Articles tagged "Non-invasive diagnosis"

2020 American Transplant Congress
An Optimized Integrative Model Using Urinary Chemokines for Noninvasive Diagnosis of Acute Allograft Rejection
C. Tinel¹, A. Devresse¹, A. Vermorel¹, D. Marx², S. Caillard², C. Legendre¹, M. Rabant³, D. Anglicheau¹
¹Nephrology and Kidney Transplantation, Inserm U1151, Necker Hospital, Paris, France, ²Nephrology and Kidney Transplantation, Strasbourg University Hospital, Strasbourg, France, ³Pathology, Necker Hospital, Paris, France
*Purpose: The aim of this study was to optimize the performance of urinary chemokines C-X-C motif ligand (CXCL) 9 and CXCL10 as noninvasive diagnostic markers…
2020 American Transplant Congress
Noninvasive Detection of Subclinical Rejection in Urine RNA
K. S. Keslar¹, D. Margeta¹, J. J. Friedewald², M. Abecassis², R. B. Mannon³, P. S. Heeger⁴, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Northwestern University, Chicago, IL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Icahn School of Medicine, New York, NY
*Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…
2019 American Transplant Congress
An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation
E. Van Loon¹, S. Gazut², S. Yazdani¹, E. Lerut¹, H. de Loor¹, M. Coemans¹, L. Noël³, L. Thorrez¹, L. Van Lommel¹, F. Schuit¹, D. Lambrechts¹, T. Van Brussel¹, B. Sprangers¹, D. Kuypers¹, M. Essig⁴, W. Gwinner⁵, D. Anglicheau⁶, P. Marquet⁷, M. Naesens¹
¹Catholic University Leuven, Leuven, Belgium, ²CEA, Gif-sur-Yvette, France, ³Necker-Enfants Malades Institute, Paris, France, ⁴CHU Limoges, Limoges, France, ⁵Hannover Medical School, Hannover, Germany, ⁶Paris Descartes, Sorbonne Paris Cité University, Paris, France, ⁷RTRS Centaure, Necker Hospital, Paris, France
*Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
2019 American Transplant Congress
One Study: A Consortium Model of Clinical Trials Optimized for Comparing New Immune Therapies via Centralized Immune Monitoring
B. Sawitzki¹, S. Schlickeiser¹, M. Streitz¹, K. Jürchott¹, J. Hutchinson², E. Geissler², P. Investigators³
¹Charite Universitätsmedizin, Berlin, Germany, ²University of Regensburg, Regensburg, Germany, ³ONE Study Consortium, EU, Germany
*Purpose: Immune regulatory cell subpopulations can potentially control immune responses to allow immunosuppression (IS) drug minimization. In the ONE Study, an EU FP7-funded research group…
2019 American Transplant Congress
Bronchoalveolar Lavage Biomarkers Predict Lung Transplant Survival
A. Zarinsefat¹, J. Y. Yang², R. Sarwal¹, J. Liberto¹, D. Watson³, S. Verleden⁴, M. Sarwal¹
¹UC San Francisco, San Francisco, CA, ²Johns Hopkin, Baltimore, MD, ³Kit Bio, Los Altos, CA, ⁴KU Leuven, Leuven, Belgium
*Purpose: In lung transplants (LTx), chronic rejection remains a major cause of morbidity and mortality following transplantation, mainly from chronic lung allograft dysfunction (CLAD). Two…
2019 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish T Cell Mediated Acute Rejection from BK Virus Nephropathy in Kidney Transplant Patients
K. S. Keslar¹, W. Xu², A. A. Zmijewska³, K. A. Newell⁴, J. J. Friedewald⁵, M. I. Abecassis⁵, P. S. Heeger⁶, J. S. Bromberg⁷, R. B. Mannon³, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Nanostring Technologies, Seattle, WA, ³Univ. Alabama Birmingham, Birmingham, AL, ⁴Emory Univ., Atlanta, GA, ⁵Northwestern Univ., Chicago, IL, ⁶Icahn School of Med., New York, NY, ⁷Univ. Maryland, Baltimore, MD
*Purpose: There is a need to develop non-invasive approaches to detect ongoing kidney graft injury and distinguish immune from non-immune inflammation to guide therapy. Ideally…
2019 American Transplant Congress
Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, P. Halloran², L. Kamal¹, A. King¹, P. Kimball¹, M. Levy¹, C. Bhati¹, D. Massey¹, G. Gupta¹
¹VCU Medical Center, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Circulating donor-derived cell free DNA (cfDNA; Allosure, CareDx, USA), a non-invasive test that could detect rejection in kidney allografts was validated using histologic diagnoses(HDx).…
2019 American Transplant Congress
Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients
J. Seo¹, Y. Lee¹, S. Jung¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Nephrology, Kyung Hee University College of Medicine, Seoul, Korea, Republic of, ²Nephrology, Kyungpook National University College of Medicine, Daegu, Korea, Republic of, ³Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ⁴Nephrology, The St. Mary’s Hospital of Catholic University of Korea, Seoul, Korea, Republic of, ⁵Nephrology, Inje University College of Medicine, Busan, Korea, Republic of
*Purpose: Acute rejection (AR) is the main obstacle to the graft survival after kidney transplantation. Urinary exosome is a promising source of biomarker for various…
2019 American Transplant Congress
miRNA Signatures as Prediction Tool for DSA Development and Rejection
M. Hamdorf¹, L. M. Rebellato², K. P. Briley², M. J. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC
*Purpose: Early and convenient diagnosis is urgently needed for acute and chronic transplant rejection due to its high risk of the loss of the transplant.…
2019 American Transplant Congress
Alteration of Myocardial Velocities and T1 Times in Patients with Acute Cellular Rejection during First Year Post Heart Transplant
R. Sarnari, A. Ruh, M. Abbasi, J. Blaisdell, R. Dolan, J. Wilcox, S. Khan, E. Vorovich, J. Rich, A. Anderson, C. Yancy, J. Carr, M. Markl, K. Ghafourian
Northwestern University, Chicago, IL
*Purpose: We hypothesize that acute cellular rejection (ACR) episodes during the first year post heart transplant (HTx) may lead to structural and functional alterations of…

« Previous Page
1
…
4
5
6
7
8
…
10
Next Page »