2018 American Transplant Congress
Impact of Changes to the LAS Calculation
Purpose: On 2/19/2015 major revisions to the Lung Allocation Score (LAS) calculation were made to more appropriately reflect candidates' waiting list urgency and post-transplant survival.…2018 American Transplant Congress
Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts
Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…2018 American Transplant Congress
Evaluation of Immunosuppression and Infection after Desensitization in Lung Transplantation
University of Maryland Medical Center, Baltimore.
Purpose: To reduce waitlist time for sensitized lung transplant recipients (LTR), our center used peri-operative desensitization for LTR with a positive virtual crossmatch (P-VXM). We…2018 American Transplant Congress
Colistin (COL) in Solid Organ Transplant Recipients (SOTR): Friend or Foe?
Cleveland Clinic, Cleveland, OH.
Background: Data on COL use in SOTR are lacking. In other populations, high dose (HD) COL (>4.4mg/kg/day) has been associated with clinical and microbiologic cure…2018 American Transplant Congress
Molecular Phenotypes of Injury and Rejection in Lung Transplant Transbronchial Biopsies
University of Alberta, Edmonton, Canada.
Purpose: Histologic assessment of lung transplant transbronchial biopsies (TBB) is not reproducible and cannot assess antibody-mediated rejection (ABMR). Molecular diagnostics (MMDx) successfully identified rejection in…2018 American Transplant Congress
A Novel Preservation Solution for Lung That Improves Cell Viability and Tissue Architecture
1Tulane University, New Orleans; 2MUSC, Charleston.
Backgroud: Only 20% of donor lungs are used for transplant and 10 y survival of recipients is low. Many patients die within 30 d of…2018 American Transplant Congress
High Body Mass Index in Organ Donor is Significantly Correlated to Low PaO2/FiO2 Ratio in SRTR Database
Background:Atelectasis is a major cause of hypoxemia in organ donors. However, the risk factors of hypoxemia unknown. Our previous study suggested that donors with high…2018 American Transplant Congress
In Vitro Evaluation of Antibiotic Persistence in Pseudomonas aeruginosa and Staphylococcus aureus Isolates from Cystic Fibrosis Patients
UW Hospital & Clinics, Madison; UW School of Pharmacy, Madison.
Purpose: The mechanisms of antibiotic persistence in immunosuppressed populations are not fully understood. Patients with cystic fibrosis (CF), both the pre-transplant and post-transplant phase often…2018 American Transplant Congress
EVLP on Donor Lungs: National Trends and Outcomes
Purpose: The OPTN/UNOS added fields to the deceased donor registration form on 3/31/2015 to capture the intent to utilize ex vivo lung perfusion (EVLP) on…2018 American Transplant Congress
Ex Vivo Lung Perfusion Using the Portable OCS Maintains Endothelial Integrity in the Context of Reduced Severe PGD Rates
PurposeThe INSPIRE trial revealed significant reduction of PGD grade 3, i.e. less ischemia reperfusion injury (IRI) using the Organ Care System (OCS) compared to controls…
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