Articles tagged "Major histocompatibility complex (MHC)"

2019 American Transplant Congress
Proteomics Reveals Compartment-Specific Alterations in the Extracellular Matrix of Kidney Allografts with Antibody-Mediated Rejection
S. Clotet Freixas¹, C. McEvoy¹, I. Batruch², M. Kotlyar³, C. Pastrello³, J. Van¹, A. Bozovic¹, V. Kulasingam¹, P. Chen⁴, I. Jurisica³, A. Chruscinski¹, R. John¹, A. Konvalinka¹
¹University Health Network, Toronto, ON, Canada, ²Lunenfeld-Tanenbaum Research Institute, Toronto, ON, Canada, ³Krembil Research Institute, Toronto, ON, Canada, ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada
*Purpose: Antibody-mediated rejection (AMR) is the most important cause of premature kidney graft loss. AMR is caused by anti-HLA and non-HLA antibodies against proteins in…
2019 American Transplant Congress
In Vitro Model to Study the Effect of Irradiation Preconditioning on Alloimmune Responses: Development of Potential Predictive Markers
K. Shimozawa, K. Janec, L. Contreras-Ruiz, E. C. Guinan
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Pre-conditioning using total body irradiation prior to HSCT is a well-established regimen for patients with hematological malignancy. However, irradiation (IR) elicits not only immunosuppressive…
2019 American Transplant Congress
Correlation of Crossmatch Predictions with Actual Results and Clinical Outcomes
R. Forbes¹, B. Concepcion¹, S. Fossey²
¹Vanderbilt University Medical Center, Nashville, TN, ²Dialysis Clinic, Inc, Nashville, TN
*Purpose: Flow cytometry crossmatching (FXM) is recognized as a valuable tool to assess immunological risk prior to renal transplantation. The increased resolution in HLA typing…
2019 American Transplant Congress
Epitope-Based Matching in Pediatric Kidney Transplantation
C. Boussard¹, M. Ould Rabah², O. Boyer², M. Macher¹, J. Taupin³, J. Hogan⁴
¹Department of Pediatric Nephrology, Robert Debre hospital, APHP, Paris, France, ²Department of Pediatric Nephrology, Necker Enfants-Malades, APHP, Paris, France, ³Department of Immunology, Saint-Louis Hospital, APHP, Paris, France, ⁴Transplant Research Center, Department of Surgery, Emory University, ATLANTA, GA
*Purpose: Following the allocation of a transplant by the allocation system, each pediatric transplant team reviews the proposal and decides based on various criteria whether…
2019 American Transplant Congress
Synergistic Effect of HLA Eplet Mismatch Load and CMV Viremia on Clinical Antibody-Mediated Rejection in Lung Transplantation
Y. Im¹, S. Yeramaneni², Y. Yim³, J. Dodderer⁴, M. Askar¹, H. J. Huang⁵
¹Baylor University Medical Center, Dallas, TX, ²Baylor Scott & White Health, Dallas, TX, ³Ross University School of Medicine, Portsmouth, Dominica, ⁴Texas Tech University Health Sciences Center, El Paso, TX, ⁵Houston Methodist Hospital, Houston, TX
*Purpose: De novo donor specific antibodies (dnDSA) occur in up to 50% of lung transplant (LUTX) recipients within one year and are associated with increased…
2019 American Transplant Congress
Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation
J. Y. Choi¹, S. K. Eskandari¹, J. Assaker¹, I. Sulkaj¹, S. Cai¹, H. Allos¹, M. Uehara¹, M. Mohammad¹, B. S. Al Dulaijan¹, A. Bano¹, E. Al Huassain¹, H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Dana-Farbar Caner Institute, Boston, MA
*Purpose: HLA-E is an MHC class-1b molecule that is under-studied in the transplant setting. Recent clinical studies have revealed a robust association between allograft outcome…
2019 American Transplant Congress
MHC Cross-Dressing in Mixed Hematopoietic Chimerism
B. Gonzalez Nolasco¹, M. Wang¹, W. Orent¹, A. Prunevieille¹, K. Pruner¹, J. O¹, J. Paster¹, J. C. Madsen², G. Benichou¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Achieving specific long-term allograft survival without ongoing immunosuppression is one of the main objectives in transplantation. Mixed hematopoietic chimerism is a strategy that has…
2018 American Transplant Congress
HLA Typing, Panel Reactive Antibody and Donor Specific Antigen Tests Are Not Necessary for Successful Parathyroid Allotransplantation
E. Kanimdan,¹ B. Goncu,² Y. Gelmez,³ O. Idiz,⁴ C. Toka,⁵ B. Ozdemir,² H. Basoglu,⁶ N. Ozten Kandas,⁷ E. Yucesan,⁸ Y. Ersoy,⁵ R. Kazancioglu,⁹ E. Aysen.⁵
¹Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; ²Bezmialem Vakif University, Experimental Research Center, Istanbul, Turkey; ³Istanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Immunology, Istanbul, Turkey; ⁴Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey; ⁵Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey; ⁶Bezmialem Vakif University, Faculty of Medicine, Department of Biophysics, Istanbul, Turkey; ⁷Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey; ⁸Bezmialem Vakif University, Institute of Life Sciences and Biotechnology, Istanbul, Turkey; ⁹Bezmialem Vakif University, Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey.
Permanent hypoparathyroidism(PH) is incurable condition and requires life long drug therapy.Unique therapeutic option is parathyroid allotransplantation(PA).Some studies use routinely but emprically HLA typing,PRA(panel reactive antibody)…
2018 American Transplant Congress
MICA/B Polymorphisms and the Relationship of the Matching Degree between MICA/B and HLA of Related Donor-Recipient Pairs in Allo-HSCT
Y. Sun, Y. Hao, J. Jin, L. Ding, F. Liang, N. Liu, J. Long, X. Zhao, Y. Xi.
Beijing 307 Hospital, Beijing, China.
Objective: To explore the distribution characteristics of MICA/B gene polymorphism in the Han Chinese and the relationship of the matching degree between MICA/MICB and HLA…
2018 American Transplant Congress
Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
H. Dai,¹ P. Lan,² A. Friday,¹ A. Williams,¹ M. Oberbarnscheidt,¹ X. Li,² F. Lakkis.¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA; ²Immunobiology, Houston Methodist Hospital, Houston, TX.
Monocytes distinguish between self and allogeneic non-self and contribute to allograft rejection by generating mature, IL-12+, DCs. The initial trigger of monocyte differentiation to DCs…