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American Transplant Congress abstracts

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Articles tagged "Non-invasive diagnosis"

  • 2020 American Transplant Congress

    Single Center Experience in Using Donor-Derived Cell-Free DNA in Kidney Transplant

    P. Homkrailas1, S. Lee2, B. Kandagedon1, G. Danovitch1, S. Bunnapradist1

    1Medicine, Division of Nephrology, Kidney and Pancreas Transplant Programs, UCLA, Los Angeles, CA, 2Department of Pharmacy, UCLA, Los Angeles, CA

    *Purpose: While the gold standard for diagnosing allograft rejection in kidney transplant recipients (KTX) continues to be histopathologic evaluation, it has been well recognized that…
  • 2020 American Transplant Congress

    Urinary CXCL10: From Diagnosis to Prediction of BK Viremia in Kidney Transplantation

    C. Tinel1, A. Vermorel1, D. Picciotto1, L. Morin1, C. Legendre1, M. Rabant2, D. Anglicheau1

    1Kidney Transplantation, Inserm U1151, Necker Hospital, Paris, France, 2Pathology, Necker Hospital, Paris, France

    *Purpose: Urinary CXCL10 (uCXCL10) has proved to be a useful tool for the non-invasive diagnosis of acute rejection in kidney transplant recipients (KTRs). Upon development,…
  • 2019 American Transplant Congress

    Unique Gene Expression Signatures in Urine Distinguish T Cell Mediated Acute Rejection from BK Virus Nephropathy in Kidney Transplant Patients

    K. S. Keslar1, W. Xu2, A. A. Zmijewska3, K. A. Newell4, J. J. Friedewald5, M. I. Abecassis5, P. S. Heeger6, J. S. Bromberg7, R. B. Mannon3, R. L. Fairchild1

    1Cleveland Clinic, Cleveland, OH, 2Nanostring Technologies, Seattle, WA, 3Univ. Alabama Birmingham, Birmingham, AL, 4Emory Univ., Atlanta, GA, 5Northwestern Univ., Chicago, IL, 6Icahn School of Med., New York, NY, 7Univ. Maryland, Baltimore, MD

    *Purpose: There is a need to develop non-invasive approaches to detect ongoing kidney graft injury and distinguish immune from non-immune inflammation to guide therapy. Ideally…
  • 2019 American Transplant Congress

    Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of Kidney Transplant Biopsies

    I. Moinuddin1, D. Kumar1, P. Halloran2, L. Kamal1, A. King1, P. Kimball1, M. Levy1, C. Bhati1, D. Massey1, G. Gupta1

    1VCU Medical Center, Richmond, VA, 2Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Circulating donor-derived cell free DNA (cfDNA; Allosure, CareDx, USA), a non-invasive test that could detect rejection in kidney allografts was validated using histologic diagnoses(HDx).…
  • 2019 American Transplant Congress

    Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients

    J. Seo1, Y. Lee1, S. Jung1, Y. Kim1, J. Moon1, K. Jeong1, C. Kim2, J. Park3, B. Chung4, Y. Kim5, S. Lee1

    1Nephrology, Kyung Hee University College of Medicine, Seoul, Korea, Republic of, 2Nephrology, Kyungpook National University College of Medicine, Daegu, Korea, Republic of, 3Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, 4Nephrology, The St. Mary’s Hospital of Catholic University of Korea, Seoul, Korea, Republic of, 5Nephrology, Inje University College of Medicine, Busan, Korea, Republic of

    *Purpose: Acute rejection (AR) is the main obstacle to the graft survival after kidney transplantation. Urinary exosome is a promising source of biomarker for various…
  • 2019 American Transplant Congress

    miRNA Signatures as Prediction Tool for DSA Development and Rejection

    M. Hamdorf1, L. M. Rebellato2, K. P. Briley2, M. J. Everly1

    1Terasaki Research Institute, Los Angeles, CA, 2East Carolina University, Greenville, NC

    *Purpose: Early and convenient diagnosis is urgently needed for acute and chronic transplant rejection due to its high risk of the loss of the transplant.…
  • 2019 American Transplant Congress

    Alteration of Myocardial Velocities and T1 Times in Patients with Acute Cellular Rejection during First Year Post Heart Transplant

    R. Sarnari, A. Ruh, M. Abbasi, J. Blaisdell, R. Dolan, J. Wilcox, S. Khan, E. Vorovich, J. Rich, A. Anderson, C. Yancy, J. Carr, M. Markl, K. Ghafourian

    Northwestern University, Chicago, IL

    *Purpose: We hypothesize that acute cellular rejection (ACR) episodes during the first year post heart transplant (HTx) may lead to structural and functional alterations of…
  • 2019 American Transplant Congress

    Utility of Gallium-67 Single Photon Emission Computed Tomography in the Evaluation of Left Ventricular Assist Device Infections

    F. Parkar1, A. Tlamsa2, J. Nistico2, V. A. Muggia2, G. Y. Minamoto2, U. Jorde3, D. J. Goldstein3, R. Moadel1, Y. A. Puius2

    1Division of Nuclear Medicine, Montefiore Medical Center, Bronx, NY, 2Division of Infectious Diseases, Montefiore Medical Center, Bronx, NY, 3Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, Bronx, NY

    *Purpose: We routinely use gallium-67 single photon emission computed tomography (67Ga-SPECT-CT) to determine the presence and extent of left ventricular assist device (LVAD) infections. The…
  • 2019 American Transplant Congress

    Identification of Rare Genetic Disorders in Kidney Transplantation Recipients with Un-Diagnosed Nephropathy through NGS Approach

    G. Castellano, M. Giliberti, P. Pontrelli, M. Gigante, S. Diella, M. Accetturo, E. Stea, A. Mitrotti, L. Gesualdo

    Emergency and Organ Transplantation, University of Bari, Bari, Italy

    *Purpose: About 10% of end stage renal disease (ESRD) patients have no diagnosis of the primary kidney disease. Patients with unknown renal pathology can access…
  • 2019 American Transplant Congress

    An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation

    E. Van Loon1, S. Gazut2, S. Yazdani1, E. Lerut1, H. de Loor1, M. Coemans1, L. Noël3, L. Thorrez1, L. Van Lommel1, F. Schuit1, D. Lambrechts1, T. Van Brussel1, B. Sprangers1, D. Kuypers1, M. Essig4, W. Gwinner5, D. Anglicheau6, P. Marquet7, M. Naesens1

    1Catholic University Leuven, Leuven, Belgium, 2CEA, Gif-sur-Yvette, France, 3Necker-Enfants Malades Institute, Paris, France, 4CHU Limoges, Limoges, France, 5Hannover Medical School, Hannover, Germany, 6Paris Descartes, Sorbonne Paris Cité University, Paris, France, 7RTRS Centaure, Necker Hospital, Paris, France

    *Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
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