2022 American Transplant Congress
Immune Checkpoints, Immune Cells, and MHC Expression in the Tumor Microenvironment of Resected Hepatocellular Carcinomas
*Purpose: Advances in tumor biology has shown the important role of the tumor microenvironment (TME) in tumor growth and metastasis. A better understanding of the…2022 American Transplant Congress
Specificity and Avidity of Donor MHC-Specific B Cells in Naive, Rejecting and Tolerant Mice
*Purpose: Antibody-mediated rejection is recognized as an important mediator of graft loss in the clinic, and the induction of donor-specific B cell tolerance may contribute…2021 American Transplant Congress
Human Leukocyte Antigen Mismatches Between Donor-Recipient or Donor-Donor are Not Associated with Adverse Pancreas Outcomes in Pancreas After Kidney Transplant Recipients
University of Wisconsin, MADISON, WI
*Purpose: A greater degree of HLA mismatch has been previously associated with inferior graft survival in kidney and pancreas transplantation. Pancreas after kidney (PAK) recipients…2021 American Transplant Congress
Transplant Glomerulopathy in the Absence of Donor-specific HLA Antibodies: Risk Factors, Histopathological Features and Graft Outcome
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Transplant glomerulopathy (TG) is established as a hallmark of chronic antibody-mediated rejection in kidney transplant patients with donor-specific HLA antibodies (HLA-DSA). The clinical importance…2020 American Transplant Congress
Calculated Panel Reactive Antibody Values Increase for Kidney Transplant Candidates with HLA-DQA and HLA-DPB Unacceptable Antigens
*Purpose: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. CPRA includes…2020 American Transplant Congress
Novel Role of Qa-1, a Murine Homolog of HLA-E, in Controlling Follicular Helper T Cells During Humoral Alloimmunity
*Purpose: Antibody-mediated rejection (AMR) is a major challenge in prolonging allograft survival. Limited insight into the humoral alloimmunity hinders the development of therapeutic strategies. We…2020 American Transplant Congress
Extended HLA Typing of Kidney Transplant Pairs is Necessary to Assign Presence of Donor-Specific Anti-HLA Antibodies
*Purpose: The need for extended high-resolution (HR) HLA genotyping in solid organ transplantation is currently widely debated due to higher costs and questioned clinical importance.…2020 American Transplant Congress
The Eplet-Mismatch Landscape in Kidney Patients and Deceased Donors in British Columbia
*Purpose: Minimizing quantitative donor/recipient mismatch at the HLA epitope level may optimize graft outcomes in renal transplantation, but the degree to which optimal matching can…2019 American Transplant Congress
Proteomics Reveals Compartment-Specific Alterations in the Extracellular Matrix of Kidney Allografts with Antibody-Mediated Rejection
*Purpose: Antibody-mediated rejection (AMR) is the most important cause of premature kidney graft loss. AMR is caused by anti-HLA and non-HLA antibodies against proteins in…2019 American Transplant Congress
In Vitro Model to Study the Effect of Irradiation Preconditioning on Alloimmune Responses: Development of Potential Predictive Markers
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Pre-conditioning using total body irradiation prior to HSCT is a well-established regimen for patients with hematological malignancy. However, irradiation (IR) elicits not only immunosuppressive…
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