2021 American Transplant Congress
Impact of Lung Allocation Score Cohort Update
1SRTR, Minneapolis, MN, 2Univ of Washington, Seattle, WA, 3Cleveland Clinic, Cleveland, OH
*Purpose: The lung allocation score (LAS) was last revised in February, 2015, based on waitlist (WL) and posttransplant (PT) survival model cohorts from 2006-2008 and…2021 American Transplant Congress
Polyomavirus BK-Associated Nephropathy in Patients After Renal and Extrarenal Transplantation
*Purpose: Patients with non-renal organ transplantation (TX) may suffer BK-viral nephropathy (BKVN) of their own orthotopic kidneys. We aimed to know if these patients with…2021 American Transplant Congress
A Retrospective Analysis of the Safety and Efficacy of Apixaban After Lung Transplant
*Purpose: Atrial arrhythmias and venous thromboembolism (VTE) are common after lung transplant. While direct acting oral anticoagulants (DOACs) have become anticoagulants of choice in atrial…2021 American Transplant Congress
Liver Kinase B1 Knockdown Induces Platelet-Derived Growth Factor Receptor B Expression in Human Airway Epithelial Cells: A Potential Mechanism for Development of Fibrosis Leading to Chronic Lung Allograft Dysfunction
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The platelet-derived growth factor and its receptor (PDGFRb) signaling pathway can be activated by epithelial mesenchymal transition which facilitates fibrosis. It is not known…2021 American Transplant Congress
Evaluating Pneumocystis Jiroveci Pneumonia Prophylaxis in Lung Transplant Recipients
Michigan Medicine, Ann Arbor, MI
*Purpose: The incidence of Pneumocystis jiroveci pneumonia (PJP) in lung transplant recipients (LTRs) on PJP prophylaxis is not well documented yet reported as high as…2021 American Transplant Congress
BK Virus-associated Nephropathy as a Cause of Renal Failure Post-lung Transplantation
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: BK virus-associated nephropathy (BKVAN) is a common cause of renal dysfunction early after renal transplant. BKVAN is much rarer in non-renal solid organ transplant,…2021 American Transplant Congress
Pathology of the Explanted Lungs and Surveillance Allograft Biopsy in 202 Lung Transplant Cases: Single Institution Experience
*Purpose: This study correlates lung transplantation outcomes with pathologic diagnoses of explants and surveillance transbronchial allograft biopsies.*Methods: A retrospective IRB approved review of archival material…2021 American Transplant Congress
Allograft Discard Risk Index for Lung Transplantation
Baylor College of Medicine, Houston, TX
*Purpose: The demand for donor lungs continues to outpace the supply, yet nearly 80% of donor lungs consented for lung transplantation (LTx) are discarded.*Methods: We…2021 American Transplant Congress
Accelerated Bronchiolitis Obliterans After Lung Transplant Promoted by an ATG16L1 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-derived Antigen Presenting Cells
1Washington University, Saint Louis, MO, 2UT Southwestern Medical Center, Dallas, TX
*Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood. It is…2021 American Transplant Congress
Antibody-mediated Rejection and Sponge Effect in a Redo Lung Transplant Recipient: A Case Report
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: Antibody-mediated rejection (AMR) typically presents with elevated titers of circulating donor specific antibodies (DSA) and increased mean fluorescence intensity (MFI), a surrogate marker for…
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