2017 American Transplant Congress
B Cells in Liver Transplant Tolerance.
In mice liver transplantation, the liver allografts can be accepted across fully mismatched MHC without immunosuppression. After transplantation, T cells infiltrate into the graft in…2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…2017 American Transplant Congress
Ethylene Carbodiimide Fixed Donor Splenocytes Combined with α-1 Antitrypsin Induce Indefinite Donor Specific Protection to Mice Cardiac Allografts.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Peritransplant infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) induces protection of islet and cardiac allografts. However, pro-inflammatory cytokine production during the peritransplantation period may negate…2016 American Transplant Congress
Heat Shock Protein 90 Inhibitor 17DMAG Is a Potential New Therapeutic Agent Against Acute Allograft Rejection.
Purpose: We have previously demonstrated that Heat shock protein 90 (HSP90) plays a role in the development of acute rejection (AR) in organ transplantation. To…2016 American Transplant Congress
Tracking of Endogenous Graft-Reactive Tregs Reveals Their Peripheral Enrichment During Transplantation Tolerance.
Purpose: Our goal for this study was to determine the relative fates of endogenous Foxp3- conventional (Tconv) and Foxp3+ regulatory T cells (Tregs) specific for…2016 American Transplant Congress
Toll-Like Receptor (TLR) 9-Induced Resistance to Murine Cardiac Allograft Tolerance Is Dependent Upon C3a and C5a Receptor (C3aR/C5aR) Signaling.
TLR stimulation has been shown by others to prevent costimulatory blockade-induced allograft tolerance. Immune cell derived complement activation products C3a and C5a amplify inflammation, enhance…2016 American Transplant Congress
Aging Is Critically Impacting the Efficacy of Immunosuppressants.
Immunosenescence is broadly affecting alloimmunity with major implications on immunosuppression. Older recipients have thus far been mostly excluded from clinical trials. Here, we dissected the…2016 American Transplant Congress
Absence of Receptors for C3a or C5a Prevent Alloreactive CD8 T Effector Cell (Teff) Expansion but Differentially Impact Memory (Tmem) Persistence Posttransplantation.
As Tmem are known barriers to transplant survival and tolerance in animals and human transplant recipients, understanding factors that drive the formation and survival of…2016 American Transplant Congress
C5a Induces CSF1-Dependent Regulatory Macrophage (Mreg) Development Required for Murine Allograft Tolerance.
Icahn School of Medicine at Mount Sinai, New York, NY.
Anti-CD40L (MR1) induced heart transplant tolerance has been recently shown to be dependent on early post-transplant intragraft accumulation of CD11b+Ly6CLoLy6G- DC-SIGN expressing Mreg that develop…2016 American Transplant Congress
Neonatal Tolerance to Blood Group A-Antigen in a Mouse Model of ABO-Incompatible Heart Transplantation (ABOi HTx).
Purpose: ABOi HTx can be performed safely in infants due to lack of natural anti-A/B antibodies (Ab), in contrast to adults. Following ABOi HTx, B…
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