2016 American Transplant Congress
Sphingosine-1 Phosphate Receptor 1 Agonist SEW2871 Ameliorates Hepatocellular Injury on Ischemic Reperfusion in Mice: A New Therapeutic Target.
Introduction: We had reported that activated protein C (APC) administration had cytoprotective effects on hepatic ischemic reperfusion (IR) injury in rat and mice models. Recent…2016 American Transplant Congress
mTORC2 Negatively Regulates Dendritic Cell (DC) Metabolism and the Allostimulatory Function of Donor DCs in Organ Transplantation.
The mechanistic target of rapamycin (mTOR) is a kinase that functions in at least two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play…2016 American Transplant Congress
Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.
Surgery, MGH/Harvard Medical School, Boston, MA.
T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…2016 American Transplant Congress
Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.
Calorie restriction or starvation (fasting) has some beneficial effects on prolongation of life and increased resistance to stress. Calorie restriction has also been shown to…2016 American Transplant Congress
Role of NRP1 in CD4+ T Cell Allo-Activation.
Department of Surgery, Boston Children's Hospital, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…2016 American Transplant Congress
Adiponectin Is Produced by Leukocytes Infiltrating Renal Transplants.
Immunology, Cleveland Clinic, Cleveland, OH.
Fat is now recognized as a source of immunologically significant cytokines. Adiponectin, the most abundant adipokine, is usually classified as an anti-inflammatory cytokine because decreased…2016 American Transplant Congress
IgM Treatment Successfully Prevents Type 1 Diabetes by Dysregulation of Pancreatic MicroRNAs with Immunomodulatory Roles.
Type 1 Diabetes (T1D) is hallmarked by beta-cells destruction. We aimed to identify specific pancreatic microRNAs (miRNA) as potential biomarkers for T1D prediction and diagnosis,…2016 American Transplant Congress
Profiling Metabolic Differences Between Graft- vs. Pathogen-Elicited CD8+ T Cell Responses.
The challenge of immune modulation in transplantation is to inhibit pathologic alloreactivity while minimizing off-target toxicities and preserving protective immunity. Data have emerged demonstrating the…2016 American Transplant Congress
Imaging Cell Biology In Vivo with Intravital-Microscopy.
Background: Despite current immunosuppressive therapy, many recipients endure multiple episodes of acute rejection. The interplay between dendritic cells (DCs) and T cells plays a central…2016 American Transplant Congress
Complement Receptor C5aR2 Deletion in Kidney Transplantation in Mice Attenuates Renal Damage.
ObjectiveThe complement receptors C5aR1 and C5aR2 serve distinct roles in immune regulation. In kidney transplantation the early post-implant ischemia reperfusion injury (IRI) causes rapid complement…
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