA, Los Angeles, CA
*Purpose: Recipient sensitization to donor HLA antigens remains an important clinical problem in transplantation, leading to increased wait times to find a compatible donor and…
2022 American Transplant Congress
Final Report of the Use of α-Lipoic Acid in Liver Transplantation to Prevent Ischemia Reperfusion Injury
P. C. Casciato¹, N. Ambrosi², F. Caro², L. Oliveira¹, F. Zalazar¹, A. Garmendia¹, M. Bonifacio¹, M. Padilla¹, J. Paladini¹, J. Di Menno¹, J. Pekjol¹, E. de Santibañes¹, M. de Santibañes¹, G. Adrian¹, C. Incardona¹, E. Chuluyan²
¹Hospital Italiano, Buenos Aires, Argentina, ²CEFYBO, Buenos Aires, Argentina
*Purpose: The ischemia and reperfusion injury contributs to grafts deterioration and adverse post-transplant outcomes. The aim of the present study was to evaluate the safety…
2022 American Transplant Congress
Mitochondrial Transplant as Novel Therapeutic Modality to Reduce Nonalcoholic Fatty Liver Disease
M. Namwanje¹, A. Stayton¹, C. White¹, C. Kuscu¹, C. Kuscu¹, J. Eason², A. Bajwa¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Mitochondrial dysfunction in adipose tissue is one of the mechanisms contributing to obesity and its co-morbidities. Transfer of healthy mitochondria has proven successful in…
2022 American Transplant Congress
Effect of Dual Inhibition of DPP4 and SGLT2 on Tacrolimus-Induced Diabetes Mellitus and Nephrotoxicity in Rat Model
E. Ko, Y. Shin, C. Seung, S. Lim, B. Chung, C. Yang
Seoul St.Mary's Hospital, Seoul, Korea, Republic of
*Purpose: Sodium/glucose co-transporter-2 inhibitor (SGLT2i) or dipeptidyl peptidase IV inhibitor (DPP4i) are popular anti-diabetic drugs in type II diabetes mellitus (DM), but their use in…
2020 American Transplant Congress
Oxidative Stress Induces Cytoprotective Alternative Splicing in Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 in Mouse Liver Ischemia-Reperfusion Injury
K. J. Dery, H. Hirao, K. Kadono, S. Kageyama, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We have recently shown that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) serves as a checkpoint regulator in liver transplant (LT) ischemia-reperfusion injury (IRI);…
2020 American Transplant Congress
Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury
M. Kawamura¹, R. Imamura¹, Y. Kobayashi², A. Taniguchi¹, S. Nakazawa¹, T. Kato¹, T. Abe¹, H. Kobayashi², N. Nonomura¹
¹Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, ²The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan
*Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
2020 American Transplant Congress
Cyclo(His-Pro) Prevents Against Renal Injury Through Activating Nrf2-Mediated Pathway
J. Moon¹, Y. Kim¹, H. Jung², J. Kim¹, W. Ju³, H. Lee¹, J. Lee⁴, C. Lee⁵, D. Kim¹, Y. Kim¹, S. Yang⁶
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²R&D Center, NovMetaPharma Co., Ltd, Pohang, Gyeongbuk, Korea, Republic of, ³Seoul National University Biomedical Research Institute, Seoul, Korea, Republic of, ⁴Nephrology Clinic, National Cancer Center, Goyang, Korea, Republic of, ⁵Cheju Halla General Hospital, Jeju-do, Korea, Republic of, ⁶Kidney Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Cyclic(His-Pro) (CHP) is an endogenous cyclic dipeptide that has antioxidative, anti-inflammatory effect via Nuclear factor erythroid 2-related factor (Nrf2) pathway. Endogenous CHP is distributed…
2020 American Transplant Congress
The Negative Impact of Inherent Oxidative Stress in Marginal Lungs on Ex Vivo Lung Perfusion
K. Noda¹, B. J. Philips¹, M. Velayutham², T. Harano¹, P. Reck dos Santos¹, S. Shiva², P. G. Sanchez¹
¹Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, ²Department of Medicine, University of Pittsburgh, Pittsburgh, PA
*Purpose: Identifying good quality grafts within the donor pool, ex vivo lung perfusion (EVLP) opens another window to evaluate grafts initially declined with marginal quality…
2020 American Transplant Congress
Prophylactic Treatment with Antioxidant Nanoparticles Attenuate Ischemia/Reperfusion Injury in BALB/c Mice
S. Yoon¹, K. Lee¹, W. Hwang¹, S. Yun¹, K. Yoon²
¹Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, ²Chemistry, Hannam University, Daejeon, Korea, Republic of
*Purpose: Kidney is more susceptible to hypoxic damage than other organ because kidney tissue consumes most of oxygen to move various solute across membrane. Ischemia/reperfusion…
2020 American Transplant Congress
Human Antigen R (HuR): A New Regulator of Heme Oxygenase-1 Cytoprotection in Mouse and Human Liver Transplantation
K. J. Dery¹, K. Nakamura², K. Kadono¹, H. Hirao¹, S. Kageyama¹, T. Ito¹, H. Kojima¹, F. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Department of Surgery, Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA, ²Surgery, Nishi-Kobe Medical Center, Hyogo, Japan
*Purpose: Ischemia-reperfusion injury (IRI) represents a risk factor in liver transplantation (LT). We have shown that overexpression of heme oxygenase 1 (HO-1) mitigates hepatic IRI…