2019 American Transplant Congress
Protective Effect of Ischemic-Free Liver Transplantation Technique on Distant Multiple Organ Function
*Purpose: Hypothermia, hypoxia and ischemia-reperfusion injury (IRI) in standard liver transplantation (SLT) are the main factors that affect graft function and cause damage to remote…2019 American Transplant Congress
Oxygenated Hypothermic Machine Perfusion of Kidneys Donated after Circulatory Death: An International Randomised Controlled Trial
*Purpose: An international, double-blinded, randomised, paired phase 3 trial designed to determine the effect on 1-year graft function of continuous oxygenated (HMPO) vs non-oxygenated hypothermic…2019 American Transplant Congress
Effectiveness Of The Vittal Viability Criteria During Ex Situ Normothermic Machine Perfusion To Discriminate Hepatobiliary Organ Injury And Investigation Of Biochemical Markers For Post-transplant Complications
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
*Purpose: The VITTAL (viability testing and transplantation of marginal livers) clinical trial demonstrated that ex situ end-ischaemic normothermic machine perfusion (NMP) allows functional assessment and…2019 American Transplant Congress
Combined Thoracic-Liver Transplants Using Normothermic Machine Perfusion for Liver Preservation: A Case Series
Henry Ford Transplant Institute, Detroit, MI
*Purpose: There is minimal data describing combined thoracic-liver transplants (tx) with normothermic machine perfusion (NMP) used for liver preservation as the thoracic tx is done.…2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes
*Purpose: Donor organ shortage has led to increased reliance on high-risk livers for transplantation. Furthermore, emergence of machine perfusion has led to a paradigm shift…2019 American Transplant Congress
Long Term Cold Ischemia Time in Kidney Transplantation. The Role of Hypothermic Machine Perfusion
*Purpose: Hypothermic machine perfusion (HMP) of deceased donor kidneys is associated with a better outcome than static cold storage (SCS). Aim of this prospective study…2019 American Transplant Congress
Prevention of Graft Ischemia-Reperfusion Injury in Ischemia-Free Liver Transplantation
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Graft ischemia-reperfusion injury (IRI) is an inevitable event in organ transplantation, which often leads to a number of complications and even patient deaths. We…2019 American Transplant Congress
Hypothermic Machine Perfusion Protects Donation After Cardiac Deathliver Graft Through Gstm1-mediated Cytochrome P450 Exogenous Substance Metabolism Pathway
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases, Wuhan, China
*Purpose: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…2019 American Transplant Congress
Sirna Uptake During Ex Vivo Hypothermic And Normothermic Liver Machine Perfusion: Beginning Of A New Era Of Organ Preservation
*Purpose: RNA interference (RNAi) is a natural gene modulation process that was recently approved for clinical use and has great potential for treatment of many…2019 American Transplant Congress
Normothermic Machine Perfusion of Human Kidneys without an Oxygen Carrier
Massachusetts General Hospital, Boston, MA
*Purpose: Normothermic machine perfusion (NMP) is a promising strategy for pre-transplant reconditioning and viability assessment of marginal renal grafts. All current clinical kidney NMP protocols…
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