ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2022 American Transplant Congress

    Pro- and Anti-Tolerogenic Microbiota Induce Distinct Gut Microbiome Metabolic Pathways and Loco-Regional Immune Responses

    S. J. Gavzy1, R. Lakhan2, J. Iyyathurai2, V. Saxena2, Z. L. Lee2, B. Ma2, E. Mongodin2, J. S. Bromberg2

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD

    *Purpose: Colitis-associated Desulfovibrio desulfuricans (Desulfo) induces pro-inflammatory cytokine responses in dendritic cell and macrophage cell lines as well as primary cells. In contrast, Bifidobacterium pseudolongum…
  • 2022 American Transplant Congress

    Bioink Based on the DECM for 3D-Bioprinting of Bionic Pancreas – First Results of Animal

    M. Klak1, K. Kosowska1, T. Bryniarski1, I. Lojszczyk1, T. Dobrzanski2, G. Tymicki1, A. Filip1, A. A. Szczepankiewicz3, R. Olkowski4, A. Kosowska4, A. Berman1, A. Kaminski4, M. Wszola1

    1Foundation of Research and Science Development, Warsaw, Poland, 2Polbionica LTD, Warsaw, Poland, 3Institute of Experimental Biology M. Nencki PAN, Warsaw, Poland, 4Medical University of Warsaw, Warsaw, Poland

    *Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and…
  • 2022 American Transplant Congress

    P2X7R Inhibition Impairs In Vitro Training of Macrophages

    H. H. Lancia1, R. Sanchez2, A. G. Lellouch1, C. L. Cetrulo1, J. Ochando3, G. Benichou4

    1Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 4Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Macrophage training and ATP-mediated P2X7R signaling are unrelated key elements of the innate immune response associated with allotransplant rejection. In the present study, we…
  • 2022 American Transplant Congress

    Type 1 Natural Killer T-cells: Key Mediators of Ischemia- Reperfusion Injury in Hepatic Steatosis

    J. R. Liggett1, J. Kang1, K. Loh1, K. Oza1, Y. Cui1, D. Kwon2, H. Li3, B. Kallakury2, T. Fishbein1, W. Cui1, K. Khalid1, A. H. Kroemer1

    1MedStar Georgetown Transplant Institute, Washington, DC, 2Pathology, MedStar Georgetown University Hospital, Washington, DC, 3Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) poses a significant risk in liver transplantation and hepatic resection and is further exacerbated by hepatic steatosis. Type 1 Natural…
  • 2022 American Transplant Congress

    Portal Hypertension Inhibits the Antitumor Effect of Liver-Resident NK Cells Through IL-33 Signal

    Y. Imaoka, M. Ohira, K. Sato, K. Imaoka, R. Nakano, Y. Tanaka, H. Ohdan

    Hiroshima University, Hiroshima, Japan

    *Purpose: Portal vein hypertension (PHT) after living donor liver transplantation (LDLT) is known to have associated with poor prognosis. Among patients with hepatocellular carcinoma (N=…
  • 2022 American Transplant Congress

    Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping

    O. C. Rodriguez1, J. R. Liggett2, J. Kang2, K. Loh2, Y. Lee1, N. Sang1, B. He1, Y. Cui2, K. Oza2, D. Kwon3, B. Kallakury3, T. Fishbein2, W. Cui2, K. Khan2, C. Albanese1, A. Kroemer2

    1Lombardi Comprehensive Cancer Center and the Center for Translational Imaging, Georgetown University Medical Center, Washington, DC, 2MedStar Georgetown Transplant Institute, Washington, DC, 3Pathology, MedStar Georgetown University Hospital, Washington, DC

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…
  • 2022 American Transplant Congress

    Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance

    W. Burlingham1, E. Jankowska-Gan2, J. Fechner3, C. Little2, J. Sullivan4, D. Foley1

    1University of Wisconsin, Madison, WI, 2Surgery-Transplant Division, University of Wisconsin, Madison, WI, 3Surgery-Transplant Division, University of Wisconsin-Madison, Madison, WI, 4Surgery, University of Wisconsin, Madison, WI

    *Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…
  • 2022 American Transplant Congress

    Autophagy is an Important Factor in the Development of Fibrosis Following Renal Injury; Implications for Post-Transplant IFTA

    R. Lopez-Soler1, X. Ding2, Q. Zang3

    1Tansplant, Surgery, Edward Hines VA Medical Center, Hines, IL, 2Pathology, Loyola University Medical Center, Maywood, IL, 3Surgery, Loyola University Medical Center, Maywood, IL

    *Purpose: Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. There is currently no effective therapy.…
  • 2022 American Transplant Congress

    Protective Immunity Against a Murine Epstein-Barr Virus Homolog is Preserved During CD11b-CD154 Blockade

    K. L. Alexander, D. Liu, M. L. Ford

    Emory University Transplant Center, Emory University, Atlanta, GA

    *Purpose: CD154 pathway antagonism has shown to be a promising target for inducing long-time graft survival, in some cases showing efficacy that is superior to…
  • 2021 American Transplant Congress

    Single-Cell RNA-seq Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in the Mouse

    C. Wu1, Y. Tang1, X. Shi1, X. He1, X. Li2

    1The First Affiliated Hospital,Sun Yat-sen University, Guangzhou, China, 2Immunobiology & Transplant Sciences Houston Methodist Hospital, Houston, TX

    *Purpose: Transplant rejection remains a major barrier to graft survival and involves a diversity of cell types. But the heterogeneity in a given cell type…
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