Articles tagged "Lung transplantation"

2018 American Transplant Congress
Simultaneous Persistence and Development of Donor and Recipient Tissue Resident Memory T Cells in Lung Transplantation
M. Snyder,¹ T. Connors,² C. Marboe,³ L. Benvenuto,¹ L. Shah,¹ H. Robbins,¹ J. Hook,¹ F. D'Ovidio,⁴ M. Bacchetta,⁴ J. Sonnett,⁴ S. Arcasoy,¹ D. Farber.^4,5
¹Medicine, Columbia University Medical Center, New York, NY; ²Pediatrics, Columbia University Medical Center, New York, NY; ³Pathology, Columbia University Medical Center, New York, NY; ⁴Surgery, Columbia University Medical Center, New York, NY; ⁵Microbiology & Immunology, Columbia University Medical Center, New York, NY.
Introduction: The predominant T cell population in the lung comprises non-circulating tissue-resident memory T cells (TRM); however, the fate of these cells in transplanted lung…
2018 American Transplant Congress
Superiority of Early Everolimus-Based Quadruple Immunosuppression versus Standard Triple Therapy after Lung Transplantation: 12 Months Results from Prospective 4EVERLUNG Study in Germany
J. Gottlieb, C. Neurohr, J. Müller-Quernheim, H. Wirtz, B. Sill, H. Wilkens, V. Besa, C. Knosalla, M. Junge, C. Capusan, M. Strüber.
Klinik, Hannover, Germany; Klinik, München, Germany; Klinik, Freiburg, Germany; Klinik, Leipzig, Germany; Klinik, Hamburg, Germany; Klinik, Homburg, Germany; Klinik, Essen, Germany; Klinik, Berlin, Germany; Novartis Pharma, Nürnberg, Germany; Novartis Pharma, Nürnberg, Germany; Klinik, Hannover, Germany.
The 4Everlung trial was designed to evaluate the benefit of early everolimus (EVR)-based quadruple low immunosuppressive (IS) regimen on kidney function (RF) after LTx.4EVERLUNG is…
2018 American Transplant Congress
Identification of Exosomal Proteins from Human Lung Transplant Recipients
S. Bansal,¹ P. Pirrotte,² M. Saltzman,² K. Garcia,² M. Sharma,¹ M. Gunasekaran,¹ M. Smith,¹ R. Bremner,¹ T. Mohanakumar.¹
¹Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix; ²Collaborative Center for Translational Mass Spectrophotometry Translational Genomics Research Institute, Phoenix.
Molecular mechanisms involved in rejection following human lung transplantation are not well understood. Goal of this study is to identify proteomic signatures in the circulating…
2018 American Transplant Congress
Ultrastructural Changes in Lung Allografts: Endothelial Changes Correlate with Donor Specific Antibody & Antibody Mediated Rejection
M. Alexander, A. Bentall, P. Abell Aleff, J. Scott, A. Roden.
Mayo Clinic, Rochester, MN.
Introduction: Antibody mediated rejection (AMR) causes lung allograft (LA) injury. Challenges with C4d interpretation & lack of specific histological criteria account for difficulty in diagnosing…
2018 American Transplant Congress
Nontuberculous Mycobacteria in Lung Transplant Recipients: Prevalence, Risk Factors and Impact on Survival and Graft Function
D. Friedman, C. Cervera, K. Halloran, G. Tyrrell, K. Doucette.
University of Alberta, Edmonton, Canada.
BACKGROUND. Nontuberculous mycobacteria (NTM) may colonize or infect lung transplant patients. Due to differences in populations studied and geographical diversity of NTM, risk factors for…
2018 American Transplant Congress
Impact of Changes to the LAS Calculation
R. Lehman,¹ R. Carrico,¹ K. Uccellini,¹ K. Chan,² T. Whelan.³
¹United Network for Organ Sharing, Richmond, VA; ²Univ of Michigan, Ann Arbor, MI; ³Medical Univ of South Carolina, Charleston, SC.
Purpose: On 2/19/2015 major revisions to the Lung Allocation Score (LAS) calculation were made to more appropriately reflect candidates' waiting list urgency and post-transplant survival.…
2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
K. Freischlag,¹ B. Ezekian,¹ P. Schroder,¹ J. Everitt,¹ J. Yoon,¹ M. Swiderska-Syn,³ W. Parker,¹ A. Diehl,¹ J. Kwun,¹ S. Knechtle.¹
¹Duke Transplant Center, Duke University, Durham, NC; ²Medical University of South Carolina, Charleston, SC.
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
2018 American Transplant Congress
Evaluation of Immunosuppression and Infection after Desensitization in Lung Transplantation
S. Hammad, B. Ravichandran, J. Kim, D. KuKuruga, S. Cipriano, Z. Kon.
University of Maryland Medical Center, Baltimore.
Purpose: To reduce waitlist time for sensitized lung transplant recipients (LTR), our center used peri-operative desensitization for LTR with a positive virtual crossmatch (P-VXM). We…
2018 American Transplant Congress
Colistin (COL) in Solid Organ Transplant Recipients (SOTR): Friend or Foe?
K. Neyra, C. Huauya Leuyacc, C. Kovacs, V. Athans, E. Cober.
Cleveland Clinic, Cleveland, OH.
Background: Data on COL use in SOTR are lacking. In other populations, high dose (HD) COL (>4.4mg/kg/day) has been associated with clinical and microbiologic cure…
2018 American Transplant Congress
Molecular Phenotypes of Injury and Rejection in Lung Transplant Transbronchial Biopsies
M. Parkes, K. Halloran, K. Famulski, P. Halloran, The INTERLUNG Study Group.
University of Alberta, Edmonton, Canada.
Purpose: Histologic assessment of lung transplant transbronchial biopsies (TBB) is not reproducible and cannot assess antibody-mediated rejection (ABMR). Molecular diagnostics (MMDx) successfully identified rejection in…