2022 American Transplant Congress
Marginal Zone B Cells Support T Cell Reconstitution Following ATG Lymphoablation in Heart Allograft Recipients.
Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphoablation with anti-thymocyte globulin (ATG) is a common therapy in solid organ transplantation. However homeostatic proliferation of pre-existing memory T cells undermines the graft-prolonging…2022 American Transplant Congress
Iguratimod Alleviates Endothelial to Mesenchymal Transition by Inducing AMBRA1/PARKIN-Dependent Mitophagy and Inhibiting NLRP3 Activation During Renal Allograft Interstitial Fibrosis
*Purpose: Chronic renal graft dysfunction (CAD) is caused by multiple factors, including glomerular sclerosis, inflammation, interstitial fibrosis and tubular atrophy (IF/TA). However, the most prominent…2022 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Immune responses to self antigens develop following organ transplantation. Multiple studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome.…2022 American Transplant Congress
Long-Term Kidney Allotransplant Acceptance is Defined by a Shift from a T Cell to a B Cell Rich Immune Microenvironment Within the Graft
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations, such as DBA/2J to C57BL/6 (B6). Tolerant renal grafts develop aggregates of…2022 American Transplant Congress
M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod
*Purpose: After kidney transplantation, Antibody Mediated Rejection (ABMR) is the main factor affecting the long-term survival of kidney transplantation. Previous studies have confirmed that macrophage…2022 American Transplant Congress
Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance
*Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…2022 American Transplant Congress
CCR2 Antagonism Blocks Microbiota Pro-Inflammatory Effects on Lymph Node Architecture
1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD
*Purpose: Fecal microbiota transfer (FMT) of Desulfovibrio desulfuricans (Desulfo) triggers a pro-inflammatory immune state, causing decreased laminin α4:α5 ratios in the lymph node (LN), increased…2022 American Transplant Congress
Chronic Ethanol Exposure Prolongs Murine Allograft Survival
Department of Surgery, Emory University, Atlanta, GA
*Purpose: Alcoholic liver disease is the leading indication for liver transplantation in the United States, and patients are increasingly transplanted without the traditional six month…2022 American Transplant Congress
Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts
*Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…2022 American Transplant Congress
Recipient Neutrophil Production of Myeloperoxidase is Required for NK Cell Activation During Acute Antibody Mediated Allograft Rejection
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…
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