Articles tagged "Metabolic disease"

2020 American Transplant Congress
Perioperative Management and Post-Liver Transplantation Outcomes in Methylmalonic Acidemia, Propionic Acidemia and Urea Cycle Disorders: 20 Years’ Experience
P. Vuong¹, N. Ebel², A. Brubaker¹, P. Than¹, C. Baker², A. Pedroza¹, K. Taylor¹, S. Conlon¹, D. Romero¹, G. Enns², C. Esquivel¹
¹Surgery, Stanford University, Palo Alto, CA, ²Pediatrics, Stanford University, Palo Alto, CA
*Purpose: To examine long-term outcomes after liver transplantation for organic acidemias and urea cycle defects at our center which utilizes standardized pre-, peri- and post-operative…
2020 American Transplant Congress
Assessment of Sarcopenia and Obesity by Bioelectrical Impedance Analysis in Transplant and Hepatobiliary Populations
J. Konel¹, T. Kitajima², L. Arevalo¹, N. Murray¹, T. Pietrowsky², D. Venkat², H. Gonzalez², M. Samaniego², M. Abouljoud², S. Nagai²
¹Wayne State University School of Medicine, Detroit, MI, ²Henry Ford Transplant Institute, Detroit, MI
*Purpose: Sarcopenia and obesity are common among transplant and hepatobiliary patients; however, current methods of measuring these risk factors may provide an inadequate representation of…
2020 American Transplant Congress
Selectively Transplanting Moderately to Severely Macrosteatotic Grafts: Does Recipient Metabolic Environment Affect Outcomes?
P. J. Altshuler, A. Rios Diaz, O. Shaheen, A. P. Shah, W. R. Maley, A. Frank, C. Ramirez, J. Glorioso, H. Dang, A. S. Bodzin
Department of Surgery, Thomas Jefferson University, Philadelphia, PA
*Purpose: As incidence of Non-Alcoholic Steatohepatitis (NASH) cirrhosis rises, organ utilization remains stagnant. Recently, it has been shown that selective utilization of >30% macrosteatotic grafts…
2020 American Transplant Congress
Pediatric Liver Transplantation for Metabolic Liver Diseases versus Biliary Atresia: Single Center Experience
A. M. Elsabbagh, K. M. Khan, A. A. Amin, S. S. Kaufman, N. A. Yazigi, T. M. Fishbein
MedStar Georgetown Transplant Institute, Georgetown University Hospital, Washington, DC
*Purpose: The main indication for LT in children has been biliary atresia (BA). Recent advances in surgical management and the development of new immunosuppressants have…
2020 American Transplant Congress
Functional Changes in Metabolic and Malignancy Associated Bacterial Genes in the Post Transplant Intestinal Microbiome
M. Bhat¹, S. Sivaraj¹, E. Pasini¹, J. Copeland², J. Allard³, A. Humar¹
¹Multi-Organ Transplant, UHN, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³UHN, Toronto, ON, Canada
*Purpose: Long-term survival of liver transplant (LT) recipients is affected by metabolic and malignant complications. The aim of our study was to examine changes in…
2020 American Transplant Congress
Liver Transplantation for Pediatric Genetic and Metabolic Liver Disease: A Single-Center Experience
S. Hassan¹, K. Mysore¹, D. N. Cerminara², K. E. Hosek³, M. Faraone⁴, R. Sigereddi⁵, R. Ackah⁵, A. Rana⁶, J. Goss⁶, T. Galvan⁶
¹Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ²Pharmacy, Texas Children's Hospital, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ³Outcomes and Impact Service, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁴Department of Surgery, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁵Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁶Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine/ Texas Children's Hospital, Houston, TX
*Purpose: Pediatric liver transplantation (LT) is an established treatment for a myriad of liver diseases most notably biliary atresia and urea cycle defects. In the…
2020 American Transplant Congress
Long-Term Pediatric Outcomes of Simultaneous vs. Sequential Liver-Kidney Transplantation: A Review of the UNOS Database
K. Goli¹, A. Rana¹, J. Goss¹, T. Miloh²
¹Baylor College of Medicine/Texas Children's Hospital, Houston, TX, ²University of Miami, Houston, TX
*Purpose: The long-term pediatric outcomes of simultaneous liver-kidney (SLK) transplantation and sequential liver and kidney transplantation, liver after kidney (LAK) and kidney after liver (KAL),…
2020 American Transplant Congress
Impact of Dialysis and Diabetes on Survival in Recipients of Combined Heart-Kidney Transplant
J. Parekh¹, H. Chau², G. Schnickel², J. Berumen², K. Mekeel²
¹University of California, San Diego, La Jolla, CA, ²Surgery, University of California, San Diego, La Jolla, CA
*Purpose: Mounting data shows a survival benefit of combined heart-kidney transplantation in patients with heart and renal failure. However, little has been done to understand…
2020 American Transplant Congress
Intravenous Administration of Mitochondria Minimizes Liver Ischemia Reperfusion Injury in Lean and Diet Induced Obese Mice
T. Rousselle¹, E. Patterson¹, C. Kuscu¹, J. Pierre², C. Kuscu¹, J. Eason¹, D. Maluf¹, V. Mas¹, A. Bajwa¹
¹Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ²Dept of Pediatrics, UTHSC, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics within cells with increased mitochondrial swelling and reactive oxygen species and that ultimately degrade of cellular function. Ischemia reperfusion injury…
2020 American Transplant Congress
Long-Term Metabolic Control and Health Outcomes in Maple Syrup Urine Disease Following Liver Transplantation in Children and Young Adults
C. Ewing¹, K. Soltys², K. Strauss³, G. Mazariegos², R. Sindhi², J. Vockley², P. McKiernan², R. Squires², G. Bond², A. Khanna², J. Squires²
¹School of Medicine, University of Pittsburgh, Pittsburgh, PA, ²Children's Hospital of Pittsburgh, Pittsburgh, PA, ³Clinic for Special Children, Strausburg, PA
*Purpose: Determine outcomes and branch-chain amino acid (BCAA - leucine [LEU], isoleucine [ISO], and valine [VAL]) levels at 1-3, 4-7, and 8-10 years for patient’s…