2020 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis and immune regulation through the activation…2020 American Transplant Congress
Microbiota Modulates Ischemia-Reperfusion Injury in Mouse Liver Transplantation
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor in orthotopic liver transplantation (OLT). As host microbiota may associate with health or disease, antibiotics (Abx)…2020 American Transplant Congress
Mass-Spectrometry Based Discovery of Tubular Injury Marker in Chronic Kidney Disease
*Purpose: Renal tubular injury and interstitial fibrosis are inevitable processes in the progression of chronic kidney disease (CKD). The purpose of this study is to…2020 American Transplant Congress
In-Depth Assessment of Ischemia/Reperfusion Injury in a Murine Model of Hindlimb Transplantation
*Purpose: Static cold storage (SCS) still represents the gold standard for organ and tissue preservation in transplantation. Ischemia/reperfusion injury (IRI) that occurs due to the…2020 American Transplant Congress
Reactivation of Murine Polyomavirus Replication by Renal Ischemia-Reperfusion Injury and Immunosuppression
*Purpose: Polyomavirus (PyV) nephropathy is an important cause of graft failure after renal transplantation. Its pathogenesis is associated with immunosuppression (IM) and renal ischemia-reperfusion injury…2020 American Transplant Congress
Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment
*Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…2020 American Transplant Congress
Cervical Total Arterial Anastomosis Mouse-to-Rat Heterotopic Heart Xenotransplantation
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Xenotransplantation is an effective way to solve the problem of donor shortage. However, clinical use of xenotransplantation is currently limited due to immunological challenges.…2020 American Transplant Congress
Naïve B Cells Regulation by TLR-Breg Cells In Vitro
Center for Transplant Science, MGH, Boston, MA
*Purpose: Regulatory B cells (Bregs) have shown great potential in cell therapies for murine organ transplantation by inhibiting the proliferation of cytotoxic and helper T…2019 American Transplant Congress
Development and Characterization of Human-Derived Xenograft Model for Hepatocellular Carcinoma
*Purpose: Hepatocellular carcinoma (HCC) is rising in the USA and treatment options are limited. There is no convenient animal model for HCC to study novel…2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…
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