Articles tagged "Lung transplantation"

2018 American Transplant Congress
Time and Perfusate Dependent Molecular Response in Ex Vivo Lung Perfusion
P. Dromparis,¹ N. Aboelnazar,² S. Wagner,¹ S. Himmat,² C. White,² J. Luc,² D. Freed,² J. Nagendran,² M. Mengel,¹ B. Adam.¹
¹Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada; ²Department of Surgery (Cardiac), University of Alberta, Edmonton, Canada.
Lung transplantation has limited organ utilization and high rates of primary graft dysfunction, in part due to acute lung injury (ALI). Cold static preservation (CSP)…
2018 American Transplant Congress
The Aggressive Phenotype: Center-Level Characteristics in the Use of Suboptimal Lungs
M. Kosztowski, E. Bush, X. Luo, A. Thomas, M. Bowring, D. Segev, J. Garonzik Wang.
Johns Hopkins, Baltimore, MD.
The disparity between organ supply and demand has led some centers to expand their criteria for donor selection. We explored utilization of suboptimal lungs to…
2018 American Transplant Congress
Risk Factors for Postoperative Bleeding after Lung Transplantation
D. Adelmann,^1,2 S. Koch,¹ J. Menger,¹ P. Jaksch,³ M. Kurz,¹ M. Mouhieddine,¹ W. Klepetko,³ B. Steinlechner.¹
¹Department of Anesthesia, General Intensive Care and Pain Control, Medical University of Vienna, Vienna, Austria; ²Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA; ³Medical University of Vienna, Vienna, Austria.
Bleeding complications after lung transplantation (LuTX) are associated with increased morbidity. Risk factors for postoperative bleeding complications after LuTX have not yet been reported. In…
2018 American Transplant Congress
Characterization of Exosomal DNA from Human Lung Transplant Recipients
S. Bansal, M. Sharma, R. Walia, R. Bremner, M. Smith, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hosp & Med Ctr, Phoenix.
Exosomes are small vesicles which contains biological molecules including proteins, RNA`s and miRNAs. It has been reported that exosomes may contain ds DNA originated from…
2018 American Transplant Congress
Pattern of Respiratory Virus Infection (RVI) and Chronic Lung Allograft Dysfunction (CLAD) in Lung Transplant Recipients (LTR)
L. Somerville, S. Drews, K. Halloran, N. Lee, D. Kabbani, H. Hirji, K. Doucette, C. Cervera.
University of ALberta, Edmonton, AB, Canada.
Background: The indirect effects of RVI in LTR are controversial. We aimed to define patterns of RVI in LTR and the impact on CLAD and…
2018 American Transplant Congress
Simultaneous Persistence and Development of Donor and Recipient Tissue Resident Memory T Cells in Lung Transplantation
M. Snyder,¹ T. Connors,² C. Marboe,³ L. Benvenuto,¹ L. Shah,¹ H. Robbins,¹ J. Hook,¹ F. D'Ovidio,⁴ M. Bacchetta,⁴ J. Sonnett,⁴ S. Arcasoy,¹ D. Farber.^4,5
¹Medicine, Columbia University Medical Center, New York, NY; ²Pediatrics, Columbia University Medical Center, New York, NY; ³Pathology, Columbia University Medical Center, New York, NY; ⁴Surgery, Columbia University Medical Center, New York, NY; ⁵Microbiology & Immunology, Columbia University Medical Center, New York, NY.
Introduction: The predominant T cell population in the lung comprises non-circulating tissue-resident memory T cells (TRM); however, the fate of these cells in transplanted lung…
2018 American Transplant Congress
Superiority of Early Everolimus-Based Quadruple Immunosuppression versus Standard Triple Therapy after Lung Transplantation: 12 Months Results from Prospective 4EVERLUNG Study in Germany
J. Gottlieb, C. Neurohr, J. Müller-Quernheim, H. Wirtz, B. Sill, H. Wilkens, V. Besa, C. Knosalla, M. Junge, C. Capusan, M. Strüber.
Klinik, Hannover, Germany; Klinik, München, Germany; Klinik, Freiburg, Germany; Klinik, Leipzig, Germany; Klinik, Hamburg, Germany; Klinik, Homburg, Germany; Klinik, Essen, Germany; Klinik, Berlin, Germany; Novartis Pharma, Nürnberg, Germany; Novartis Pharma, Nürnberg, Germany; Klinik, Hannover, Germany.
The 4Everlung trial was designed to evaluate the benefit of early everolimus (EVR)-based quadruple low immunosuppressive (IS) regimen on kidney function (RF) after LTx.4EVERLUNG is…
2018 American Transplant Congress
Identification of Exosomal Proteins from Human Lung Transplant Recipients
S. Bansal,¹ P. Pirrotte,² M. Saltzman,² K. Garcia,² M. Sharma,¹ M. Gunasekaran,¹ M. Smith,¹ R. Bremner,¹ T. Mohanakumar.¹
¹Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix; ²Collaborative Center for Translational Mass Spectrophotometry Translational Genomics Research Institute, Phoenix.
Molecular mechanisms involved in rejection following human lung transplantation are not well understood. Goal of this study is to identify proteomic signatures in the circulating…
2018 American Transplant Congress
Ultrastructural Changes in Lung Allografts: Endothelial Changes Correlate with Donor Specific Antibody & Antibody Mediated Rejection
M. Alexander, A. Bentall, P. Abell Aleff, J. Scott, A. Roden.
Mayo Clinic, Rochester, MN.
Introduction: Antibody mediated rejection (AMR) causes lung allograft (LA) injury. Challenges with C4d interpretation & lack of specific histological criteria account for difficulty in diagnosing…
2018 American Transplant Congress
Nontuberculous Mycobacteria in Lung Transplant Recipients: Prevalence, Risk Factors and Impact on Survival and Graft Function
D. Friedman, C. Cervera, K. Halloran, G. Tyrrell, K. Doucette.
University of Alberta, Edmonton, Canada.
BACKGROUND. Nontuberculous mycobacteria (NTM) may colonize or infect lung transplant patients. Due to differences in populations studied and geographical diversity of NTM, risk factors for…