2018 American Transplant Congress
The Role of pDCs in Formation of Treg-Rich Organized Lymphoid Structures in Spontaneously Accepted Murine Kidney Allografts is Dependent on Mismatching of MHC Class II Molecules at the H2-I-Ab Locus
Introduction: Our lab has demonstrated that murine kidney allografts are spontaneously accepted in specific donor-recipient strain combinations. Histologic examination of spontaneously accepted DBA/2J (DBA) kidneys…2018 American Transplant Congress
Informatics Tools for Mapping Molecular HLA Typing Data to UNOS Antigen Equivalencies
Introduction:Molecular HLA typing must be converted to antigen equivalencies for entry into the UNOS database, UNet. Maintaining an up-to-date mapping table for this purpose has…2018 American Transplant Congress
Comparative Analysis of Bone Marrow versus Blood Monocyte-Derived Regulatory Dendritic Cells for Evaluation in a Miniature Swine Vascular Composite Allotransplantation Model
Background: Dendritic cell therapy is a promising approach to reduced dependence on immunosuppressive drugs and for the promotion of tolerance in transplant recipients. Our aim…2017 American Transplant Congress
Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.
Yale School of Medicine, New Haven, CT
Human endothelial cells (ECs) derived from cord blood progenitors have significant replicative potential and are thus well suited for use in tissue engineering of vascularized…2017 American Transplant Congress
Quantity and Functions of CD4–CD8– Double Negative (DN) αβ T Cells in Kidney Is MHC Dependent.
Johns Hopkins University, Baltimore, MD
Background: Prior studies have established important roles of CD4+ T cells, natural killer T cells, and CD4+CD25+FoxP3+ Tregs in kidney ischemia reperfusion injury (IRI) pathogenesis.…2016 American Transplant Congress
Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.
Surgery, MGH/Harvard Medical School, Boston, MA.
T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…2016 American Transplant Congress
MHC/HLA-Specific IgE in Allotransplantation.
Background: Donor-specific antibodies (DSA) are recognized as important factors in determining outcome in renal transplantation.Typically DSAs of the IgG isotype are measured, but little is…2015 American Transplant Congress
Mesenchymal Stem Cells Enhance Rejection Free and Overall Islet Allograft Survival
The purpose of this study was 1) to assess the effect of mesenchymal stem cells (MSC) on intrahepatic, allogeneic islet survival in a cynomolgus monkey…2015 American Transplant Congress
Correlation Between C3d-Binding De Novo Donor Specific HLA Antibodies and Rejection in Kidney Transplant Recipients
Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Donor specific antibodies (DSA) directed against HLA arising de novo post-kidney transplant are a major cause of graft loss, termed antibody mediated rejection (AMR). Currently,…2015 American Transplant Congress
Detergent-Sonication Method for the Whole Laryngeal Decellularization
Background: Each year, about 136,000 individuals worldwide are diagnosed with larynx carcinoma. Tissue engineered organs shows promising alternative to a conventional transplantation in both preclinical…
American Transplant Congress abstracts