Articles tagged "Non-invasive diagnosis"

2019 American Transplant Congress
Utility of Gallium-67 Single Photon Emission Computed Tomography in the Evaluation of Left Ventricular Assist Device Infections
F. Parkar¹, A. Tlamsa², J. Nistico², V. A. Muggia², G. Y. Minamoto², U. Jorde³, D. J. Goldstein³, R. Moadel¹, Y. A. Puius²
¹Division of Nuclear Medicine, Montefiore Medical Center, Bronx, NY, ²Division of Infectious Diseases, Montefiore Medical Center, Bronx, NY, ³Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, Bronx, NY
*Purpose: We routinely use gallium-67 single photon emission computed tomography (67Ga-SPECT-CT) to determine the presence and extent of left ventricular assist device (LVAD) infections. The…
2019 American Transplant Congress
Identification of Rare Genetic Disorders in Kidney Transplantation Recipients with Un-Diagnosed Nephropathy through NGS Approach
G. Castellano, M. Giliberti, P. Pontrelli, M. Gigante, S. Diella, M. Accetturo, E. Stea, A. Mitrotti, L. Gesualdo
Emergency and Organ Transplantation, University of Bari, Bari, Italy
*Purpose: About 10% of end stage renal disease (ESRD) patients have no diagnosis of the primary kidney disease. Patients with unknown renal pathology can access…
2018 American Transplant Congress
Absolute Quantification of Plasma Graft-Derived Cell-Free DNA for Diagnosis of Kidney Transplant Rejection
J. Whitlam,¹ L. Ling,² F. Ierino,³ D. Bruno,² H. Slater,² D. Power.¹
¹Austin Health, Heidelberg, Victoria, Australia; ²Murdoch Childrens Research Institute, Parkville, Victoria, Australia; ³St Vincent's Health, Fitzroy, Victoria, Australia.
Aim: To study the performance of droplet digital PCR absolute measurement of graft-derived cell-free DNA (gdcfDNA) for the diagnosis of kidney allograft rejection.Methods: Homozygous deletion…
2018 American Transplant Congress
Noninvasive Detection of Infection and Rejection in Renal Transplant Patients
Y. Zhou,¹ Y. Cheng,¹ T. Chiang,² G. Yang,² X. Li,² F. Zeng,² X. Wang,¹ J. Ge,² X. Hu,² H. Shi,¹ T. Wang,² L. Liu.³
¹Laboratory of Transplant Genomics, Jiangsu University Institute of Life Science, ZhenJiang, JingSu, China; ²Reasearch and Development Dpartment, SuZhou RRGene.Co.Ltd., SuZhou, JiangSu, China; ³Department of Urological Organ Transplantation, The Second XiangYa Hospital of Center South University, ChangSha, Hunan, China.
About 35% of patients would suffer actue rejection or infectionin in two years after reanl trandplantation.Cell-free DNA (cfDNA) is a new biomarker to evluate health…
2018 American Transplant Congress
Kidney Transplantation is Associated with Decreasing Native T1 Time: A Cardiac Magnetic Resonance Study
M. Contti,¹ L. de Andrade,¹ H. Nga,¹ M. Valiatti,¹ H. Takase,¹ A. Bravin,¹ A. Mauricio,² M. Barbosa.³
¹Internal Medicine, Botucatu Medical School, Botucatu, Sao Paulo, Brazil; ²Radiology, Heart Institute of the Clinics Hospital at the Faculty of Medicine, University of São Paulo, São Paulo, Brazil; ³Radiology, Centro Avançado de Radiologia e Diagnóstico por Imagem, Presidente Prudente, Sao Paulo, Brazil.
Patients with stage 5 chronic kidney disease (CKD) have high rate of cardiovascular death. Kidney transplantantion, on the other hand, is associated with lower cardiovascular…
2018 American Transplant Congress
Renal Allograft Cortical Perfusion Quantification by 3D-Arterial Spin Labeling Could Be Used to Identify Subclinical Antibody-Mediated Rejection
W. Wang,¹ J. Wen,² F. Xu,² Y. Yu,³ L. Zhang,³ Z. Liu.²
¹Nanjing Medical University, Jinling School of Medicine, Nanjing, China; ²Jinling Hospital, Nanjing University School of Medicine, National Clinical Research Center of Kidney Diseases, Nanjing, China; ³Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Background: Antibody-mediated rejection (AMR) is now the most principal post-surgical complication complicating allograft long-term survival. Therefore, its early detection before serum creatinine rises/estimated glomerular filtration…
2018 American Transplant Congress
The Efficacy of Laser Speckle Flowgraphy Device for Intraoperative Evaluation of Renal Blood Flow after Reperfusion
M. Muramatsu,¹ Y. Itabashi,¹ Y. Takahashi,² K. Sakurabayashi,¹ T. Mizutani,¹ Y. Hyodo,¹ Y. Hamasaki,² T. Kawamura,¹ K. Sakai,¹ S. Shishido.^1,2
¹Nephrology, Toho University Faculty of Medicine, Tokyo, Japan; ²Pediatric Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
Purpose:Laser speckle flowgraphy (LSFG) is a device to monitor cutaneous and ocular fundus blood flow. However, there is no report that the device was used…
2018 American Transplant Congress
mRNA Transcript Profiles of 14 Genes in Plasma Exosome Predict Risk for Antibody-Mediated Rejection (ABMR) of Renal Allografts
H. Zhang,¹ E. Huang,² C. Nast,³ J. Kahwaji,² A. Vo,² S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ³Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Previously we reported that mRNA transcript profiles of 4 genes (gp130, SH2D1B, TNFα and CCL4) in plasma exosome could predict the risk of ABMR,…
2018 American Transplant Congress
Diagnostic Accuracy of Non-Invasive Test of Hepatic Fibrosis in Liver Transplant Recipients
D. Galvez,¹ C. Bhati,¹ M. Siddiqui,² C. Schmoyer,² T. Arshad,² A. Sharma,¹ A. Cotterell,¹ K. Yadav,¹ T. Reichman,¹ M. Levy.¹
¹Department of Surgery, Virginia Commonwealth University Hospital, Richmond, VA; ²Department of Medicine, Virginia Commonwealth University Hospital, Richmond, VA.
Background & Aims: Hepatic fibrosis is an important predictor of liver- and non-liver related outcomes in patients with chronic liver disease (CLD) and liver transplantation…
2018 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish BK Virus Nephropathy from Acute Rejection in Kidney Transplant Patients with Graft Dysfunction
K. Keslar,¹ P. Gotwald,¹ W. Xu,² A. Zmijewska,³ J. Chen,³ K. Newell,⁴ P. Heeger,⁵ J. Bromberg,⁶ R. Mannon,³ R. Fairchild,¹ The CTOT Consortium.
¹Cleveland Clinic, Cleveland, OH; ²Nanostring Technologies, Seattle, WA; ³University of Alabama at Birmingham, Birmingham, AL; ⁴Emory University, Atlanta, GA; ⁵Icahn School of Medicine at Mt. Sinai, New York, NY; ⁶University of Maryland, Baltimore, MD.
Acute cellular rejection and BK virus nephropathy both cause deteriorating graft function that can lead to graft loss. Distinguishing the two conditions rapidly and accurately…