ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Articles tagged "Mixed chimerism"

  • 2022 American Transplant Congress

    Acute Graft versus Host Disease (AGVHD) Related to Solid Organ Transplant (SOT) – A Fatal Complication

    H. Shaikh1, J. Awosika1, B. Barakoti1, B. Hambley1, C. Alquist2

    1University of Cincinnati Medical Center, Cincinnati, OH, 2Hoxworth Blood Center, Cincinnati, OH

    *Purpose: This case series highlights our institution's experience with solid-organ transplant (SOT) associated acute graft versus host disease (aGVHD), a rare and deadly complication of…
  • 2022 American Transplant Congress

    Tolerance of Allogeneic Kidneys with Durable (>200 Days) Multilineage Chimerism and Bone Marrow Engraftment in Cynomolgus Macaques

    Y. Tomori1, Y. Hisadome1, D. Eisenson1, K. Takeuchi1, K. Okubo1, C. Huang2, D. Sachs1, M. Sykes1, K. Yamada1

    1CCTI/Surgery and Medicine, Columbia University, New York, NY, 2University of Colorado Denver, Aurora, CO

    *Purpose: We have previously reported that a regimen including anti-CD3 immunotoxin, 45 days of cyclosporine, and pre-transplant total body irradiation (TBI) promoted tolerance of kidney…
  • 2022 American Transplant Congress

    Belatacept Augments Mixed Chimerism in a Novel Nonhuman Primate Kidney Transplant Tolerance Induction Protocol

    S. C. Kim, C. J. Little, J. H. Fechner, P. J. Chlebeck, J. Post, A. D'Alessandro, D. B. Kaufman

    University of Wisconsin, Madison, WI

    *Purpose: A novel protocol of antilymphocyte globulin (ATG), tomotherapy-based total lymphoid irradiation (TomoTLI), and adoptive cellular transfer was developed in a preclinical model of MHC-mismatched…
  • 2022 American Transplant Congress

    Increased Baboon Chimerism After Peripheral Blood Stem Cell Infusion from a Novel GalTKO Pig with Functional Humanized Il-3 Receptor

    E. M. Duggan, N. P. Llore, J. M. Stern, H. Sakai, B. Piegari, K. Bruestle, D. Hajosi, B. Bhola, F. Huang, D. Ekanayake-Alper, D. H. Sachs, M. Sykes, R. J. Hawley, A. D. Griesemer

    Columbia University Irving Medical Center, New York, NY

    *Purpose: The purpose of this study was to investigate whether expression of a humanized IL-3 receptor (hCD123+hCD131) transgene in a GalTKO pig would improve levels…
  • 2021 American Transplant Congress

    Successful Induction of Hematopoietic Chimerism by Dual Inhibition of Mcl-1 and Bcl-2 Without Myeloablative Treatments in Nonhuman Primates

    T. Hirose, D. Ma, G. Lassiter, T. Kawai

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Induction of hematopoietic chimerism by donor bone marrow transplantation (BMT) is essential for achievement of allograft tolerance in clinical HLA mismatched kidney transplantation, while…
  • 2021 American Transplant Congress

    Selective Bcl-2 Inhibition for Induction of Mixed Chimerism and Renal Allograft Tolerance without Myelosupression

    G. Lassiter1, T. Hirose1, H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, A. Cosimi1, P. Cippa2, T. Fehr3, T. Kawai1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland, 3Division of Nephrology, University of Zurich, Zurich, Switzerland

    *Purpose: Immunologic tolerance of renal allograft has been achieved by induction of hematopoietic chimerism through donor bone marrow transplantation (DBMT). The myeloablative and genetic toxicity…
  • 2021 American Transplant Congress

    Effects of IL-2 and/ or Anti-IL6R Therapy on Long-term Cardiac Allograft Survival in Non-Human Primates (NHPs)

    C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, J. A. Morrissette, D. Becerra, T. Costa, A. Dehnadi, I. M. Hanekamp, G. Benichou, J. C. Madsen

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Cardiac allograft tolerance in NHPs has been achieved by our group using a mixed chimerism model with allogeneic bone marrow transplant after non-myeloablative conditioning…
  • 2020 American Transplant Congress

    Interim Experience in a Phase 3 Prospective, Randomized, Multi-Center, Open-Label, Controlled Trial of Cellular Immunotherapy with MDR-101 for Induction of Immune Tolerance in Recipients of HLA-Matched, Living Donor Kidney Transplants

    D. Kaufman1, J. Piper2, M. Stegall3, S. Akkina4, E. Marin5, A. Gaber6, Y. Qasi7, T. Srinivas8, D. Alonso9, A. Patel10, M. Laftavi11, A. Shah12, S. Collette13, E. Stites14, K. Chavin8, S. Crowley15

    1UW, Madison, WI, 2INOVA, Fairfax, VA, 3Mayo, Rochester, MN, 4LUMC, Chicago, IL, 5Yale, New Haven, CT, 6Houston Methodist, Houston, TX, 7USC, Los Angeles, CA, 8UH Cleveland, Cleveland, OH, 9Intermountain, Murray, UT, 10SBMC, Livingston, NJ, 11UH Upstate, Syracuse, NY, 12TJU, Philadelphia, PA, 13CIUSSS, Montreal, QC, Canada, 14UCH, Denver, CO, 15Medeor, San Francisco, CA

    *Purpose: The goals of tolerance in patients with kidney transplants (KTxp) are to eliminate the lifelong need for immunosuppressive drugs (IS) and to prevent graft…
  • 2020 American Transplant Congress

    Orthogonal IL-2 Cytokine-Receptor Pair Capable of Selective Expansion of Regulatory T Cells Facilitates Alloengraftment

    T. Hirai1, F. Simonetta2, L. L. Su3, L. Picton3, J. Baker2, J. Lin4, P. Li4, W. J. Leonard4, K. C. Garcia3, R. S. Negrin2

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA, 3Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA, 4Laboratory of Molecular Immunology, National Institutes of Health, Bethesda, MD

    *Purpose: Adoptive transfer of regulatory T cells (Tregs) has been shown to improve alloengraftment in animal models. However, ex vivo Treg expansion for the purpose…
  • 2020 American Transplant Congress

    Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment

    Y. Guo1, F. Messner1, B. Oh1, G. Furtmüller1, W. Lee1, D. Cooney1, L. Luznik2, G. Brandacher1

    1Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 2Hematology, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
  • 1
  • 2
  • 3
  • …
  • 7
  • Next Page »

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences