Articles tagged "Non-invasive diagnosis"

2019 American Transplant Congress
Utility of Gallium-67 Single Photon Emission Computed Tomography in the Evaluation of Left Ventricular Assist Device Infections
F. Parkar¹, A. Tlamsa², J. Nistico², V. A. Muggia², G. Y. Minamoto², U. Jorde³, D. J. Goldstein³, R. Moadel¹, Y. A. Puius²
¹Division of Nuclear Medicine, Montefiore Medical Center, Bronx, NY, ²Division of Infectious Diseases, Montefiore Medical Center, Bronx, NY, ³Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, Bronx, NY
*Purpose: We routinely use gallium-67 single photon emission computed tomography (67Ga-SPECT-CT) to determine the presence and extent of left ventricular assist device (LVAD) infections. The…
2019 American Transplant Congress
Identification of Rare Genetic Disorders in Kidney Transplantation Recipients with Un-Diagnosed Nephropathy through NGS Approach
G. Castellano, M. Giliberti, P. Pontrelli, M. Gigante, S. Diella, M. Accetturo, E. Stea, A. Mitrotti, L. Gesualdo
Emergency and Organ Transplantation, University of Bari, Bari, Italy
*Purpose: About 10% of end stage renal disease (ESRD) patients have no diagnosis of the primary kidney disease. Patients with unknown renal pathology can access…
2018 American Transplant Congress
The Efficacy of Laser Speckle Flowgraphy Device for Intraoperative Evaluation of Renal Blood Flow after Reperfusion
M. Muramatsu,¹ Y. Itabashi,¹ Y. Takahashi,² K. Sakurabayashi,¹ T. Mizutani,¹ Y. Hyodo,¹ Y. Hamasaki,² T. Kawamura,¹ K. Sakai,¹ S. Shishido.^1,2
¹Nephrology, Toho University Faculty of Medicine, Tokyo, Japan; ²Pediatric Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
Purpose:Laser speckle flowgraphy (LSFG) is a device to monitor cutaneous and ocular fundus blood flow. However, there is no report that the device was used…
2018 American Transplant Congress
mRNA Transcript Profiles of 14 Genes in Plasma Exosome Predict Risk for Antibody-Mediated Rejection (ABMR) of Renal Allografts
H. Zhang,¹ E. Huang,² C. Nast,³ J. Kahwaji,² A. Vo,² S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ³Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Previously we reported that mRNA transcript profiles of 4 genes (gp130, SH2D1B, TNFα and CCL4) in plasma exosome could predict the risk of ABMR,…
2018 American Transplant Congress
Diagnostic Accuracy of Non-Invasive Test of Hepatic Fibrosis in Liver Transplant Recipients
D. Galvez,¹ C. Bhati,¹ M. Siddiqui,² C. Schmoyer,² T. Arshad,² A. Sharma,¹ A. Cotterell,¹ K. Yadav,¹ T. Reichman,¹ M. Levy.¹
¹Department of Surgery, Virginia Commonwealth University Hospital, Richmond, VA; ²Department of Medicine, Virginia Commonwealth University Hospital, Richmond, VA.
Background & Aims: Hepatic fibrosis is an important predictor of liver- and non-liver related outcomes in patients with chronic liver disease (CLD) and liver transplantation…
2018 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish BK Virus Nephropathy from Acute Rejection in Kidney Transplant Patients with Graft Dysfunction
K. Keslar,¹ P. Gotwald,¹ W. Xu,² A. Zmijewska,³ J. Chen,³ K. Newell,⁴ P. Heeger,⁵ J. Bromberg,⁶ R. Mannon,³ R. Fairchild,¹ The CTOT Consortium.
¹Cleveland Clinic, Cleveland, OH; ²Nanostring Technologies, Seattle, WA; ³University of Alabama at Birmingham, Birmingham, AL; ⁴Emory University, Atlanta, GA; ⁵Icahn School of Medicine at Mt. Sinai, New York, NY; ⁶University of Maryland, Baltimore, MD.
Acute cellular rejection and BK virus nephropathy both cause deteriorating graft function that can lead to graft loss. Distinguishing the two conditions rapidly and accurately…
2018 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
J. Assaker,¹ A. Srivastava,¹ J. Hurley,² B. Al Doujailan,¹ S. Eskandari,¹ C. Coticchia,² M. Mohamed,¹ S. Bentink,² V. Tadigotla,² L. Riella,¹ A. Chandraker,¹ J. Skog,² J. Azzi.¹
¹Transplantation Renal Center, BWH and BCH, Boston; ²Exosome Diagnostic Inc., Cambridge.
Kidney transplant rejection leads to short and long-term adverse clinical outcomes. Serum creatinine is a suboptimal late biomarker for rejection. Exosomes are nanometer-sized vesicles released…
2018 American Transplant Congress
Acute Tubular and Glomerular Kidney Injury Markers Reflect Ischemia-Reperfusion and Rejection
Y. Shim, R. Fan, N. Dvorina, W. Baldwin.
Immunology, Cleveland Clinic, Cleveland, OH.
Reliable markers of early acute injury following renal transplantation would enable timely therapeutic interventions. Standard serum creatinine and blood urea nitrogen measurements increase only after…
2018 American Transplant Congress
Non-Invasive Imaging Modalities for Immune Monitoring of Vascularized Composite Allografts Using a Translational Large Animal Model
J. Etra,¹ K. Cilwa,² G. Furtmueller,¹ A. Leto Barone,¹ K. Kolegraff,¹ E. Elster,¹ W. Lee,¹ G. Brandacher.¹
¹Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Naval Medical Research Center, Silver Springs, MD; ³Department of Surgery, Uniformed Services, University of Health Sciences and Walter Reed National Military Medical Center, Bethesda, MD.
PurposeImmunological complications and skin rejection remains an obstacle in broadening the applicability of vascularized composite allotransplantation (VCA). Currently, diagnosis of rejection relies on skin biopsies…
2018 American Transplant Congress
Absolute Quantification of Plasma Graft-Derived Cell-Free DNA for Diagnosis of Kidney Transplant Rejection
J. Whitlam,¹ L. Ling,² F. Ierino,³ D. Bruno,² H. Slater,² D. Power.¹
¹Austin Health, Heidelberg, Victoria, Australia; ²Murdoch Childrens Research Institute, Parkville, Victoria, Australia; ³St Vincent's Health, Fitzroy, Victoria, Australia.
Aim: To study the performance of droplet digital PCR absolute measurement of graft-derived cell-free DNA (gdcfDNA) for the diagnosis of kidney allograft rejection.Methods: Homozygous deletion…