2021 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome. We have previously reported that following…2021 American Transplant Congress
Transforming Growth Factor-Beta Induced Myeloid-Derived Suppressor Cells Promote Transplant Immune Tolerance
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells derived from bone marrow with immunosuppressive effect, which contribute to the establishment of transplant…2021 American Transplant Congress
Islet Isograft Transplantation Improves Insulin Sensitivity in a Murine Model of Type 2 Diabetes
Asan Medical Center, Seoul, Songpa, Korea, Republic of
*Purpose: Type 2 diabetes develops in the presence of chronic overnutrition and genetic susceptibility, and causes insulin resistance and relative insulin deficiency. We hypothesized that…2021 American Transplant Congress
Single-cell Rna Sequencing of Latent Murine Cytomegalovirus Infected Lung Transplants
*Purpose: Analyze the transcriptomics of mouse lung cells with and without latent infection of cytomegalovirus (CMV) before and after transplantation and identify key cell types…2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…2021 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…2021 American Transplant Congress
Laminins Differentially Regulate Adaptive Alloimmune Responses
1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal cell expressed laminin α4 (Lama4) and laminin α5 (Lama5) fibers are associated with tolerance and immunity, respectively. They regulate cell…2021 American Transplant Congress
TOLS are Novel Regulatory TLOs with A B Cell Signature
1Massachusetts General Hospital, Boston, MA, 2Co-Senior Authors, Boston, MA
*Purpose: Our previous studies suggest that a DBA/2 kidney graft is accepted by a MHC-fully mis-matched C57/BL6 recipient. Accepted renal allografts exhibited lymphoid like structures…2021 American Transplant Congress
Increased T Cell Cross-dressing in Accepted Kidney Allografts
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) develop tolerance while other combinations do not (e.g. B6 to DBA/2). We…2021 American Transplant Congress
Single-Cell RNA-seq Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in the Mouse
*Purpose: Transplant rejection remains a major barrier to graft survival and involves a diversity of cell types. But the heterogeneity in a given cell type…
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