ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Major histocompatibility complex (MHC)"

  • 2020 American Transplant Congress

    Calculated Panel Reactive Antibody Values Increase for Kidney Transplant Candidates with HLA-DQA and HLA-DPB Unacceptable Antigens

    E. P. Kransdorf1, C. Murphey2, M. Maiers3, L. Gragert4

    1Cedars-Sinai Heart Institute, Beverly Hills, CA, 2Immunogenetics Lab, Southwest Immunodiagnostics, Inc., San Antonio, TX, 3Bioinformatics Research, Be The Match/National Marrow Donor Program, Minneapolis, MN, 4Department of Pathology, Tulane University School of Medicine, New Orleans, LA

    *Purpose: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. CPRA includes…
  • 2020 American Transplant Congress

    Novel Role of Qa-1, a Murine Homolog of HLA-E, in Controlling Follicular Helper T Cells During Humoral Alloimmunity

    J. Y. Choi1, S. K. Eskandari1, S. Cai1, J. Assaker1, I. Sulkaj1, H. Allos1, J. Alhaddad1, P. Chu1, H. Kim2, H. I. Cantor2, J. R. Azzi1

    1Medicine, Brigham and Women's Hospital, Boston, MA, 2Immunology, Dana Farber Cancer Institute, Boston, MA

    *Purpose: Antibody-mediated rejection (AMR) is a major challenge in prolonging allograft survival. Limited insight into the humoral alloimmunity hinders the development of therapeutic strategies. We…
  • 2020 American Transplant Congress

    Extended HLA Typing of Kidney Transplant Pairs is Necessary to Assign Presence of Donor-Specific Anti-HLA Antibodies

    A. Senev1, V. Van Sandt2, M. Naesens1, M. Emonds1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2HILA, Rode Kruis Vlaanderen, Leuven, Belgium

    *Purpose: The need for extended high-resolution (HR) HLA genotyping in solid organ transplantation is currently widely debated due to higher costs and questioned clinical importance.…
  • 2020 American Transplant Congress

    The Eplet-Mismatch Landscape in Kidney Patients and Deceased Donors in British Columbia

    J. Tran1, O. Gunther2, J. Lan1, M. Kadatz1, R. Sapir-Pichhadze3, P. A. Keown1

    1University of British Columbia, Vancouver, BC, Canada, 2Gunther Analytics, Vancouver, BC, Canada, 3McGill University, Montreal, QC, Canada

    *Purpose: Minimizing quantitative donor/recipient mismatch at the HLA epitope level may optimize graft outcomes in renal transplantation, but the degree to which optimal matching can…
  • 2019 American Transplant Congress

    Proteomics Reveals Compartment-Specific Alterations in the Extracellular Matrix of Kidney Allografts with Antibody-Mediated Rejection

    S. Clotet Freixas1, C. McEvoy1, I. Batruch2, M. Kotlyar3, C. Pastrello3, J. Van1, A. Bozovic1, V. Kulasingam1, P. Chen4, I. Jurisica3, A. Chruscinski1, R. John1, A. Konvalinka1

    1University Health Network, Toronto, ON, Canada, 2Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada, 3Krembil Research Institute, Toronto, ON, Canada, 4Institute of Medical Science, University of Toronto, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR) is the most important cause of premature kidney graft loss. AMR is caused by anti-HLA and non-HLA antibodies against proteins in…
  • 2019 American Transplant Congress

    In Vitro Model to Study the Effect of Irradiation Preconditioning on Alloimmune Responses: Development of Potential Predictive Markers

    K. Shimozawa, K. Janec, L. Contreras-Ruiz, E. C. Guinan

    Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA

    *Purpose: Pre-conditioning using total body irradiation prior to HSCT is a well-established regimen for patients with hematological malignancy. However, irradiation (IR) elicits not only immunosuppressive…
  • 2019 American Transplant Congress

    Correlation of Crossmatch Predictions with Actual Results and Clinical Outcomes

    R. Forbes1, B. Concepcion1, S. Fossey2

    1Vanderbilt University Medical Center, Nashville, TN, 2Dialysis Clinic, Inc, Nashville, TN

    *Purpose: Flow cytometry crossmatching (FXM) is recognized as a valuable tool to assess immunological risk prior to renal transplantation. The increased resolution in HLA typing…
  • 2019 American Transplant Congress

    Epitope-Based Matching in Pediatric Kidney Transplantation

    C. Boussard1, M. Ould Rabah2, O. Boyer2, M. Macher1, J. Taupin3, J. Hogan4

    1Department of Pediatric Nephrology, Robert Debre hospital, APHP, Paris, France, 2Department of Pediatric Nephrology, Necker Enfants-Malades, APHP, Paris, France, 3Department of Immunology, Saint-Louis Hospital, APHP, Paris, France, 4Transplant Research Center, Department of Surgery, Emory University, ATLANTA, GA

    *Purpose: Following the allocation of a transplant by the allocation system, each pediatric transplant team reviews the proposal and decides based on various criteria whether…
  • 2019 American Transplant Congress

    Synergistic Effect of HLA Eplet Mismatch Load and CMV Viremia on Clinical Antibody-Mediated Rejection in Lung Transplantation

    Y. Im1, S. Yeramaneni2, Y. Yim3, J. Dodderer4, M. Askar1, H. J. Huang5

    1Baylor University Medical Center, Dallas, TX, 2Baylor Scott & White Health, Dallas, TX, 3Ross University School of Medicine, Portsmouth, Dominica, 4Texas Tech University Health Sciences Center, El Paso, TX, 5Houston Methodist Hospital, Houston, TX

    *Purpose: De novo donor specific antibodies (dnDSA) occur in up to 50% of lung transplant (LUTX) recipients within one year and are associated with increased…
  • 2019 American Transplant Congress

    Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation

    J. Y. Choi1, S. K. Eskandari1, J. Assaker1, I. Sulkaj1, S. Cai1, H. Allos1, M. Uehara1, M. Mohammad1, B. S. Al Dulaijan1, A. Bano1, E. Al Huassain1, H. I. Cantor2, J. R. Azzi1

    1Medicine, Brigham and Women's Hospital, Boston, MA, 2Dana-Farbar Caner Institute, Boston, MA

    *Purpose: HLA-E is an MHC class-1b molecule that is under-studied in the transplant setting. Recent clinical studies have revealed a robust association between allograft outcome…
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