Articles tagged "Metabolic disease"

2020 American Transplant Congress
Functional Changes in Metabolic and Malignancy Associated Bacterial Genes in the Post Transplant Intestinal Microbiome
M. Bhat¹, S. Sivaraj¹, E. Pasini¹, J. Copeland², J. Allard³, A. Humar¹
¹Multi-Organ Transplant, UHN, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³UHN, Toronto, ON, Canada
*Purpose: Long-term survival of liver transplant (LT) recipients is affected by metabolic and malignant complications. The aim of our study was to examine changes in…
2020 American Transplant Congress
Liver Transplantation for Pediatric Genetic and Metabolic Liver Disease: A Single-Center Experience
S. Hassan¹, K. Mysore¹, D. N. Cerminara², K. E. Hosek³, M. Faraone⁴, R. Sigereddi⁵, R. Ackah⁵, A. Rana⁶, J. Goss⁶, T. Galvan⁶
¹Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ²Pharmacy, Texas Children's Hospital, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ³Outcomes and Impact Service, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁴Department of Surgery, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁵Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁶Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX
*Purpose: Pediatric liver transplantation (LT) is an established treatment for a myriad of liver diseases most notably biliary atresia and urea cycle defects. In the…
2020 American Transplant Congress
Long-Term Pediatric Outcomes of Simultaneous vs. Sequential Liver-Kidney Transplantation: A Review of the UNOS Database
K. Goli¹, A. Rana¹, J. Goss¹, T. Miloh²
¹Baylor College of Medicine/Texas Children's Hospital, Houston, TX, ²University of Miami, Houston, TX
*Purpose: The long-term pediatric outcomes of simultaneous liver-kidney (SLK) transplantation and sequential liver and kidney transplantation, liver after kidney (LAK) and kidney after liver (KAL),…
2020 American Transplant Congress
Impact of Dialysis and Diabetes on Survival in Recipients of Combined Heart-Kidney Transplant
J. Parekh¹, H. Chau², G. Schnickel², J. Berumen², K. Mekeel²
¹University of California, San Diego, La Jolla, CA, ²Surgery, University of California, San Diego, La Jolla, CA
*Purpose: Mounting data shows a survival benefit of combined heart-kidney transplantation in patients with heart and renal failure. However, little has been done to understand…
2020 American Transplant Congress
Intravenous Administration of Mitochondria Minimizes Liver Ischemia Reperfusion Injury in Lean and Diet Induced Obese Mice
T. Rousselle¹, E. Patterson¹, C. Kuscu¹, J. Pierre², C. Kuscu¹, J. Eason¹, D. Maluf¹, V. Mas¹, A. Bajwa¹
¹Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ²Dept of Pediatrics, UTHSC, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…
2020 American Transplant Congress
Long-Term Metabolic Control and Health Outcomes in Maple Syrup Urine Disease Following Liver Transplantation in Children and Young Adults
C. Ewing¹, K. Soltys², K. Strauss³, G. Mazariegos², R. Sindhi², J. Vockley², P. McKiernan², R. Squires², G. Bond², A. Khanna², J. Squires²
¹School of Medicine, University of Pittsburgh, Pittsburgh, PA, ²Children's Hospital of Pittsburgh, Pittsburgh, PA, ³Clinic for Special Children, Strausburg, PA
*Purpose: Determine outcomes and branch-chain amino acid (BCAA - leucine [LEU], isoleucine [ISO], and valine [VAL]) levels at 1-3, 4-7, and 8-10 years for patient’s…
2020 American Transplant Congress
Domino Transplantation – Expanding the Liver Donor Pool to the Pediatric Recipient
U. Ekong¹, N. Yazigi¹, K. Khan¹, S. Kaufman¹, K. Chapman², E. Leon², N. Ah Mew², A. Kroemer¹, R. Girlanda¹, J. Hawksworth¹, C. Matsumoto¹, T. Fishbein¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Genetics, Children's National Hospital, Washington, DC
*Purpose: Background: Maple syrup urine disease (MSUD) is an inherited autosomal recessive metabolic disorder of amino acid metabolism, caused by a defect of the branched-chain…
2020 American Transplant Congress
Sleeve Gastrectomy Compared with Gastric Bypass for Morbidly Obese Liver Transplant Candidates: A Decision Analysis
R. A. Choudhury¹, D. Yoeli¹, G. Hoeltzel², H. B. Moore¹, H. Yaffe¹, K. R. Dumon³, N. N. Williams³, P. L. Abt⁴, K. D. Conzen¹, J. J. Pomposelli¹, E. A. Pomfret¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³Department of Surgery, University of Pennsylvania Hospital, Philadelphia, PA, ⁴Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA
*Purpose: The use of bariatric surgery has increased for morbidly obese liver transplant candidates for whom placement on the waitlist is often restricted until they…
2020 American Transplant Congress
Long Term Outcome of Patients Transplanted for Non Alcoholic Steatohepatitis Related Cirrhosis
W. Alhamoudi¹, I. Salih², S. Yousif², M. Shawkat³, K. Bzeizi², S. Alghamdi², A. Albenmousa², D. Broering²
¹Medicine, King Saud University, Riyadh, Saudi Arabia, ²Liver Transplant, King Faisal Specialist Hospital, Riyadh, Saudi Arabia, ³Internal Medicine, Minia University, Minia, Egypt
*Purpose: Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide. Cirrhosis secondary to Nonalcoholic Steatohepatitis (NASH) is projected to…
2020 American Transplant Congress
Progression of Insulin Resistance after Liver Transplantation – Prospective Study
I. Mikova¹, D. Erhartova¹, K. Dvorakova¹, P. Sedivy², M. Drobny², M. Dezortova², M. Hajek², M. Cahová³, H. Dankova³, E. Sticova⁴, V. Lanska⁵, P. Trunecka¹
¹Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ³Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁵Medical Statistics Unit, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Insulin resistance (IR) plays an important role in pathogenesis of nonalcoholic fatty liver disease (NAFLD) and other diseases. The data about prevalence and evolution…