Articles tagged "Lung"

2021 American Transplant Congress
Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung Preservation
L. M. Radomsky¹, A. Koch², C. Olbertz², J. F. Kuehne¹, Y. Liu², J. Keil¹, K. Beushausen¹, U. Rauen³, C. S. Falk¹, M. Kamler²
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Thoracic Transplantation, Department of Thoracic and Cardiovascular Surgery, University Hospital Essen, Essen, Germany, ³Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany
*Purpose: Ex vivo lung perfusion is an innovative technique to evaluate marginal lung organs especially after DCD. Normothermic continuous perfusion should reduce ischemic damage and…
2021 American Transplant Congress
Evaluation of Meningococcal Vaccine Response Among Solid Organ Transplant Recipients Receiving Eculizumab
R. Arora¹, C. Kane¹, K. Cunningham¹, M. Ison²
¹Pharmacy, Northwestern Memorial Hospital, Chicago, IL, ²Divisions of Infectious Diseases and Organ Transplantation, Northwestern Memorial Hospital, Chicago, IL
*Purpose: Patients receiving eculizumab are at a 1,000-2,000-fold increased risk of invasive meningococcal infections. Therefore, the Advisory Committee for Immunization Practices recommends that these patients…
2021 American Transplant Congress
Donor-Derived Tuberculosis in Lung Transplant Recipients, a Single Center Experience
M. Robbins, D. Kabbani, C. Cervera, C. O'Neil, R. Cooper, K. Halloran, S. Grocholski, K. Doucette
University of Alberta, Edmonton, AB, Canada
*Purpose: Donor-derived (DD) tuberculosis (TB) in solid-organ transplantation (SOT) is rare with the largest review to date identifying only 25 cases of proven or probable…
2021 American Transplant Congress
Impact of Positive Donor Cultures on Postoperative Lung Transplantation Infectious Outcomes
A. Curtis, C. Pham, B. P. Pierce
Houston Methodist Hospital, Houston, TX
*Purpose: Transmission risk of microbes present in donor lungs at time of donation to lung transplant recipients (LTR) is unclear. Infection is the second highest…
2020 American Transplant Congress
Ambient Air Pollution and Waitlist Mortality among Lung Transplant Candidates
Y. Feng¹, M. R. Jones², N. Chu¹, D. Segev¹, M. McAdams-DeMarco¹
¹Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²Department Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
*Purpose: Previous studies suggested that air pollution is associate with higher risk of respiratory diseases and accelerated decline in lung function among general population. However,…
2020 American Transplant Congress
Case Series of Belatacept for Calcineurin Inhibitor Sparing after Lung Transplantation
H. Patel, C. R. Ensor, R. D. Davis, L. Bogar, D. Colella, M. Kildea, J. Kim, A. Satterthwaite, D. Ventura, C. Gries
AdventHealth, Orlando, FL
*Purpose: Belatacept is a recombinant soluble fusion protein which selectively blocks T-cell co-stimulation. It received initial FDA approval for prophylaxis of organ rejection in Epstein-Barr…
2020 American Transplant Congress
Impact of Ozone Exposure of Lung Donors and Recipients on All-Cause Mortality after Lung Transplant
T. Egan¹, S. Arunachalam², C. Chang², P. Strassle¹
¹Surgery, UNC at Chapel Hill, Chapel Hill, NC, ²Institute of the Environment, UNC at Chapel Hill, Chapel Hill, NC
*Purpose: A Belgian study found proximity to a motorway increased risk of bronchiolitis obliterans syndrome after lung transplant (LT). Using zip codes as a surrogate…
2020 American Transplant Congress
First Report of Successful CD38-Antagonist Daratumumab Augmented Carfilzomib-Based Treatment of Refractory Definite AMR of the Lung Allograft
M. N. Kildea¹, C. R. Ensor¹, J. Kim¹, L. Bogar¹, D. Colella¹, R. D. Davis¹, M. Marschner¹, A. Zeevi², N. Soe¹, C. Gries¹
¹AdventHealth, Orlando, FL, ²University of Pittsburgh, Pittsburgh, PA
*Purpose: Antibody-mediated rejection (AMR) after lung transplant (LT) is associated with early progressive chronic lung allograft dysfunction (CLAD) and death. Therapeutic regimens remain poorly evaluated.…
2020 American Transplant Congress
Effectiveness of Routine Screening for Mycoplasma Hominis and Ureaplasma spp. in Lung Transplant Recipients
P. Vijayvargiya, Z. Esquer Garrigos, C. C. Kennedy, R. C. Daly, M. E. Wylam, E. Beam
Mayo Clinic, Rochester, MN
*Purpose: In lung transplant recipients Mycoplasma hominis and Ureaplasma spp. may cause localized or disseminated infection and fatal hyperammonemia syndrome (HS). Optimal prevention strategies are…
2020 American Transplant Congress
Impact of Pretransplant Malignancy on Heart and Lung Transplant Recipients
W. Kang¹, C. T. Sparrow², M. Kim¹, M. Rachid³, S. M. Soriano³
¹Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, ²Department of Cardiology, University of Illinois College of Medicine at Peoria, Peoria, IL, ³Department of Pulmonology, University of Illinois College of Medicine at Peoria, Peoria, IL
*Purpose: The purpose of this study is to investigate pre-transplant malignancy (PTM) as a risk factor for worsened post-transplant prognosis in heart or lung transplant…