2022 American Transplant Congress
Immunomodulation in Lung Transplant May Facilitate Transformation of Usual Interstitial Pneumonia Into Pleuroparenchymal Fibroelastosis
*Purpose: Pleuroparenchymal fibroelastosis (PPFE) is a rare but distinctive manifestation of interstitial lung disease (ILD) characterized by a highly elastotic pattern of lung fibrosis. Its…2022 American Transplant Congress
B and Plasma Cell Populations Drive Chronic Rejection After Lung Transplantation
*Purpose: Chronic lung allograft dysfunction (CLAD) remains the major determinant of morbidity and mortality post-lung transplantation (LTx). Bronchiolitis obliterans syndrome (BOS) is the most prevalent…2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…2022 American Transplant Congress
Lung Transplant Waitlist Outcomes for Blood Group O Candidates After the Expansion of the Primary Allocation Unit in November 2017
*Purpose: Blood group O is associated with decreased lung transplant rates. Occasionally, blood group donor O lungs are allocated to non-blood group O recipients. Since…2022 American Transplant Congress
Emphysematous Cystitis in a Lung Transplant Recipient with BK Viremia
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: Emphysematous cystitis (EC) is a rare urinary tract infection from E. coli or K. pneumoniae in diabetics or immunocompromised individuals, resulting in sepsis and…2022 American Transplant Congress
Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection
*Purpose: Bronchiolitis obliterans syndrome (BOS) remains a major cause of death after lung transplantation. Unfortunately, we lack effective treatments for BOS as the mechanisms by…2022 American Transplant Congress
Impact Of Antifungal Prophylaxis Discontinuation On Immunosuppression In Lung Transplant Recipients
Pharmacy, Cleveland Clinic, Cleveland, OH
*Purpose: The purpose of this study is to characterize the impact of antifungal discontinuation on immunosuppressant levels and incidence of acute rejection and fungal infections…2022 American Transplant Congress
Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor
UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Primary immunodeficiency (PID) patients may develop pulmonary complications, and most are ineligible for either BOLT or BMT due to futility. A prospective trial in…2022 American Transplant Congress
Spectrum of Pre-Transplant Esophagram Abnormalities and Association with Long-Term Outcomes
*Purpose: To determine the frequency and type of esophageal abnormalities on screening esophagram during the pre-transplant evaluation and evaluate the association of these abnormalities on…2022 American Transplant Congress
High TTV Load Before First Vaccine Dose is Associated with Poor Serological Response to Covid-19 Vaccination in Lung Transplant Recipients
*Purpose: Torque tenovirus (TTV), a highly prevalent virus which is not known to cause pathology in humans, is currently being investigated as a marker of…
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