ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Monitoring"

  • 2018 American Transplant Congress

    Role of BK Virus-Specific T Cell Immune Monitoring for BK Virus-Associated Nephropathy in Kidney Transplant Recipients

    J. Bruminhent,1 S. Srisala,2 C. Klinmalai,3 S. Pinsai,1 S. Watcharananan,1 S. Kantachuvessiri,5 S. Hongeng,4 N. Apiwattanakul.3

    1Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 4Division of Hematology and Oncology, Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 5Division of Nephrology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

    Background: Reduced immunosuppression in a key therapy for BK virus (BKV)-associated nephropathy (BKVAN) in kidney transplant (KT) recipients. A study of immune monitoring against BKV…
  • 2018 American Transplant Congress

    What's Normal? An Evaluation of Pediatric T Cell Markers in Healthy Controls

    M. Sosniuk,1 A. Halpin,1,2,5,6,7 J. Wizniak,7 A. Szkotak,6,7 S. Urschel,1,2,5 L. Ionescu,1,2,5 L. West.1,2,3,4,5,6

    1Dept of Pediatrics, U of Alberta, Edmonton, Canada; 2Alberta Transplant Institute, Edmonton, Canada; 3Dept of MMI, U of Alberta, Edmonton, Canada; 4Dept of Surgery, U of Alberta, Edmonton, Canada; 5Canadian National Transplant Research Program, National, Canada; 6Dept of Laboratory Medicine, U of Alberta, Edmonton, Canada; 7Laboratory Medicine and Pathology, Alberta Health Services, Edmonton, Canada.

    INTRODUCTION: Studying pediatric patients includes challenges such as difficulty obtaining samples, limited normal controls and small volumes. Standardized flow cytometry (FC) lymphocyte immunophenotyping panels are…
  • 2018 American Transplant Congress

    Monitoring of Small Bowel Allografts with Kynurenine Serum Levels

    M. Stangl,1 D. Koliogiannis,1 J. Bucher,1 M. Guba,1 D. Abendroth.2

    1Transplant Center Munich, Klinikum Großhadern, LMU Munich, Munich, Germany; 2Department of Surgery, University of Ulm, Ulm, Germany.

    Long-term success in intestinal transplantation could be significantly improved by the development of a reliable noninvasive marker of rejection, allowing early diagnosis and treatment without…
  • 2017 American Transplant Congress

    NK Cells Respond to CMV Lysate by Inducing IFNγ and CD107a Surface Expression in an Antibody-Dependent Manner: This Represents a Cytokine Flow Cytometry (CFC) Assay That Could Assess Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) as a Marker of CMV Immunity in Transplant Recipients.

    S. Ge, C. Maggie, B.-H. Shin, A. Karasyov, S. Jordan, M. Toyoda.

    Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    Background: Viral infections represent significant morbidity factors for transplant recipients. Tools to assess the efficacy of viral-specific responses are lacking. ADCC is the major antibody-mediated…
  • 2017 American Transplant Congress

    Identification of Promising Targets for Tolerance Induction Following Heart Transplantation.

    K. Klaeske, M.-T. Dieterlen, J. Fischer, J. Hahn, K. Jawad, J. Garbade, F. Mohr, S. Lehmann.

    Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany

    Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells…
  • 2017 American Transplant Congress

    Noninvasive Renal Transplant Graft Monitoring in Single Institution Using Cell-Free DNA in Recipient Plasma via Insertion-Deletion Allele Polymorphism.

    Y. Goh,1 S. Ho,2 L. Raman,1 V. Anantharaman,3 T. Goh,3 S. Koay,2 H. Tiong.1

    1Urology, National University Hospital, Singapore, Singapore; 2Laboratory Medicine, National University Hospital, Singapore, Singapore; 3Nephrology, National University Hospital, Singapore, Singapore

    IntroductionThere is an unmet clinical need in renal transplantation towards early detection of donor organ damage. Serum creatinine(SCr) and biopsies are not ideal.Cell-free donor DNA(cfdDNA)…
  • 2017 American Transplant Congress

    Rejection of Human Kidney Allografts According to BANFF Classification Is Associated with a Chemokine-Enriched Protein Microenvironment in Biopsy Tssue.

    C. Falk,1 K. Daemen,1 J. Keil,1 F. Lehner,2 H. Haller,3 J. Schmitz,4 J.-H. Bräsen,4 C. Blume.5

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Department of Abdominal, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany; 3Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; 4Institute of Pathology, Hannover Medical School, Hannover, Germany; 5Institute for Technical Chemistry, Leibniz University, Hannover, Germany

    Background: Expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection can be defined by distinct signatures. Based on pathological evaluation (BANFF) as…
  • 2017 American Transplant Congress

    Association with Tacrolimus Intraindividual Variability, Acute Microinflammation Based on 1 Year-Transplanted Kidney Biopsy After Transplantation, and Biopsy-Proven Acute Rejection.

    S.-Y. Kim, S.-I. Min, W. Cho, S. Cho, M.-J. Cho, S. Ahn, S.-K. Min, J. Ha.

    Surgery, Seoul National University College of Medicine, Seoul, Korea

    Background: The purpose of this study was to investigate relationship between tacrolimus intraindividual variability (IIV), acute microinflammation (AMI) based on 1 year-transplanted kidney biopsy, and…
  • 2017 American Transplant Congress

    A Novel, Dose-Adjusted Tacrolimus Trough Concentration (TTC) Model for Prediction and Variance Estimation.

    J. Kim,1 S. Wilson,1 N. Undre,2 S. Fei,1 R. Kristy,1 J. Schwartz.1

    1Astellas Pharma Global Development, Inc., Northbrook, IL; 2Astellas Pharma Global Development, Inc., Chertsey, United Kingdom

    Given that a high tacrolimus (tac) intrapatient variability (IPV) increases the risk for a poor kidney transplant (tx) outcome, some experts advocate routine IPV monitoring…
  • 2017 American Transplant Congress

    Prospective Randomized Trial for Predicting CMV Infection According to Baseline CMV-Specific T-Cell Immunity in Kidney Transplant Patients.

    M. Jarque,2 E. Melilli,1 A. Gutierez,3 F. Moreso,4 L. Guirado,5 A. Manonelles,1 J. Cruzado,1,2 S. Luque,2 E. Crespo,2 N. Montero,1 F. Diekman,6 J. Grinyó,1,2 O. Bestard.1

    1Nephrology Dep, Bellvitge Hospital, Barcelona, Spain; 2Nephrology Laboratory, IDIBELL, Barcelona, Spain; 3Kidney Transplant Unit, Hospital Miguel Servet, Zaragoza, Spain; 4Kidney Transplant Unit, Hospital Vall d'Hebrón, Barcelona, Spain; 5Kidney Transplant Unit, Fundació Puigvert, Barcelona, Spain; 6Kidney Transplant Unit, Hospital Clínic, Barcelona, Spain

    Background: Despite the use of either anti-viral prophylaxis (PF) or preemptive (PE) therapy given based on donor/recipient IgG-serostatus, Cytomegalovirus (CMV) reactivation persists after kidney transplantation…
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