Articles tagged "Multicenter studies"

2019 American Transplant Congress
Fifteen Year Outcomes in the Astellas Double Blind Randomized Controlled Trial (RCT) Comparing Early Corticosteroid Withdrawal (CSWD) and Long-Term Corticosteroid Therapy Continuation (CCS) in Kidney Transplantation
E. Woodle¹, S. Clark², D. Stewart³, M. First⁴, R. Alloway⁵, J. Gill⁶, .. Split Rock Group⁷
¹Transplant Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, ²Providence Health Care, Vancouver, BC, Canada, ³UNOS, Richmond, VA, ⁴Transplant Genomics Inc. and Comprehensive Transplant Center, Northwestern University, Evanston, IL, ⁵University of Cincinnati College of Medicine, Cincinnati, OH, ⁶University of British Columbia, Vancouver, BC, Canada, ⁷Yale University, New Haven, CT
*Purpose: To evaluate long-term outcomes among participants in the original multi-center RCT initiated in 1999 (Woodle et al, Annals of Surgery, 2008), and to demonstrate…
2019 American Transplant Congress
Evaluating Potentially Inappropriate Prescribing in Older Kidney Transplant Recipients
L. DeVietro¹, B. Richardson², E. A. Cohen³, A. H. Toledo⁴, E. Marin⁵, K. R. Szempruch⁶
¹University of St. Joseph School of Pharmacy, Hartford, CT, ²University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, ³Pharmacy, Yale New Haven Hospital, New Haven, CT, ⁴Surgery-Transplant, University of North Carolina Medical Center, Chapel Hill, NC, ⁵Nephrology, Yale New Haven Hospital, New Haven, CT, ⁶Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC
*Purpose: While the Beers criteria (BC) and STOPP criteria (SC) have been validated in several patient populations to reduce medication use leading to adverse drug…
2019 American Transplant Congress
External Validation of the DCD-N Score and a Linear Prediction Model to Identify Potential Candidates for Donation after Circulatory Death: A Nation-Wide Cohort Study
M. F. Nijhoff¹, R. A. Pol¹, M. Volbeda¹, A. M. Kotsopoulos², J. P. Sonneveld³, J. van Dongen⁴, W. F. Abdo⁵, V. Silderhuis⁶, C. Moers¹
¹Surgery – Organ Donation and Transplantation, University Medical Center Groningen, Groningen, Netherlands, ²Department of Intensive Care Unit (ICU), Elisabeth Twee Steden Hospital, Tilburg, Netherlands, ³Department of ICU, Isala, Zwolle, Netherlands, ⁴Department of ICU, Catharina hospital, Eindhoven, Netherlands, ⁵Department of ICU, Radboud University Medical Center, Nijmegen, Netherlands, ⁶Department of ICU, Medisch Spectrum Twente, Enschede, Netherlands
*Purpose: Donation after circulatory death (DCD) is most often a controlled procedure after planned withdrawal of life-sustaining treatment (WLST) at an intensive care unit. In…
2019 American Transplant Congress
Kidney Transplant Outcomes in Recipients with Physical Impairments
A. G. Thomas¹, J. Ruck², N. Chu², D. Agoons², A. Shaffer², C. Haugen², H. Ying², B. Swenor², S. Norman³, J. Garonzik-Wang², D. Segev², M. McAdams-DeMarco²
¹Epidemiology, UNC Chapel Hill, Chapel Hill, NC, ²Johns Hopkins University, Baltimore, MD, ³University of Michigan, Ann Arbor, MI
*Purpose: Disability in general has been associated with poor outcomes in KT recipients. However, disability can be derived from various components, specifically visual, hearing, physical,…
2019 American Transplant Congress
Using a Commercially Available Assay That Measures Cytomegalovirus-Specific CD4+ and CD8+ T-cell Immunity to Predict Clinically Significant Cytomegalovirus Events in Solid Organ Transplant Recipients
R. Rogers¹, K. Saharia², A. Chandorkar², Z. Weiss³, D. Farmakiotis¹
¹Infectious Diseases, Brown University, Providence, RI, ²Infectious Diseases, University of Maryland, Baltimore, MD, ³Internal Medicine, Brown University, Providence, RI
*Purpose: To assess the diagnostic performance and clinical utility of the Viracor CMV T-cell Immunity Panel (CMV-TCIP), which measures both CMV-specific Cd4+ and Cd8+ T-cell…
2019 American Transplant Congress
Multilevel Correlates of Immunosuppressive Nonadherence in Kidney Transplant Patients – The Multicenter ADHERE BRAZIL Study
H. Sanders-Pinheiro¹, F. A. Colugnati¹, K. Denhaerynck², E. O. Marsicano¹, J. O. Medina³, S. De Geest², A. ADHERE BRAZIL Study team¹
¹Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Brazil, ²Institute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland, ³Hospital do Rim e Hipertensão/Nephrology, Federal University of São Paulo, São Paulo, Brazil
*Purpose: Nonadherence to immunosuppressive therapy is a risk factor for poor clinical and economic outcomes after kidney transplantation (KT). Brazil, having the largest public and…
2019 American Transplant Congress
Increase in 48 Month Cumulative Acute Rejection Rates in the Most Recent Cohort: The 2018 Transplant Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)
V. Dharnidharka¹, C. Cramer², A. Chua³, A. Moudgil⁴, K. Martz⁵, T. Blydt-Hansen⁶, J. Smith⁷, A. Neu, on Behalf of The NAPRTCS Investigators⁸
¹Washington University in St. Louis, Saint Louis, MO, ²Mayo Clinic, Rochester, MN, ³Duke University, Durham, NC, ⁴Children's National Medical Center, Washington, DC, ⁵Emmes Corporation, Rockville, MD, ⁶BC Children's Hospital, Vancouver, BC, ⁷Seattle Children's Hospital, Seattle, WA, ⁸Johns Hopkins University, Baltimore, MD
*Purpose: The NAPRTCS registry has collected data on children receiving kidney transplants in North America since 1987. The registry has served to document and influence…
2019 American Transplant Congress
Breaking Concepts: 10-year Follow-Up of the Everolimus versus Azathioprine Heart Transplant Multi-National Study
J. A. Kobashigawa¹, R. Starling², E. Passano¹, P. Bernhardt³, B. Azarbal¹, R. Cheng¹, F. Esmailian¹, K. Khush⁴, D. Mancini⁵, J. Patel¹, T. Sato¹, S. Varnous⁶
¹Smidt Heart Institute at Cedars-Sinai, Los Angeles, CA, ²Cleveland Clinic, Cleveland, OH, ³Novartis Pharmaceuticals, Basel, Switzerland, ⁴Stanford University, Palo Alto, CA, ⁵Mount Sinai, New York, NY, ⁶APHP, Pitié‐Salpétrière, Sorbonne University, Paris, France
*Purpose: This study is the 10-year follow-up of a randomized double-blind prospective trial that compared everolimus (1.5 mg or 3 mg) to azathioprine. In this…
2018 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish BK Virus Nephropathy from Acute Rejection in Kidney Transplant Patients with Graft Dysfunction
K. Keslar,¹ P. Gotwald,¹ W. Xu,² A. Zmijewska,³ J. Chen,³ K. Newell,⁴ P. Heeger,⁵ J. Bromberg,⁶ R. Mannon,³ R. Fairchild,¹ The CTOT Consortium.
¹Cleveland Clinic, Cleveland, OH; ²Nanostring Technologies, Seattle, WA; ³University of Alabama at Birmingham, Birmingham, AL; ⁴Emory University, Atlanta, GA; ⁵Icahn School of Medicine at Mt. Sinai, New York, NY; ⁶University of Maryland, Baltimore, MD.
Acute cellular rejection and BK virus nephropathy both cause deteriorating graft function that can lead to graft loss. Distinguishing the two conditions rapidly and accurately…
2018 American Transplant Congress
Identification of Noninvasive and Mechanistically-Informative Biomarkers Predictive of Reversal of Acute Cellular Rejection (ACR) in Kidney Allografts
D. Luan,¹ J. Schwartz,² R. Ding,² T. Muthukumar,² D. Dadhania,² M. Suthanthiran.²
¹University of Michigan, Ann Arbor, MI; ²Weill Cornell Medical College, New York City, NY.
Objective: We determined whether urinary cell mRNAs predict response to anti-rejection therapy in kidney allograft recipients with Banff grade IA or higher ACR biopsies.Methods: We…

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