Articles tagged "Non-invasive diagnosis"

2020 American Transplant Congress
Calibration of Donor-Derived Cell-Free DNA Criteria for Rejection with Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, L. Kamal¹, A. King¹, L. Kang¹, M. Levy¹, S. Bobba¹, D. Massey¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Traditional microscopic histopathologic assessment (HDx) can be prone to error due to inter-observer variability as well as the non-specificity of some histologic lesions. Donor-derived…
2020 American Transplant Congress
Urine Donor Derived Cell Free DNA Aids in the Diagnosis of BK Polyomavirus Nephropathy in Kidney Transplant Recipients with BK Viruria
G. Huang¹, X. Chen¹, W. Chen¹, P. Chen¹, T. Jiang², C. Wang¹, L. Chen¹
¹The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²AlloDx Biotech Co., Ltd, Suzhou, China
*Purpose: BK polyomavirus nephropathy (BKVN) are important cause of dysfunction and failure of renal transplants, which is similar to T cell mediated rejection (TCMR) in…
2019 American Transplant Congress
Alteration of Myocardial Velocities and T1 Times in Patients with Acute Cellular Rejection during First Year Post Heart Transplant
R. Sarnari, A. Ruh, M. Abbasi, J. Blaisdell, R. Dolan, J. Wilcox, S. Khan, E. Vorovich, J. Rich, A. Anderson, C. Yancy, J. Carr, M. Markl, K. Ghafourian
Northwestern University, Chicago, IL
*Purpose: We hypothesize that acute cellular rejection (ACR) episodes during the first year post heart transplant (HTx) may lead to structural and functional alterations of…
2019 American Transplant Congress
Utility of Gallium-67 Single Photon Emission Computed Tomography in the Evaluation of Left Ventricular Assist Device Infections
F. Parkar¹, A. Tlamsa², J. Nistico², V. A. Muggia², G. Y. Minamoto², U. Jorde³, D. J. Goldstein³, R. Moadel¹, Y. A. Puius²
¹Division of Nuclear Medicine, Montefiore Medical Center, Bronx, NY, ²Division of Infectious Diseases, Montefiore Medical Center, Bronx, NY, ³Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, Bronx, NY
*Purpose: We routinely use gallium-67 single photon emission computed tomography (67Ga-SPECT-CT) to determine the presence and extent of left ventricular assist device (LVAD) infections. The…
2019 American Transplant Congress
Identification of Rare Genetic Disorders in Kidney Transplantation Recipients with Un-Diagnosed Nephropathy through NGS Approach
G. Castellano, M. Giliberti, P. Pontrelli, M. Gigante, S. Diella, M. Accetturo, E. Stea, A. Mitrotti, L. Gesualdo
Emergency and Organ Transplantation, University of Bari, Bari, Italy
*Purpose: About 10% of end stage renal disease (ESRD) patients have no diagnosis of the primary kidney disease. Patients with unknown renal pathology can access…
2019 American Transplant Congress
An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation
E. Van Loon¹, S. Gazut², S. Yazdani¹, E. Lerut¹, H. de Loor¹, M. Coemans¹, L. Noël³, L. Thorrez¹, L. Van Lommel¹, F. Schuit¹, D. Lambrechts¹, T. Van Brussel¹, B. Sprangers¹, D. Kuypers¹, M. Essig⁴, W. Gwinner⁵, D. Anglicheau⁶, P. Marquet⁷, M. Naesens¹
¹Catholic University Leuven, Leuven, Belgium, ²CEA, Gif-sur-Yvette, France, ³Necker-Enfants Malades Institute, Paris, France, ⁴CHU Limoges, Limoges, France, ⁵Hannover Medical School, Hannover, Germany, ⁶Paris Descartes, Sorbonne Paris Cité University, Paris, France, ⁷RTRS Centaure, Necker Hospital, Paris, France
*Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
2019 American Transplant Congress
One Study: A Consortium Model of Clinical Trials Optimized for Comparing New Immune Therapies via Centralized Immune Monitoring
B. Sawitzki¹, S. Schlickeiser¹, M. Streitz¹, K. Jürchott¹, J. Hutchinson², E. Geissler², P. Investigators³
¹Charite Universitätsmedizin, Berlin, Germany, ²University of Regensburg, Regensburg, Germany, ³ONE Study Consortium, EU, Germany
*Purpose: Immune regulatory cell subpopulations can potentially control immune responses to allow immunosuppression (IS) drug minimization. In the ONE Study, an EU FP7-funded research group…
2019 American Transplant Congress
Bronchoalveolar Lavage Biomarkers Predict Lung Transplant Survival
A. Zarinsefat¹, J. Y. Yang², R. Sarwal¹, J. Liberto¹, D. Watson³, S. Verleden⁴, M. Sarwal¹
¹UC San Francisco, San Francisco, CA, ²Johns Hopkin, Baltimore, MD, ³Kit Bio, Los Altos, CA, ⁴KU Leuven, Leuven, Belgium
*Purpose: In lung transplants (LTx), chronic rejection remains a major cause of morbidity and mortality following transplantation, mainly from chronic lung allograft dysfunction (CLAD). Two…
2019 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish T Cell Mediated Acute Rejection from BK Virus Nephropathy in Kidney Transplant Patients
K. S. Keslar¹, W. Xu², A. A. Zmijewska³, K. A. Newell⁴, J. J. Friedewald⁵, M. I. Abecassis⁵, P. S. Heeger⁶, J. S. Bromberg⁷, R. B. Mannon³, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Nanostring Technologies, Seattle, WA, ³Univ. Alabama Birmingham, Birmingham, AL, ⁴Emory Univ., Atlanta, GA, ⁵Northwestern Univ., Chicago, IL, ⁶Icahn School of Med., New York, NY, ⁷Univ. Maryland, Baltimore, MD
*Purpose: There is a need to develop non-invasive approaches to detect ongoing kidney graft injury and distinguish immune from non-immune inflammation to guide therapy. Ideally…
2019 American Transplant Congress
Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, P. Halloran², L. Kamal¹, A. King¹, P. Kimball¹, M. Levy¹, C. Bhati¹, D. Massey¹, G. Gupta¹
¹VCU Medical Center, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Circulating donor-derived cell free DNA (cfDNA; Allosure, CareDx, USA), a non-invasive test that could detect rejection in kidney allografts was validated using histologic diagnoses(HDx).…

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