2019 American Transplant Congress
Proteomics Reveals Compartment-Specific Alterations in the Extracellular Matrix of Kidney Allografts with Antibody-Mediated Rejection
*Purpose: Antibody-mediated rejection (AMR) is the most important cause of premature kidney graft loss. AMR is caused by anti-HLA and non-HLA antibodies against proteins in…2019 American Transplant Congress
In Vitro Model to Study the Effect of Irradiation Preconditioning on Alloimmune Responses: Development of Potential Predictive Markers
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Pre-conditioning using total body irradiation prior to HSCT is a well-established regimen for patients with hematological malignancy. However, irradiation (IR) elicits not only immunosuppressive…2019 American Transplant Congress
Correlation of Crossmatch Predictions with Actual Results and Clinical Outcomes
1Vanderbilt University Medical Center, Nashville, TN, 2Dialysis Clinic, Inc, Nashville, TN
*Purpose: Flow cytometry crossmatching (FXM) is recognized as a valuable tool to assess immunological risk prior to renal transplantation. The increased resolution in HLA typing…2019 American Transplant Congress
Epitope-Based Matching in Pediatric Kidney Transplantation
*Purpose: Following the allocation of a transplant by the allocation system, each pediatric transplant team reviews the proposal and decides based on various criteria whether…2019 American Transplant Congress
Synergistic Effect of HLA Eplet Mismatch Load and CMV Viremia on Clinical Antibody-Mediated Rejection in Lung Transplantation
*Purpose: De novo donor specific antibodies (dnDSA) occur in up to 50% of lung transplant (LUTX) recipients within one year and are associated with increased…2019 American Transplant Congress
Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation
1Medicine, Brigham and Women's Hospital, Boston, MA, 2Dana-Farbar Caner Institute, Boston, MA
*Purpose: HLA-E is an MHC class-1b molecule that is under-studied in the transplant setting. Recent clinical studies have revealed a robust association between allograft outcome…2019 American Transplant Congress
MHC Cross-Dressing in Mixed Hematopoietic Chimerism
*Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…2018 American Transplant Congress
HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation
Permanent hypoparathyroidism(PH) is incurable condition and requires life long drug therapy.Unique therapeutic option is parathyroid allotransplantation(PA).Some studies use routinely but emprically HLA typing,PRA(panel reactive antibody)…2018 American Transplant Congress
MICA/B Polymorphisms and the Relationship of the Matching Degree between MICA/B and HLA of Related Donor-Recipient Pairs in Allo-HSCT
Beijing 307 Hospital, Beijing, China.
Objective: To explore the distribution characteristics of MICA/B gene polymorphism in the Han Chinese and the relationship of the matching degree between MICA/MICB and HLA…2018 American Transplant Congress
Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
Monocytes distinguish between self and allogeneic non-self and contribute to allograft rejection by generating mature, IL-12+, DCs. The initial trigger of monocyte differentiation to DCs…