Session Name: Poster Session C: Histocompatibility and Immunogenetics
Date: Monday, June 4, 2018
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Permanent hypoparathyroidism(PH) is incurable condition and requires life long drug therapy.Unique therapeutic option is parathyroid allotransplantation(PA).Some studies use routinely but emprically HLA typing,PRA(panel reactive antibody) and DSA(donor specific antigen) screening tests before PA.In this research we aimed to evaluate the effectiveness of HLA,PRA and DSA for success of PA.We performed PA to unrelated four recipients from one living donor.HLA typing,PRA and DSA levels were observed.Recipients were discharged from the hospital without any complications and observed throughout four years.Two out of four PAs were successful.No correlations were observed for the success of transplantation about the tests of HLA typing,PRA and DSA(Table 1).In conclusion HLA typing,PRA and DSA tests were not necessary for PA.
Table 1. Comparision of pre-/post-transplant results. Rcp:Recipient
|Donor||A*26 /A*32||B*14 /B*44||C*05 / C*08||B1*01 /B1*04||B1*03 / B1*05|
|Rcp 1||A*11 /A*24||B*44 /B*51||C*04 / C*07||B1*13 /B1*13||B1*06 / B1*06|
|Rcp 2||A*02 /A*68||B*18 / B*51||C*07 / C*15||B1*11 /B1*11||B1*03 / B1*03|
|Rcp 3||A*01 /A*32||B*08 / B*57||C*06 / C*07||B1*03 /B1*03||B1*02 / B1*02|
|Rcp 4||A*02 /A*02||B*51 / B*51||C*07 / C*15||B1*11 /B1*16||B1*03 / B1*05|
CITATION INFORMATION: Kanimdan E., Goncu B., Gelmez Y., Idiz O., Toka C., Ozdemir B., Basoglu H., Ozten Kandas N., Yucesan E., Ersoy Y., Kazancioglu R., Aysen E. HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Kanimdan E, Goncu B, Gelmez Y, Idiz O, Toka C, Ozdemir B, Basoglu H, Kandas NOzten, Yucesan E, Ersoy Y, Kazancioglu R, Aysen E. HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation [abstract]. https://atcmeetingabstracts.com/abstract/hla-typing-panel-reactive-antibody-and-donor-specific-antigen-tests-are-not-necessary-for-successful-parathyroid-allotransplantation/. Accessed September 18, 2021.
« Back to 2018 American Transplant Congress