ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2019 American Transplant Congress

    Estrogen Mediated Protection in Renal Ischemia Reperfusion Injury (IRI) is Extrinsic to the Kidney

    D. D. Aufhauser1, S. J. Concors1, P. T. Hernandez1, Z. Wang1, L. Krumeich1, D. R. Murken1, G. Ge1, W. W. Hancock2, M. H. Levine1

    1Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2Pathology, Children's Hospital of Philadelphia, Philadelphia, PA

    *Purpose: IRI causes morbidity in renal transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required so that strategies…
  • 2019 American Transplant Congress

    Tolerance Induction by Myeloid Progenitor Cells Modulates T and B Cell Responses

    J. Domen, Y. Li

    Allergy, Asthma and Immunology, Children's Mercy Hospital, Kansas City, MO

    *Purpose: Modulation of the immune system using cellular therapy is an increasingly attractive option to prevent solid organ graft rejection, while at the same time…
  • 2019 American Transplant Congress

    Sequestration of PLIN2 Regulates High-Fat Diet Induced Metabolic Syndrome and Nonalcoholic Fatty Liver Disease in a Mouse Model of Ischemia Reperfusion Injury

    K. Loh1, X. Liu1, L. Belyayev1, C. Albanese2, W. Cui1, T. M. Fishbein1, K. M. Khan1, A. Kroemer1

    1Transplant, MedStar Georgetown Transplant Institute, Washington, DC, 2Oncology, Georgetown University, Washington, DC

    *Purpose: This study aimed to define characteristics and mechanisms leading to nonalcoholic fatty liver disease and metabolic syndrome in a fatty liver mouse model that…
  • 2019 American Transplant Congress

    Implication of Melanocortin Receptors in Alloimmunity

    M. Uehara, B. S. Al Dulaijan, J. Azzi, R. Abdi

    Transplantation Research Center, Renal, Brigham and Women's Hospital, Boston, MA

    *Purpose: Recent studies have indicated the importance of the melanocortin pathway in the regulation of immune responses. In particular, the role that melanocortin receptors (MCRs)…
  • 2019 American Transplant Congress

    mTOR Inhibitors Enhance Antitumor Activity of Liver Resident NK Cells

    J. Saparbay, Y. Tanaka, A. Seidakhmetov, H. Ohdan

    Gastroenterology and transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
  • 2019 American Transplant Congress

    Lineage Tracing Identifies C-­Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases

    E. B. Rangel1, E. Higuti-Sousa1, G. Goss2, B. Goldstein2, B. Seidler3, D. Saur3, S. A Gomes4, J. M. Hare2

    1Albert Einstein Hospital, São Paulo, Brazil, 2University of Miami, Miami, FL, 3Medizinische Klinik, Technische Universität München, Munich, Germany, 4University of São Paulo, São Paulo, Brazil

    *Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…
  • 2019 American Transplant Congress

    Sex Specific Regulation of Podocyte-Specific Genes and Proteins Determines Glomerular Response to mTOR Inhibition

    A. Kusch1, O. AlDiab2, D. Gürgen2, C. Sünkel3, F. Grahammer4, M. Rinschen5, T. Huber4, N. Rajewsky3, D. Dragun2

    1Medizinische Klinik m. S. Nephrologie und Internistische Intensivmedizin, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Medizinische Klinik m. S. Nephrologie und internistische Intensivmedizin, Charité Universitätsmedizin Berlin, Berlin, Germany, 3Max-Delbrück Center for Molecular Medicine, Berlin, Germany, 4III. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg - Eppendorf, Hamburg, Germany, 5CECAD Research Center, Universitätsklinikum Köln, Köln, Germany

    *Purpose: mTOR inhibitors are increasingly used in transplantation with high interindividual variation in proteinuric responses. Although males have higher prevalence and faster progression of glomerular…
  • 2019 American Transplant Congress

    Treg Suppressor Function within Allografts is Required for Tolerance

    J. Ossart, A. Pena, H. Dai, L. Bauer, A. Williams, G. Camirand

    Surgery, University of Pittsburgh, Pittsburgh, PA

    *Purpose: The role of regulatory CD4+Foxp3+ T cells (Treg) suppressor function within allografts in tolerance remains unclear. Thus, we sought to directly address: 1) whether…
  • 2019 American Transplant Congress

    Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft

    E. Yin, M. Uchiyama, Y. Yamamoto, M. Niimi

    Teikyo University, Tokyo, Japan

    *Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
  • 2019 American Transplant Congress

    Differential Impact of Donor and Recipient Age on Post-Lung Transplantation Outcomes

    K. Patel1, C. Li1, C. Wallace1, J. Kilkenny1, D. P. Allen1, S. Nadig1, M. Goddard2, C. Krieg1, C. Atkinson1

    1Surgery, Medical University of South Carolina, Charleston, SC, 2Pathology, Royal Papworth Hospital NHS Trust, C, SC

    *Purpose: Donor and recipient age at the time of lung transplantation (LTx) have been implicated in poor patient outcomes. The underlying mechanisms driving these effects…
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