2018 American Transplant Congress
Disparate Risk Factors for Early and Late Death Impact Survival after Lung Transplant
Cleveland Clinic, Cleveland, OH.
Purpose: After implementation of the lung allocation score, there has been improvement in one- and three-year survival but not in five-year survival after lung transplant…2018 American Transplant Congress
T-bet and STAT6 Double Deficiency Favors IL-17 Immunity after Lung Transplantation
Background: The long-term success of lung transplantation is mainly limited by the development of obliterative bronchiolitis (OB) in which IL-17 plays a critical role. Direct…2018 American Transplant Congress
Vendor-Specific Differences in Identical Strains of Mice Yield Dichotomous Result in Lung Allograft Rejection
Intro: Orthotropic transplantation of murine lung allografts has paved the way for mechanistic studies of pulmonary tolerance and rejection but discrepancies have been reported by…2018 American Transplant Congress
Prevalence and Persistence of Cardiovascular Risk Factors and Subclinical Vascular Damage in Patients after Pediatric Lung Transplantation
In adults undergoing solid organ transplantation, cardiovascular (CV) disease causes a high level of morbidity and mortality. Children after lung transplantation (Lu-Tx) are prone to…2018 American Transplant Congress
Therapeutic Drug Monitoring (TDM) of Suspension (SUS), Extended-Release (ER), and Intravenous (IV) Posaconazole (POS) at a Large Transplant Center
Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA.
Background: Data on ER and IV POS among organ transplant recipients (OTRs) are limited, and the role of TDM is unclear.Methods: Retrospective study of patients…2018 American Transplant Congress
Organ-Specific Differences in a Thymoglobulin and Belatacept-Based Protocol for Tolerance Induction in Non-Human Primates
Massachusetts General Hospital, Boston.
In non-human primate lung transplantation, allograft acceptance has been achieved using a delayed mixed-chimerism approach consisting of 4 months of triple-drug immunosuppression followed by donor…2018 American Transplant Congress
Mycoplasma hominis Infection in Lung Transplant Recipients: A Retrospective Case Series
1UHN, Toronto, ON, Canada; 2University of Toronto, Toronto, ON, Canada; 3UC-San Diego, San Diego.
Background: Mycoplasma hominis is increasingly recognized as a respiratory pathogen causing invasive disease in solid organ transplant (SOT) recipients. We reviewed the clinical characteristics, management…2018 American Transplant Congress
Risk Factors for Invasive Fungal Infections among Lung Transplant Recipients
University of Pennsylvania, Philadelphia, PA.
Objective: Lung transplant (LT) recipients are at high risk of invasive fungal infections (IFI) with an estimated 1-year incidence of 8%. Despite advances in antifungal…2018 American Transplant Congress
Developing a Rationale for an Appropriate Immunosuppressive Regimen in Lung vs Kidney Transplant Recipients: Effects of Induction Therapy
IntroductionThe appropriate use of Thymoglobulin (ATG) or Basiliximab as induction therapy is not fully understood. We studied circulating cytokine profiles following kidney and lung transplantation…2018 American Transplant Congress
Itraconazole Prophylaxis, Trough Concentration, and Identification of Fungal Pathogens in Lung Transplant
Cleveland Clinic Foundation, Cleveland, OH.
Studies of prophylactic itraconazole (ITR) in lung transplant recipients (LTR) are lacking. Our purpose was to evaluate LTR who received ITR prophylaxis and the association…
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